Vol. 9 No. 12 (2025): Tropical Journal of Natural Product Research (TJNPR)

Articles

• 

  Pharmacokinetic and Pharmacodynamics Interactions between Andrographis paniculata, Andrographolide, and Oral Antidiabetic Drugs: A Systematic Review of Preclinical Evidence

  Raimundus Chaliks, Sukardiman, Chrismawan Ardianto

  5900 – 5909

  • pdf
  • epub
• 

  Network Pharmacology, Molecular Docking, and Machine Learning Prediction Reveal Andrographolide as a Mitochondrial Modulator in Cardiac Remodeling via TP53

  Muhamad Rizqy Fadhillah, Wawaimuli Arozal, Raymond Rubianto Tjandrawinata, Dewi Sukmawati, Aryo Tedjo, Deni Noviana, Abdul Mun’im, Muhammad Habiburrahman, Edwina Rugayah Monayo, Suci Widya Primadhani

  5910 – 5920

  • pdf
  • epub
• 

  Potential of Curcuma zedoaria Hydrosol as an Antioxidant and Active Ingredient for Emulgel

  Aptika Oktaviana Trisna Dewi, Yunita Dian Permata Sari, Rafiah Inas Zahra, Umi Nafisah

  5921 – 5925

  • pdf
  • epub
• 

  Insecticidal and Larvicidal Activities of the Acetone Extract, Fractions, and Volatile Compounds of Dennettia tripetala (G. Baker) Seeds, and Anticholinesterase Activity of the Identified Compounds

  Samuel E. Ugheighele, Kate E. Imafidon, Abigail A. Imasuen, Ahmed Shakil, Uzma Naqeeb, Taidi Ekrakene

  5926 – 5934

  • pdf
  • epub
• 

  Development of 2D-QSAR Models and Molecular Docking of Protein Tyrosine Phosphatase 1B Inhibitors

  Ismail Lamrani, Fathallaah Bazi, Mounir Ghamali, Fatiha Amegrissi, Bahija Mounir

  5935 – 5944

  • pdf
  • epub
• 

  Molecular Docking Study of Moringin against Inflammatory and Oxidative Stress-Related Targets: Insights into Its Immunomodulatory Potential

  Rafiastiana Capritasari, Arif B. Setianto, Akrom Akrom, Sapto Yuliani, Ichwan R. Rais

  5945 – 5954

  • pdf
  • epub
• 

  Computational Insights into Ludwigia L. Phytochemicals as Potential PDE4B Inhibitors: Molecular Docking and Dynamics Simulations

  Hoang V. Hung, Nguyen Hoan, Vu H. Son, Vu T. T. Le, Ngu T. T. Giang, Cao H. Le

  5955 – 5963

  • pdf
  • epub
• 

  Structure-Based Identification and Dynamic Profiling of Mitragyna speciosa Metabolites Targeting HPV E6 and EBNA1 in Cervical Cancer

  Nabila H. Akbar, Putri H. J. Buih, M. Khoirunnisa, S. Farendina, Aditya M. P. Putra, Muhammad F. Hakiki, Muhammad A. Q. Salim, Taufik M. Fakih

  5964 – 5972

  • pdf
  • epub
• 

  Comparison of the Therapeutic Effects of 2% Areca catechu Gel and 0.1% Triamcinolone Acetonide in Patients with Recurrent Aphthous Stomatitis: A Randomized Clinical Trial

  Liza M. Sari, Sri Rezeki, Munifah Abdat

  5973 – 5978

  • pdf
  • epub
• 

  A Zinc Oxide Microparticle (ZnOMP) Characterization Test Using Sumbawa Oil (Minyak sumbawa) Base Material

  Chiquita Prahasanti, Syafrizal A. Pamungkas, Ika Febryana, Eka F. Augustina, Irma J. Savitri, Veronika P. Widiasih, Izzul Islam

  5979 – 5982

  • pdf
  • epub
• 

  Bioactive Compound Composition and Antioxidant Activity of Aleurone Layers and Whole Grains from Algerian Cultivars of Soft Wheat (Triticum aestivum), Durum Wheat (Triticum durum), and Barley (Hordeum vulgare)

