About the Journal

Tropical Journal of Natural Product Research (TJNPR) is the official scientific publication of the Natural Product Research group, University of Benin; and it is available in both printed and electronic formats. The journal is published monthly.

Tropical Journal of Natural Product Research (TJNPR) is a peer-reviewed, open access online international journal which publishes original research papers. The journal welcomes submission from scholars and experts for possible publication from all over the world. The scope of the journal includes: Pharmaceutical research, chemistry and biochemistry of naturally occurring compounds, biological evaluation of crude extracts, ethnomedicine, traditional and complementary medicine, ethnopharmacology, biomedical research, Biotechnology, Evaluation of natural substances of land and sea and of plants, microbes and animals, pharmacognosy, bioavailability, clinical, pharmacological, toxicological studies and pharmacokinetics of phytochemicals, Isolation and characterization of compounds, structure elucidation, synthesis and experimental biosynthesis of natural Product as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, papers discussing the screening of natural Product for biological activity against different health targets are also encouraged.

Current Issue

Vol. 8 No. 8 (2024): Tropical Journal of Natural Product Research (TJNPR)
Published: 2024-09-01

Articles

  • Dexamethasone Induction of Metabolic Syndrome and Remediation By Medicinal Plants: A Systematic Review

    Shehu-Tijani T. Shittu, Olajumoke J. Ogundele, Seyyid A. Shittu, Grace O. Isehunwa, Ayobami O. Afolabi, Taye J. Lasisi
    7930-7940
    DOI: https://doi.org/10.26538/tjnpr/v8i8.1
    Views | PDF Download | EPUB Download : 304 / 238 / 17

  • The Effects of Mesenchymal Stem Cell on Calpains, Glycogen Synthase Kinase-3β, and Ryanodine Receptor 3 in Animal Models of Alzheimer’s Disease: A Systematic Review

    Nita Afriani, Eryati Darwin, Hirowati Ali, Yuliarni Syafrita
    7941-7946
    DOI: https://doi.org/10.26538/tjnpr/v8i8 2
    Views | PDF Download | EPUB Download : 228 / 126 / 6

  • Assessment of Antifungal Potentials of Ethanol Extract of Cleistocalyx operculatus Roxb Against Cercospora nicotianae for Pesticidal Applicability: In Vitro and In Silico Screening

    Nguyen T. T. Hai, Thanh Q. Bui, Phan T. Quy, Nguyen V. Phu, Nguyen T. T. Thuy, Thi V. A. Nguyen, Nguyen T. Triet, Duy T. Pham, Van D. Tran, Nguyen T. A. Nhung
    7947 - 7955
    DOI: https://doi.org/10.26538/tjnpr/v8i8.3
    Views | PDF Download | EPUB Download : 246 / 153 / 9

  • Olive Cake Prevents Inflammation, Modulates Glomerulopathy, Glomerular Filtration Rate and Improves Renal Functions in Adult Obese Rats Fed a High-Fat Diet Since Weaning

    Mansourou Samba Garba, Sherazede Bouderbala, Omar Kharoubi
    7956 - 7964
    DOI: https://doi.org/10.26538/tjnpr/v8i8.4
    Views | PDF Download | EPUB Download : 126 / 110 / 4

  • Assessment of the Antioxidant Capacity and Cytotoxic Activity of pomoea pes-tigridis

    Manukondu Bhaskar, Kasoju Aruna
    7965-7969
    DOI: https://doi.org/10.26538/tjnpr/v8i8.5
    Views | PDF Download | EPUB Download : 109 / 126 / 4

  • Synthesis and Characterization of Toothpaste Formulated with Nano-hydroxyapatite and Silver Nanoparticles

    Fastabiqul K. Rhamdiyah, Sari E. Cahyaningrum, Rudiana Agustini
    7970-7978
    DOI: https://doi.org/10.26538/tjnpr/v8i8.6
    Views | PDF Download | EPUB Download : 110 / 85 / 4

  • The Antibacterial and Anti-Breast Cancer Activities of Caulerpa racemosa from the Minahasa Peninsula Water and North Sulawesi, Indonesia

