Involvement of Anti-Inflammatory Mechanism in the Antidepressant Activity of Methanol Stem Bark Extract of Adansonia digitata L. (Malvaceae
doi.org/10.26538/tjnpr/v3i2.6
Keywords:
Depression,, Adansonia digitata,, Bacillus Calmette-Guerin,, Inflammatory mechanismAbstract
The plant Adansonia digitata has been reported to possess antidepressant activity mediated via monoaminergic, neuroendocrine and neurotrophic pathways. This study investigated the involvement of anti-inflammatory mechanism in the antidepressant activity of methanol stem bark extract of A. digitata. Acute oral median lethal dose (LD50) was estimated using Organization for Economic Co-operation and Development (OECD 425) method. Depression was induced using Bacillus Calmette-Guerin (BCG, 0.2 mg/kg, i.p.) in mice and readings taken at 0, 4, 24 and 48 hours post BCG administration. Subsequently the antidepressant activity of the extract (250-1000 mg/kg) was assessed using tail suspension test (TST) and open field test (OFT). The extract significantly (p ˂ 0.05) decreased the rectal temperature of mice following BCG-induced sickness 4 and 48 hours post induction. The extract also significantly (p ˂ 0.05) decreased the duration of immobility in the TST at 4 and 48 hours post BCG administration. The extract significantly (p ˂ 0.05) increased the total number of line crossedby mice at 4, 24 and 48 hours post BCG administration. The ability of the extract to ameliorate BCG-induced depression suggests the possible involvement of anti-inflammatory mechanismin its antidepressant activity.
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