  Schahrazed Cherrak, Mohamed Zairi, Lahouaria Labga, Kheira Rebbah, Samira Meziani, Samia Benayeche, Abassia Demmouche, Norreddine Menadi

  5983 – 5991

  • pdf
  • epub
• 

  Xanthine Oxidase Inhibition and Metabolite Profiling of Aquilaria malaccensis Lam Leaves Extract and Fraction Using FTIR-LCMS

  Aris Suhardiman, Muhaimin, Anis Y. Choerunisa, Yani Mulyani

  5992 – 6002

  • pdf
  • epub
• 

  Phytochemical and Antioxidant Profile of the Ethanol Extracts of Phyllanthus niruri and Bergenia ligulata

  Lida Majidinia, Aya Yaseen Mahmood Alabdali, Jithendra Panneerselvam, Venkatalakshmi Ranganathan, Sasikala Chinnappan, Ravishankar Ram Mani

  6003 – 6007

  • pdf
  • epub
• 

  Topical Effectiveness of Bitter Melon (Momordica charantia L.) Leaf Extract on Healing of Cut Wounds in Female Wistar Rats

  Nurti, Elly Wahyudin, Mardiana Ahmad, Prihantono, Stang

  6008 – 6013

  • pdf
  • epub
• 

  Green Synthesis of Selenium Nanoparticles Using Arthrospira platensis Biomass and Their Anti-Hyperglycemic Effect: An In Vivo Research in Mice

  Serli Viviani Patrisia, Wildan Hidayatullah, Aisyiah Apriliano, Fikri Maya Silvia, Ahmad Shobrun Jamıl, Arinta Agnie Dewantari, Soni Andrıawan

  6014 – 6025

  • pdf
  • epub
• 

  Bidirectional Conversion Models to Harmonize Total Phenolic and Flavonoid Content Analysis in Medicinal Plant Extracts

  Bambang Cahyono, Iin Anjani, Nur A. Oktaviana, Agustina L. N. Aminin, Parsaoran Siahaan, Widayat, Meiny Suzery

  6026 – 6032

  • pdf
  • epub
• 

  Synergistic Antiproliferative Effects of Garcinia cowa Ethyl-Acetate Fraction Combined with Paclitaxel in T47D Breast Cancer Cells

  Mainal Furqan, Fatma S. Wahyuni, Meri Susanti, Dira Hefni, Dachriyanus Hamidi

  6033 – 6040

  • pdf
  • epub
• 

  Therapeutic Efficacy of β-Hydroxybutyrate Supplementation on Weight Loss and Glycemic Control in Fasted Obese and Diabetic Mice

  Rachel N. Balapadang, Rachel N. Balapadang, Iqbal Zulqifli, Dandy S. Damara, Oca N. Fadilah, Hadi Sudarjat

  6041 – 6045

  • pdf
  • epub
• 

  Anticancer Activity of Ethanol Extract of Kleinhovia hospita L. Leaves Against HCT-116 Colorectal Cancer Cells

  Alimuddin Tofrizal, Elzam N. Zulfikri, Bramadi Arya, Rita Maliza

  6046 – 6055

  • pdf
  • epub
• 

  In Silico Study of Bioactive Compounds from Red Fruit (Pandanus conoideus Lamk.) as Inhibitors of Human Alcohol Dehydrogenase

  Dedy N. Hidayat, Gita V. Soraya, Rosdiana Natzir, Syahrijuita Kadir, Andrian Sucahyo, Herlina Yulidia, Marhaen Hardjo

  6056 – 6064

  • pdf
  • epub
• 

  Association of Heme Oxygenase-1 Promoter Polymorphisms and Plasma Heme Oxygenase-1 Levels with Atrial Septal Defect–Associated Pulmonary Arterial Hypertension

  Dewi Karita, Ahmad H. Sadewa, Dyah W. Anggrahini, Anggoro B. Hartopo, Lucia K. Dinarti

  6065 – 6070

  • pdf
  • epub
• 

  Antihypertensive Activity Prediction of Physalis angulata L. Through Computational Analysis