    Yessie K. Lengkey, Desy M. H. Mantiri, Suzanne L. Undap, Grace Sanger, Viona W. Lua, Khristin Kondoy, Darus Paransa, Charles Keppel, Wilmar Maarisit, Jabes W. Kanter, Ferdy A. Karauwan, Jeane Mongi
    7979-7983
    DOI: https://doi.org/10.26538/tjnpr/v8i8.7
    Views | PDF Download | EPUB Download : 178 / 115 / 11

  • Unveiling Nature's Treasure: Investigating the Antioxidant and Anticancer Activities of Mas Banana (Musa acuminata colla) Bracts from Lampung, Indonesia

    Riska H. Putri, Brian Wasita, Soetrisno, Heru Priyanto, Eti P. Pamungkasari, Risya Cilmiaty
    7984-7989
    DOI: https://doi.org/10.26538/tjnpr/v8i8.8
    Views | PDF Download | EPUB Download : 109 / 60 / 4

  • Therapeutic Effects of Dipterocarpus alatus Roxb. Ex G. Don Ointment on Methicillinresistant Staphylococcus aureus -Infected Skin Abrasion Wounds in Mice

    Waranya Chatuphonprasert, Kanokwan Jarukamjorn, Nitima Tatiya-aphiradee, Sutthiwan Thammawat, Ploenthip Puthongking, Pathomthat Srisuk
    7990 - 7995
    DOI: https://doi.org/10.26538/tjnpr/v8i8.9
    Views | PDF Download | EPUB Download : 119 / 69 / 6

  • The Effect of Diallyl Trisulfide Administration on The Viability of MDA-MB-231 Cell Lines

    Lysa Veterini, Gondo Mastutik, Nora Ertanti, Mohammad QB Zulfikar, Akbar R Muhammad, Akbar R Muhammad, Rizky F Meirawan, Soetjipto
    7996-8000
    DOI: https://doi.org/10.26538/tjnpr/v8i8.10
    Views | PDF Download | EPUB Download : 104 / 67 / 13

  • Impact of Maturity Stage on Free Radical Scavenging and Antidiabetic Activities of Melinjo (Gnetum gnemon L.) Seed Proteins

    Tri A. Siswoyo, Anang Supriyadi, Ainaya Isnainun, Erni Novianti, Rikno Harmoko
    8001-8006
    DOI: https://doi.org/10.26538/tjnpr/v8i8.11
    Views | PDF Download | EPUB Download : 166 / 87 / 8

  • Differentially Expressed Genes, and Molecular Docking and Dynamic Analysis Revealing the Potential of Compounds in Zingiber officinale Roscoe as Inhibitors of TP53- regulating Kinase (TP53RK) that Influence the p53 Signaling Pathway Related to Apoptosis a

    Surya Dwira, Aryo Tedjo, Muhammad A. Dharmawan, Linda Erlina, Fadilah Fadilah
    8007 - 8013
    DOI: https://doi.org/10.26538/tjnpr/v8i8.12
    Views | PDF Download | EPUB Download : 120 / 54 / 5

  • Microanatomical and Phytochemical Characterization of Amaranthus tricolor L.

    Giau B. N. Lu, Luan C. Tran, Yen T. H. Nguyen, Quan Q. Ly, Ngan P. T. Nguyen
    8015 - 8019
    DOI: https://doi.org/10.26538/tjnpr/v8i8.13
    Views | PDF Download | EPUB Download : 86 / 53 / 3

  • Antifungal Activity of Essential Oils and Aqueous Extracts of Three Moroccan Plants: A Study on Ten Phytopathogenic Fungi

    Laila Reklaoui, Zine El Abidine Bzazou Elouazzani, Hassan Annaz, Manal Kasmi, Abderrazak Rfaki, Hassan Ghazal, Haiat Essalmani, Said Barrijal
    8019 - 8030
    DOI: https://doi.org/10.26538/tjnpr/v8i8.14
    Views | PDF Download | EPUB Download : 120 / 74 / 6

  • Epigallocatechin-3-gallate Modulates NF-κB in Porphyromonas gingivalis - Induced Periodontitis

    Huda R. Qaid, Mohammed A. Aljunaid, Nejva Kaid, Rini D. Ridwan, Hendrik S. Budi, Indeswati Diyatri, Nadhira T. Kamila, Baleegh A. Alkadasi, Shuhdi G. Alaghbari, Ala'a S. Alqhtani
    8031 - 8036
    DOI: https://doi.org/10.26538/tjnpr/v8i8.15
    Views | PDF Download | EPUB Download : 131 / 56 / 1

