Potential Therapeutic Effects of Flavonoid-Rich Extract of <i>Carica Papaya<i> Against Inflammation, Pain, and Pyrexia in Experimental Animals
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Abstract
Most diseases has deleterious clinical presentations that are highly discomforting to the patients, often time the treatment and management of these symptoms with known drugs comes with adverse side effects, hence the need for a natural remedy. This study explored the potential therapeutic benefits of a flavonoid-rich extract from Carica papaya (FRECP) on experimental models to study the ant-inflammation, anti-fever and pain relief efficacy. The anti-inflammatory effect was studied using the carrageenan-induced paw oedemamodel. Acetic acid-induced writhing and tail immersion models were utilised for the test for analgesia, whereas Brewer’s yeast-induced and dinitrophenol models were used for the antipyretic study. Each of the 5 investigations involved the random allocation of thirty (30) albino rats into 5 groups, each consisting of 6 animals. Groups 1 and 5 were given distilled water and the conventional medication, whereas groups 2 to 4 received 100, 200, and 400 mg/kg of oral FRECP in each research. The study's results indicated that the observed advantages, especially at the dosage of 400 mg/kg, indicate that the flavonoid content of FRECP hinders crucial enzymes that play a role in inflammation and the production of prostaglandins and decrease discomfort, and pyrexia in a manner that depended on both the dosage and time of administration (p<0.05). We determined that the flavonoid-rich extract of Carica papaya has pharmacological effects on inflammation, pain, and fever.
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