  Marisca E. Gondokesumo, Muhammad R. Rasyak, Mansur Ibrahim

  6071 – 6080

  • pdf
  • epub
• 

  The Effect of Dried Powdered Amnion on the Expression of M1 and M2 Macrophages and Changes in Acute Experimental Wound Area in Rats

  Ferdinand Ferdinand, Afriwardi Afriwardi, David Sontani Perdanakusuma, Hirowati Ali

  6081 – 6085

  • pdf
  • epub
• 

  Comparative Chemotype Characterization and Antibacterial Activity of Essential Oils Obtained from the Leaves of Three Litsea species from Vietnam

  Tran D. Dung, Nguyen Q. Binh, Nguyen H. Thuong, Nguyen N. Tuan, Tran D. Thang

  6086 – 6091

  • pdf
  • epub
• 

  Selective Cytotoxicity and G2/M Cell Cycle Arrest Induced by Taxus sumatrana (Miq.) de Laub. Leaf Extract in HeLa Cervical Cancer Cells: A Comparative Study with Paclitaxel

  Desi E. Putri, Dachriyanus Hamidi, Yozarwardi U. Putra, Almahdy Almahdy, Najihah M. Hashim, Fatma S. Wahyuni

  6092 – 6098

  • pdf
  • epub
• 

  Wound Healing Potential of Hydrogel Extract of Saccharum spontaneum Leaves Using Incision Wound Healing Model in Rats

  Eko S. Wahyuningsih, Asman Sadino, Farhamzah Farhamzah, Neni S. Gunarti, Putri Agustina, Sudrajat Sugiharta, Yogi R. Nugraha, Andi N. Amal, Maulana Y. Alkandahri, Siska R. Dewi, Siti S. Dhaniaty, Tati Kholisoh, Balebat A. Sinangling, Audia N. Z. Adam

  6099 – 6109

  • pdf
  • epub
• 

  Antimicrobial Activity and Time-kill Kinetics of Moringa oleifera Lam. Leaf Extracts Against Human Pathogenic Bacteria

  Asiska P. Dewi, Kony Putriani, Vonny K. Utama, Darmadi Madi, Siti Juariah

  6110 – 6118

  • pdf
  • epub
• 

  In-Silico Screening of Seahorse-Derived Compounds Targeting Kisspeptin, GnRH, FSH, and LH Receptors for Reproductive Health Applications

  Trisnawati Mundijo, Yurnadi H. Midoen, Putra Santoso, Aldi T. Rahman

  6119 – 6127

  • pdf
  • epub
• 

  Traditional Wisdom on Cultivated Edible Plants: Ethnobotany of the Kui Ethnic Group in Sangkha District, Surin Province, Northeastern Thailand

  Piyaporn Saensouk, Surapon Saensouk, Phiphat Sonthongphithak, Auemporn Junsongduang, Khamfa Chanthavongsa, Tammanoon Jitpromma

  6128 – 6143

  • pdf
  • epub
• 

  Physicochemical and Microbial Changes in Fish Cake during Storage Obtained by Sterilization and Oxygen Absorbers

  Agusriansyah Saputra, Agus Supriadi, Herpandi Herpandi, Siti Nurhasanah, Daniel Saputra

  6144 – 6150

  • pdf
  • epub
• 

  Evaluation of the Protective Efficiency of Ethyl Gallate Against Non-Alcoholic Fatty Liver Disease Induced by a High-Fat Diet in Mice

  Yara Annouf, Eswar K. Kilari

  6151 – 6157

  • pdf
  • epub
• 

  Cytotoxic Activity Against Breast Cancer of Ethyl Acetate Fraction of the Fruiting Bodies Ganoderma multiplicatum through Inducing Apoptosis

  Hieu N.P. Nguyen, Quoc T. Tran, Trang T.T. Nguyen

  6158 – 6165

  • pdf
  • epub
• 

  Antioxidant Activity and Phytochemical Composition of Thai Traditional Cannabis Longevity Recipes: In Vitro Evaluation of the Phontecho Remedy

  Chawalit Yongram, Panupan Sripan, Suwadee Chokchaisiri, Orawan Wonganan, Rumrada Meeboonya, Thavatchai Kamoltham, Sasipen Krutchangthong, Panyada Panyatip