  • In Vivo Evaluation of Anti-obesity and Anti-inflammatory Effects of Ethanol Leaf Extract of Anredera cordifolia in Rats

    Rusdiana Rusdiana, Sry Suryani Widjaja, Tri Widyawati, Dina Keumala Sari, Rusmalawaty Rusmalawaty
    8037 - 8042
    DOI: https://doi.org/10.26538/tjnpr/v8i8.16
    Views | PDF Download | EPUB Download : 117 / 65 / 6

  • Antioxidant and Sunscreen Activities of Tamarind (Tamarindus indica L.) Rind Ethanol Extract Cream

    Indri Kusuma Dewi, Septiana Laksmi Ramayani, Fatihatul Arsyanah
    8043 - 8046
    DOI: https://doi.org/10.26538/tjnpr/v8i8.17
    Views | PDF Download | EPUB Download : 106 / 67 / 4

  • In Silico Investigations and Potential Approaches of Tectona grandis via Targeting MMP-9 for Triple Negative Breast Cancer

    Sofy Permana, Halida A. Hanum, Maghfira R. Azizah, Silvi Z. Ilmiyah, Aiko Z. Permana, Eviana Norahmawati, Edwin Widodo, Sharida Fakurazi, Yoshiyuki Kawamoto, Agustina T. Endharti
    8047 - 8053
    DOI: https://doi.org/10.26538/tjnpr/v8i8.18
    Views | PDF Download | EPUB Download : 102 / 61 / 1

  • Antioxidant Capacity and Phytochemical Analysis of the Traditional Thai Remedy Benchalokawichian

    Papada Nadee, Achida Jaruchotikamol, Benjamart Cushnie
    8054 - 8060
    DOI: https://doi.org/10.26538/tjnpr/v8i8.19
    Views | PDF Download | EPUB Download : 118 / 62 / 6

  • Inhibitory Effect of the Marine Sponge Amphimidon chloros Extracts Against Multidrug-Resistant Bacteria

    Waed Al-Shamayleh, Haitham Qaralleh, Ola A. Al-Madadheh, Yaseen Al Qaisi, Ahmad AlSarayreh
    8061 – 8067
    DOI: https://doi.org/10.26538/tjnpr/v8i8.20
    Views | PDF Download | EPUB Download : 141 / 44 / 1

  • Antibacterial Activity of Silver Nanoparticles Synthesized Using Vitex grandifolia Against Multidrug-Resistant (MDR) Pathogens

    Kehinde O. Fagbemi, Oluwakemi A Thonda, Olarewaju O. Daramola, Temitope Oyewole, Oladapo O. Adeduro, Amodu Samuel, Daniel Popoola, Daniel A. Aina
    8068 - 8074
    DOI: https://doi.org/10.26538/tjnpr/v8i8.21
    Views | PDF Download | EPUB Download : 88 / 43 / 3

  • Acute and Sub-acute Toxicity Studies of Sweetsop Starch in Female Sprague-Dawley Rats

    Rama Chakradhar Devani, Santosh Kumar Rada
    8075 - 8080
    DOI: https://doi.org/10.26538/tjnpr/v8i8.22
    Views | PDF Download | EPUB Download : 99 / 30 / 3

  • Formulation and Characterisation of pH-Sensitive Eudragit L-100 Nanoparticles for Quercetin Delivery in Lung Carcinoma

    Firas F. Al-Mamoori, Habibah A. Wahab, Waqas Ahmad
    8081 - 8086
    DOI: https://doi.org/10.26538/tjnpr/v8i8.23
    Views | PDF Download | EPUB Download : 112 / 50 / 5

  • UHPLC-HRMS-Based Metabolomics To Evaluate the Antibacterial Compounds of Coix lacryma-jobi Seeds With Different Extraction Solvent Concentrations

    La Ode Sumarlin, Rudi Heryanto, Alfi H. Karomah, Waras Nurcholis
    8087 - 8092
    DOI: https://doi.org/10.26538/tjnpr/v8i8.24
    Views | PDF Download | EPUB Download : 105 / 50 / 3

  • Synthesis and Molecular Docking Studies of New Tetrazole-acetamide Derivatives as Anti-cancer Agent

