Gastro-Floating Drug Delivery Systems - A Review

Ovenseri C. Airemwen; Michael U. Uhumwangho

Authors

Ovenseri C. Airemwen Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, University of Benin, Nigeria
Michael U. Uhumwangho Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, University of Benin, Nigeria

Keywords:

Floating lag time,, Gastric retention,, Sintering, Effervescent,, Non-Effervescent.

Abstract

Sustained release and site targeted drug delivery system have been an interesting research topic in pharmaceutical sector to maximize therapeutic benefits and patient adherence to therapy. GastroFloating Drug Delivery System (GFDDS) is one of the numerous mechanisms to prolong gastric residence time, thereby achieving site-targeted drug release in the stomach for local or systemic effects. This method is useful for medications with narrow absorption window in the upper part of gastro intestinal tract (GIT). Several approaches to GFFDS, including effervescent and noneffervescent methods including the sublimation and sintering techniques used in the formulation of GFDDS with no floating lag time have been discussed in this review. This update also gives an overview of advantages, disadvantages and commercial products of GFDDS.

References

Yie WC. “Novel Drug Delivery System”, Marcel Dekker Inc., New York. 1992; 2:1-3p.

Orakwe C, Airemwen CO, Uhumwangho MU. Formulation And Evaluation of Gastroretentive Floating Matrix Tablets of Metronidazole Using Khaya Ivorensis Gum. Asian J of Pharm Tech and Inn. 2015; 03(12):01-09.

Airemwen CO, Uhumwangho MU. Formulation and Evaluation of floating matrix tablets of metformin using acrylate methacrylate copolymer and Irvingia gabonesis gum. J Pharm and Allied Sci. 2016:13(1):2331-2343.

Chhetri HP, Panna T. An overview on Gastroretentive Drug Delivery System. Kathmandu Univ J Sci and Tech. 2014; 10(1):90-103.

Huanbutta K, Limmatvapirat S, Sungthongjeen S. Novel Strategy to Fabricate Floating Drug Delivery System Based on Sublimation Technique. AAPS Pharm Sci Tech. 2016; 17:693.

Pawar VK, Kansal S, Garg G, Awasthi R, Singodia D, Kulkarni GT. Gastroretentive dosage forms: a review with special emphasis on floating drug delivery systems. Drug Deliv. 2011; 18(2):97-110.

Hardenia SS, Jain A, Patel R, Kaushal A. Floating drug delivery systems: a review. Asian J Pharm Life Sci. 2011; 1(3):284-93.

Oh TO, Kim JY, Ha JM, Chi SC, Rhee YS, Park CW. Preparation of highly porous gastroretentive metformin tablets

using a sublimation method. Eur J Pharm Biopharm. 2013; 83(3):460-467.

Raakesh P, Ashok B. Formulation development and process optimization of theophylline sustained release matrix tablet. Int J Pharm Sci. 2009; 2:30-42.

Tejaswini SP, Ramdas BR. A Review on sintering method in pharmaceutical sciences. Asian J Pharm Tech. 2014; 4(2):106-109.

Soppimath KS, Kulkarni AR, Aminabhavi TM. Development of hollow microspheres as floating controlled release systems for cardiovascular drugs: preparation and release characteristics. Drug Dev Ind Pharm. 2001; 27:507-514.

Whitehead L, Collett JH, Fell JT. Amoxicillin release from a floating dosage form based on alginates. Int J Pharm. 2000; 210:45-52.

Basit A. Colonic metabolism of ranitidine: implications for its delivery and absorption. Int J Pharm. 2001; 227:157-164.

Hoffman A, Stepensky D, Lavy E, Eyal S, Klausner E, Friedman M. Pharmacokinetic and pharmacodynamic aspects of gastroretentive dosage forms. Int J Pharm. 2004; 277:141-154.

Whitehead L, Fell JT, Collett JH, Sharma HL, Smith AM. Floating dosage forms: an in vivo study demonstrating prolonged gastric retention. J Contr Rel. 1998; 3:55-64.

Oth M, Franze M, Timmermans J, Moes A. The bilayer-floated capsule: a stomach directed drug delivery system for misoprostol. Pharma Res. 1992; 9:298-302.