  6166 – 6174

  • pdf
  • epub
• 

  Response Surface Methodology-Driven Optimization of HPLC for the Determination of Caffeine, Chlorogenic Acid, and Caffeic Acid in Coffee

  Muhammad Z. M. Saputra, Hari Susanti, Nina Salamah

  6175 – 6183

  • pdf
  • epub
• 

  Ethanol Extract of Cosmos caudatus Attenuates Oxidative Stress and Inflammation in a Testosterone-Induced Benign Prostatic Hyperplasia Rat Model via Reduction of Malondialdehyde, Interleukin-6, and Tumor-Infiltrating Lymphocytes Activity

  Nita Sahara, Ambar Mudigdo, Brian Wasita, Eti P. Pamungkasari, Paramasari Dirgahayu, Risya Cilmiaty

  6184 – 6189

  • pdf
  • epub
• 

  Formulation Development and Quality Evaluation of a Topical Cream Containing a Polyphenol-Rich Extract from Spilanthes acmella Murr.

  Nguyen T. A. Nguyet, Tran T. Thao

  6190 – 6196

  • pdf
  • epub
• 

  Nature’s Remedy: Evaluating the Combined in Vitro and in Vivo Anti-inflammatory Potential of Citrus limon Peel Extracts

  Manel Allem, Malika Meziane Ahmed, Malika Meziane Boukhatem

  6197 – 6202

  • pdf
  • epub
• 

  Phytochemical Composition, Antioxidant, and Acetylcholinesterase Inhibitory Activities of Pluchea pteropoda Extract

  Hung H. Pham, Phong T. Bui, Tra A. Bui, Ngoc D. B. Dao, Tri M. Than

  6203 – 6208

  • pdf
  • epub
• 

  Rice Bran Dextrose Agar as a Cost-Effective Alternative to Standard Fungal Culture Media

  Rafika Rafika, Rahman Rahman, Ridho Pratama, Artati Artati, Mursalim Mursalim, Muhammad Nasir, Widarti Widarti, Nuradi Nuradi, Nurdin Nurdin, Asyhari Asyikin, Nurisyah Nurisyah, Tajuddin Abdullah, Asmawati Asmawati

  6209 – 6213

  • pdf
  • epub
• 

  Computational Insights into the Interaction of Silver Nanoparticles from Mimosa pudica linnaeus with Tumor Necrosis Factor-α and Heat Shock Protein 60: An In-Silico Approach

  Yanti Rahayu, Rauza S.Rita, Ilmiawati Ilmiawati, Nuzulia Irawati, Almurdi Almurdi

  6214 – 6226

  • pdf
  • epub
• 

  The Employment of FTIR Spectroscopy and Multivariate Data Analysis for Authentication Study of Sacha Inchi Seed Oil

  Youstiana D. Rusita, Abdul Rohman, Marlyn D. Laksitorini, Purwanto Purwanto

  6227 – 6234

  • pdf
  • epub
• 

  Structural and Morphological Characterization of Bovine Pericardium–Nigella sativa Composite using XRD and SEM

  Ernie M. Setiawatie, Irma J. Savitri, Ferlina D. A. Y. P. Asano, Aulia G. Syahria, Basril Abbas, Yessy Warastuti, Tantin R. Dwidjartini

  6235 – 6238

  • pdf
  • epub
• 

  Innovative Formulation of Solid Lipid Nanoparticle Loaded with Carrot Seed Essential Oil for Potential Antioxidant Activity and Sun Protection

  Arman Suryani , Azrul R. Affani, Berliana W. Safitri, Indah A. Azis, Muhammad F. E. Aldo, Hagia Sofia

  6239 – 6248

  • pdf
  • epub
• 

  Potential Cytotoxic Isolates of Spigelia anthelmia Linn. against T47D and WiDr Cancer Cells

  Muhammad Taupik, Nanang Fakhruddin, Mohamad A. Mustapa, Endah N. Djuwarno, Qamar U. Ahmed

  6249 – 6257

  • pdf
  • epub
• 

  Effects of Technological Factors on The Properties and Structure of the Mini Oil Stick (Youtiao)