    Hawraa Q. Manwar, Zainab Al-Shuhaib, Kawkab A. Hussein
    8093 - 8100
    DOI: https://doi.org/10.26538/tjnpr/v8i8.25
    Views | PDF Download | EPUB Download : 88 / 46 / 2

  • In Vitro and In Silico Antioxidant Activity of Lemon-scented Gum (Eucalyptus citriodora Hook.) Cultivated in North Sumatra

    Sovia Lenny, Helmina B. Sembiring, Muhammad Z. E. Sinaga
    8101 - 8105
    DOI: https://doi.org/10.26538/tjnpr/v8i8.26
    Views | PDF Download | EPUB Download : 103 / 75 / 0

  • Rosmarinic Acid Restored Testicular Function and Steroidogenic Hormone Capacity in Wistar Rats Exposed to Perfluorooctanoic Acid Toxicity

    Victoria A. Aluko, Shekins O. Okere, Janet O. Olugbodi, Moses D. Adams
    8106 - 8111
    DOI: https://doi.org/10.26538/tjnpr/v8i8.27
    Views | PDF Download | EPUB Download : 96 / 41 / 5

  • Effect of Dietary Supplementation With Tomato By-Products on Zootechnical Performance and Biochemical Parameters in Broilers (Gallus gallus)

    Samya Boulaajine, Embarek Azerouel, Mohammed Diouri, Hassan Hajjaj
    8112 - 8120
    DOI: https://doi.org/10.26538/tjnpr/v8i8.28
    Views | PDF Download | EPUB Download : 104 / 45 / 16

  • Molecular Identification of Endophytic Fungi from Corn Plant as Antifungal Agent against Fusarium oxysporum

    Rachmawaty Rachmawaty, Uthiya L. Mukrimah, Halifah Pagarra, Muhammad Junda, Andi Munisa, Alimuddin Ali, Oslan Jumadi
    8121 - 8126
    DOI: https://doi.org/10.26538/tjnpr/v8i8.29
    Views | PDF Download | EPUB Download : 153 / 53 / 7

  • Purification of Glycolate Oxidase Enzymes from Peasm (Pisum sativum l.) and Sorghum (Sorghum sudanense J.) Using Ion-Exchange Chromatography and their Physicochemical Characteristics

    Saba Hadi, Zahraa B. Mohammed, Sara H. Oubid, Majid A. AL-Bayati
    8127 - 8130
    DOI: https://doi.org/10.26538/tjnpr/v8i8.30
    Views | PDF Download | EPUB Download : 93 / 67 / 9

  • Effects of Oven-Drying on the Phytochemical and Phenolic Acid Contents of Ethanol Extracts of the Root, Stalk and Leaves of Cymbopogon citratus

    Dilibe C. Urama, Eugene O. Ojua, Uchenna C. Egedigwe, Clara N. Ikegbunam, Anthony E. Nweze, Ebere U. Njoku, Chidera V. Odo, Hyacinth C. Obayi, Marcelus C. Ezema, Angela N. Amujiri
    8131 - 8137
    DOI: https://doi.org/10.26538/tjnpr/v8i8.31
    Views | PDF Download | EPUB Download : 117 / 53 / 5

  • Therapeutic Impact of α-Mangostin and Hyperbaric Oxygen on Alveolar Bone Cell Activity and MMP-8 Expression

    Oryce Zahara, Endah Mardiati, Ani M. Maskoen, Ganesha Wandawa
    8138-8143
    DOI: https://doi.org/10.26538/tjnpr/v8i8.32
    Views | PDF Download | EPUB Download : 84 / 35 / 3

  • Potential Therapeutic Effects of Flavonoid-Rich Extract of Carica Papaya Against Inflammation, Pain, and Pyrexia in Experimental Animals

    Abdirasak Sharif Ali, Yahye Ahmed Nageye, Kizito E. Bello
    8138-8143
    DOI: https://doi.org/10.26538/tjnpr/v8i8.33
    Views | PDF Download | EPUB Download : 89 / 42 / 2

  • Comparism of Bioactive Components in Hydroethanol Extract of Corchorus olitorius and Amaranthus hybridus Leaves

