Refined Camphor (Kafura Pelebe) Modulates Thoracic Aortae Vasomotor Tone of Rats
doi.org/10.26538/tjnpr/v5i6.24
Keywords:
Cardiovascular, Vaso-relaxation, Camphor, kafura, Adrenergic, CholinergicAbstract
Aqueous extract of refined camphor (AERC) is used in traditional medicine to manage various ailments including erectile dysfunction and to improve blood circulation. These uses are suggestive of possible involvement of refined camphor in vasomodulation. This study evaluated the vasomodulatory potential of AERC. Rings of rats’ thoracic aortae were used to determine the vasomodulatory potential of AERC using isolated organ bath preparations coupled with PowerLab data acquisition system. The direct effect of AERC as well as its influence on noradrenaline-, atropine- and potassium chloride (KCl)-induced responses on the thoracic aortae of rats were investigated. The extract (390 µg/mL) significantly relaxed rat aortic rings, an effect that was significantly (p<0.0001) inhibited by atropine (0.33-3.30 µg/mL). It significantly (p<0.0001) inhibited noradrenaline (3.32 x 10-5 – 9.44 x 100 µg/mL) induced vasoconstriction and significantly relaxed noradrenaline pre-contracted tissues. The extract also significantly (p <0.0001) inhibited potassium chloride (KCl)-induced contraction. The results show that AERC is vasoactive and modulates vascular motor tone via vasodilatory mechanisms involving various pathways including adrenergic and cholinergic mechanisms.
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