  Tran Cong Danh, Duy H. Truong, Nguyen Thi Mai Huong

  6258 – 6267

  • pdf
  • epub
• 

  Acute and Sub-Chronic Toxicity of the Herbal Remedy Loi-Hoa-Vien-Tot-Bung (LHVTB) in Mice

  Ngai H. T. Tran, Phung P. Hoang, Tai A. Lu, Ngan T. Duong, Huy Q. Dang, Xuong M. Tu, Hoang M. Le

  6268 – 6273

  • pdf
  • epub
• 

  GC-MS Analysis, Determination of Total Flavonoid Content, Sun Protection Factor, and In Vitro Anti-inflammatory Activity of Ethanol Extract of Kokang (Lepisanthes amoena) Leaves

  Fadlilaturrahmah Fadlilaturrahmah, Arnida Arnida, Amalia Khairunnisa, Nani Kartinah, Nashrul Wathan, Lusiana Ernadi Putri, Diana Nurus Sholehah

  6274 – 6280

  • pdf
  • epub
• 

  Phytochemical Profiling and Bioactivity Evaluation of Perilla Species from Thai Nguyen Province, Vietnam

  Tu Q. Trung, Pham V. Khang, Tran T. Hong, Bui D. Nguyen, Shen Sida, Hoang P. Hiep

  6281 - 6287

  • pdf
  • epub
• 

  Ethnobotanical and Ethnopharmacological Study of Medicinal Plants Used for Respiratory Diseases in the Sefrou Region, Morocco

  Nicerine Ourgha, Houda ElYacoubi, Atmane Rochdi

  6288 – 6300

  • pdf
  • epub
• 

  Qualitative and Quantitative Estimation of Glycosides in Stevia rebaudiana Bertoni Callus Cultures under the Influence of Various Growth Regulators

  Lara M. Obaid, Ansam G. Abdulhalem

  6301 – 6306

  • pdf
  • epub
• 

  VEGF and Macrophage Expression in Pulp Inflammation Following Administration of a Combination of Tricalcium Silicate Cement and Galam (Melaleuca cajuputi var. cumingiana) Leaf Extract: In Vivo and In Silico Studies

  Sherli Diana, Irene E. Rieuwpassa, Juni J. Nugroho, Rasmidar Samad, Risfah Yulianty, Nurhayaty Natsir, Nurlindah Hamrun, Muthi’ah N. Putri, Agung S. Wardhana, Maharani L. Apriasari, Tri Nurrahman, Juliyatin P. Utami

  6307 – 6312

  • pdf
  • epub
• 

  Assessment of Essential Oil Yield from Artemisia herba-alba and the Endemic Artemisia mesatlantica in the Middle Atlas of Morocco: A Step Toward Sustainable Valorization

  Achraf Mabrouk, Ayoub Souileh, Hajar Sadrati, Younes El Goumi, Khadija Benhaddou, Mohammed Chrachmy, Reda Benhima, Badr Satrani, Najib Magri, Hayat Oubrahim, Mohamed Ouajdi, Younes Abbas

  6313 – 6318

  • pdf
  • epub
• 

  Induction of JUN and FOS Expression by Gallic Acid Derivatives in MCF-7 Breast Cancer Cells: An in Silico and RT-PCR Study

  Ade Arsianti, Anisah Firda Rachmani, Aryo Tedjo, Norma Nur Azizah, Shun Hirota, Hiroki Tanimoto

  6319 – 6325

  • pdf
  • epub
• 

  The Therapeutic Effect of Bidens Pilosa as Anti-Colon Cancer in Alcohol- Induced Rats: In Vivo and In Silico Method

  Melva Silitonga, Hendro Pranoto, Adriana D. LumbanGaol, Erlintan Sinaga, Feimmy R. P. Sipahutar, Fajar A. Sinaga

  6326 – 6335

  • pdf
  • epub
• 

  A Randomized-Controlled Trial Study of Telecare-Based Interprofessional Collaboration: A New Strategy in Tuberculosis Treatment

  Devi Octavia, Andi Hermansyah, Yunita Nita

  6336 – 6341

  • pdf
  • epub
• 

  Performance of Ipomoea batatas L. Pigment as a pH Strip and Acid–Base Titration Indicator