    Omoremime E. Dania, Titilope M. Dokunmu, Emeka E. J. Iweala
    8150-8154
    DOI: https://doi.org/10.26538/tjnpr/v8i8.34
    Views | PDF Download | EPUB Download : 116 / 56 / 5

  • Effects of Aqueous Extract of Crassocephalum rubens (Juss. ex Jacq.) on the Histoarchitecture of the Testis following Cisplatin-Induced Toxicity in Adult Male Wistar Rats

    Babatunde K. Olokodana, Ogor S. Enyi, Chigozie D. Chukwu, Taye O. Bello, Ifunanyachukwu C. Onuchukwu, Aondoakura G. Imo, Victor C. Ajibo, Johnbosco I. Chigbo, Adesola O. Ogunledun, Daniel G. Zamfara, Chibuzor P. Okwor, Edeghonghon C. Okiye, Chibuzo E. Ugwu, Nnabuike A. Okolie, Ikenna K. Uchendu
    8155-8159
    DOI: https://doi.org/10.26538/tjnpr/v8i8.35
    Views | PDF Download | EPUB Download : 203 / 37 / 3

  • Airway Smooth Muscles Relaxant and Mast Cells Stabilizing Activity of Some Medicinal Plants Used in Managing Asthma in North-Western Nigeria

    Ibrahim M. Aliyu, Mohammed G. Magaji, Jamilu Yau, Danjuma N. Muhammed, Zakiyyah Y.Y. Ibrahim
    8160-8167
    DOI: https://doi.org/10.26538/tjnpr/v8i8.36
    Views | PDF Download | EPUB Download : 84 / 29 / 0

  • Evaluation of the In vitro and In silico Pancreatic Lipase Inhibitory Activity of Ethanol Leaf Extract of Tapinanthus cordifolius and its Effect on Oral Glucose Tolerance in Mice

    Amarachi Chike-Ekwughe, Lucy B. John-Africa, Abiodun H. Adebayo, Olubanke O. Ogunlana
    1-8
    DOI: https://doi.org/10.26538/tjnpr/v8i8.37
    Views | PDF Download | EPUB Download : 95 / 62 / 3

  • Plasma-Induced Enhanced Coagulation and Complement Activation of Blood Streams by Platinum Nanoparticles

    Yahye Ahmed Nageye, Abdirasak Sharif Ali, Kizito Eneye Bello
    8170-8175
    DOI: https://doi.org/10.26538/tjnpr/v8i8.38
    Views | PDF Download | EPUB Download : 94 / 39 / 4

  • Morpho-Genetic Relatedness Among Wild and Cultured Clarias gariepinus (Buchell, 1822) Collected from Ogbomoso, South-western Nigeria.

    Ogundiran M. Akinloye, Fawole O. Olubanjo, Olanipekun S. Abimbola, Oduoye T. Olusola, Adebayo E. Adegoke, Majolagbe N. Olusola, Amao J. Ayobami, Balogun H. Adewale, Oladele V. Folashade
    8176-8182
    DOI: https://doi.org/10.26538/tjnpr/v8i8.39
    Views | PDF Download | EPUB Download : 104 / 44 / 3

  • Investigation of the Potential Immunomodulatory Effects of Some Medicinal Plants on the Immune Response of Layer Birds Vaccinated with a Live Salmonella gallinarum Vaccine

    Chizoba A. Asogwa, Paul A. Akpa, Ebele B. Onuigbo
    8189 - 8194
    DOI: https://doi.org/10.26538/tjnpr/v8i8.40
    Views | PDF Download | EPUB Download : 75 / 46 / 3

  • Inhibitory Potential of Pulutan (Urena lobata) Leaf Extract on Inducible Nitric Oxide Synthase as Anti-inflammatory Agent: In Vitro and In Silico Approaches

    Yudi Purnomo, Andri Tilaqza
    8195 – 8201
    DOI: https://doi.org/10.26538/tjnpr/v8i8.41
    Views | PDF Download | EPUB Download : 94 / 48 / 2

  • In vitro Antioxidant, Mineral Analysis and Antimicrobial Activities of Extract and Fractions from the Aerial Part of Heterotis rotundifolia (Sm.) Jacq. Fel

    Godwin N. Enin, Anthony A. Adegoke, Basil N. Ita, Christiana I. Udosen, Victor F. Inyang, Ebuka C. Onuaha, Bassey S. Antia
    8202 - 8211
    DOI: https://doi.org/10.26538/tjnpr/v8i8.42
    Views | PDF Download | EPUB Download : 83 / 38 / 2

  • Isolation and Characterization of Anti-Inflammatory Compounds from Radix bupleuri

    Quoc Hung Dinh, Xuan Phong Pham, Thi Tuyet Nhung Tran, Duy Nhat Lai, Xuan Minh Ha, Thi Thu Hien Tran, Nam Trung Trinh, Van Thu Nguyen, Van Anh Cao
    8212-8216
    DOI: https://doi.org/10.26538/tjnpr/v8i8.43
    Views | PDF Download | EPUB Download : 112 / 56 / 3

  • Antifungal Potential of Selected Plant Extracts on Pathogenic Post-Harvest Fungi Causing Tuber Rot in Ipomoea batatas (L.) Lam. (Sweet Potato)

    Tolulope S. Ewekeye, Esther A. Fashina, Sikiru M. Muhammed, Abdulrazak O. Adebayo, Omobosola B. Fagbohunlu, Oyekunle O. Esan, Oyedamola A. Oke
    8217-8223
    DOI: https://doi.org/10.26538/tjnpr/v8i8.44
    Views | PDF Download | EPUB Download : 145 / 48 / 2

  • Effect of Different Solvent Fractions of Sarcocephalus latifolius (Smith) Bruce on Rat Liver Mitochondrial Membrane Permeability Transition (mPT) Pore

    Joan U. Imah-Harry, Olufunso O. Olorunsogo
    8224-8232
    DOI: https://doi.org/10.26538/tjnpr/v8i8.45
    Views | PDF Download | EPUB Download : 79 / 36 / 8

  • In Vitro Inhibitory Effect of Four Essential Oils against Fluoroquinolone- Resistant Enterobacteriaceae Responsible for Community-Acquired Urinary Tract Infections

    Fatma Mahdi, Mohammed Salih Barka, Mourad Bendahou, Saida Ouslimani, Mohammed Yacine Benziane, Alain Muselli
    8233-8243
    DOI: https://doi.org/10.26538/tjnpr/v8i8.46
    Views | PDF Download | EPUB Download : 107 / 56 / 4

  • Acute (One-Hour) Inhalation toxicological study of Cashew Nut Shell (Anacardium occidentale L.) Fumes in Wistar Rats and Exotic Cockerel Chickens

    Tunmise T. Oladipe, Oladunni O. Falola, Abayomi A. Taiwo, Paul I. Emeje, Elizabeth Dangana, Agenyi Omeje, Favour Maha, Temitope Saliu, Augustina Clement, Nafisat Aliyu, Abayomi Ajayi
    8244-8249
    DOI: https://doi.org/10.26538/tjnpr/v8i8.47
    Views | PDF Download | EPUB Download : 179 / 59 / 5

  • ERRATUM: Enhancing the Pharmaceutical Properties of Ibuprofen through Spherical Agglomeration-Co-Crystallization with Nicotinamide: A Comprehensive Study of Micromeritic, Tabletability, and Dissolution Characteristics

    Indra Indra, Tria G. G. Irawan, Yudila A. Nurwahidah, Firman Gustaman, Fajar Setiawan
    7715 - 7721
    DOI: https://doi.org/10.26538/tjnpr/v8i8.48
    Views | PDF Download | EPUB Download : 100 / 37 / 2

  • ERRATUM: Radiofrequency (4g) Exposure Effects on Dentate Gyrus structure and Function in Wistar rats: Pre- vs. Postnatal Impact

    Fabiyi Oluseyi Sunday, Ogunbiyi Olubunmi Esther, Owolabi Joshua Oladele, Kolawole Oluwaseyi, Olanrewaju John Afees, Olanrewaju Barbra Zainab, Adetunji Opeyemi Adebola, Ogunsanya Sanmi Tunde, Adeniji Kehinde Oluwaseyi, Olanyinka Olugbega Olawole, Oyewumi Samson Oluwole, Onyema Kelechi Roselyna, Ajiboye Oluwapelumi, David Beaulah Mkpuruoma
    7382 - 7387
    DOI: https://doi.org/10.26538/tjnpr/v8i8.49
    Views | PDF Download | EPUB Download : 102 / 40 / 2
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