  Maria A. U. Leba, Adri G. Sooai, Sesilia D.B. Mau, Megawati, Maximus M. Taek, Juvencio D. C. Ruas, Erly G. Boelan, Noemia A. Ruas, Adilson D. C. Ruas, Maria B. Tukan, Faderina Komisia, Raymond F. Mesugama

  6342 – 6351

  • pdf
  • epub
• 

  Ethanol Extract of Hymenocardia acida Tul (Euphorbiaceae) Ameliorates Pentylenetetrazole-Induced Seizures and Neuroinflammation in Mice

  James O. Oni, Chiamaka I. Obi, Gladys O. Adeoluwa, Funmilayo R. Adeniyi, Ibifiri P. Jack, Lily O. Otomewo, Obinna K. Okorie, Olayemi K. Wakeel, Olusegun A. Adeoluwa

  6352 – 6355

  • pdf
  • epub
• 

  Post-germination Application of Trichoderma asperellum for the Biocontrol of Macrophomina phaseolina in Cowpea

  Olusola L. Oyesola, Tonjock R. Kinge, Olufisayo A. Kolade, Olawole O. Obembe

  6356 – 6361

  • pdf
  • epub
• 

  Dietary Zingiber officinale (Ginger) Supplementation Ameliorates Lead Carbonate-Induced Hepato-Renal Toxicity and Inflammation in Female Wistar Rats

  Oluwafemi S. Olaniyi, Kolade P. Folorunso, Foluso O. Ojo, Luqman A. Hassan, Oluseyi Y. Aderibigbe, Olamide S. Olayemi, Tivere S. Okojie, Tolulope A. Edward

  6362 – 6366

  • pdf
  • epub
• 

  Characterization and Temperature-Dependent Adsorption Potential of Hydrothermally Synthesized Manganese Oxide Nanoparticles

  Idris Rabiu, Taofik Uthman, Serdar Surgun, Nasar Mansir

  6367 – 6372

  • pdf
  • epub

• ERRATUM: Antimicrobial Activity of Tripitsajuk Crude Extract against Escherichia coli and Pseudomonas aeruginosa

  Jongkonnee Thanasai, Wanlaya Naowaratwattana, Watchara Kanchanarach, Pacharamon Soncharoen

  6373 - 6381

  • pdf
  • epub

• ERRATUM: Synergistic Inhibition of Chronic Myeloid Leukemia: Combining Imatinib and Naringin to Overcome Drug Resistance

  Kiranmai Gudimetla, Rakesh Barik

  6387 - 6394

  • pdf
  • epub

• ERRATUM: Aqueous Extract Of Ampelopsis Cantoniensis With The Addition Of Curcuma Longa And Taraxacum Officinale: LD50 On Zebrafish (Danio Rerio) Embryos And Nanoformulations For Bacteria Inhibition

  Thi Thanh Mai Nguyen, The Hoai Le, Duc Hai Nguyen, Thi Hong Hanh Nguyen, Thi Thu Huong Le

  6395 - 6402

  • pdf
  • epub

• ERRATUM: Impact of some Bioactive Compounds of Flavonoid-Rich Fraction of Monodora tenuifolia, Benth on Glucose Concentration and Certain Proteins Associated with Glucose Metabolism using Molecular Docking Approach

  Samuel C. Nzekwe, Adetoun E. Morakinyo, Monde Ntwasa, Sogolo L. Lebelo, Oluwafemi O. Oguntibeju, Oluboade O. Oyedapo, Samuel O. Babarinde, Ademola O. Ayeleso

  6403 - 6412

  • pdf
  • epub

• ERRATUM: Formulation and Characterization of Nanostructured Lipid Carriers Composed of Solid Lipids (Cetyl Palmitate and Stearic Acid) and Liquid Lipid (Nyamplung Oil [Calophyllum inophyllum L.])

  M. F. Rochman, Yulias N. Windriyati, Ayu Shabrina, Malinda Prihantini, Danang N. Wibowo, Urva Fresiva, Junvidya Heroweti, Kiki Damayanti, Sheila A. O. Galliano, Nurul Anizha, Defa P. Ardiansa, Arisna Ayuningtyas

  6382 - 6386

  • pdf
  • epub