Cargill R, Cadwell LJ, Engle K, Fix JA, Porter PA, Gardner CR. Controlled gastric emptying: Effects of physical properties on gastric residence times of non-disintegrating geometric shapes in beagle dogs. J Pharm Res. 1998; 5:533-536.

Li S, Lin S, Daggy BP, Mirchandani HL, Chien YW. Effect of HPMC and Carbopol on the release and floating properties of gastric floating drug delivery system using factorial design. Int J Pharm. 2003; 253:13-22.

Patel GM. Floating drug delivery system: An innovative approach to prolong gastric retention. J Pharm Sci Tech. 2005; 6:372-383.

Kellner PE, Mojaverian P, Vlasses PH, Rocci ML. Effects of gender, posture and age on gastric residence time of indigestible solid: Pharmaceutical considerations. J Pharm Res. 1988; 10:639-656.

Timmermans J, Andre JM. Factors controlling the buoyancy and gastric retention capabilities of floating matrix capsules: New data for reconsidering the controversy. J Pharm Sci. 1994; 83:18-24.

Chawla G, Gupta P, Koradia V, Bansal AK. Gastroretention:A Means to address regional variability in intestinal drug absorption. J Pharm Tech. 2003; 27:250‐268

Mojaverian P, Vlasses PH, Kellner PE,Rocci ML. Effects of gender, posture, and ageon gastric residence time of indigestible solid: pharmaceutical considerations. J Pharm Res. 1998; 10:639‐656.

Deshpande AA, Rhodes CT, Shah NH, Malick AW. Controlled-Release Drug Delivery Systems for Prolonged Gastric Residence: An Overview. Drug Dev Ind Pharm. 1996; 22:531-543.

Abrahamsson B, Alpsten M, Hugosson M, Jonsson UE, Sundgren M, Svenheden A, Tölli J. Absorption, Gastrointestinal Transit, and Tablet Erosion of Felodipine Extended Release (ER) Tablets. J Pharm Res. 1993; 10:709-718.

Hocking MP, Brunson ME, Vogel SB. Effect of various prokinetic agents on gastrointestinal motility. J Pharm Sci. 1996; 4:182-191.

Bennett CE, Hardy JG, Wilson CG. The influence of posture on the gastric emptying of antacids. Int J Pharm. 1984; 21:341-354.

Rao BP, Kottan NA, Snehith VH, Ramesh C. Development of gastroretentive drug delivery system of cephalexin by using factorial design. ARS Pharm. 2009; 50:8-16.

Garg S, Sharma S. Gastroretentive Drug Delivery System, Business Briefing: Pharmatech. 2003; 1:160-162.

Neha N. An Updated Review on Floating Drug Delivery System. Int J Appl Pharm. 2011; 3(1):1-7.

Sheth PR, Tossounian J. The Hydrodynamically Balanced System. A Novel Drug Delivery System for Oral Use. Drug Dev Ind Pharm. 1984; 10:313-321.

Kawashima Y, Niwa T, Takeuchi H, Hino T, Itoh Y. Hollow microspheres for use as a floating controlled drug delivery system in the stomach. J Pharm Sci. 1992; 81:135-148

Whitehead L, Fell JT, Collett JH. Development of a gastroretentive dosage form. Eur J Pharm Sci. 1996; 4S:182-193.

Ali J, Arora S, Ahuja A, Babbar AK, Sharma RK, Khar RK, Baboota S. Formulation and development of hydrodynamically balanced system for metformin: In vitro and in vivo evaluation.Eur J Pharm Biopharm. 2007; 67:196-205.

Yellanki SK, Singh J, Syed JA, Bigala R, Goranti S, Nerella KN. Design and Characterization of Amoxicillin Trihydrate Mucoadhesive Microspheres for Prolonged Gastric Retention. Int J Pharm Sci Drug Res. 2010; 2:112-118.

Meka L, Kesavan B, Chinnala KM, Vobalaboina V, Yamsani MR. Preparation of a Matrix Type Multiple-Unit Gastro Retentive Floating Drug Delivery System for Captopril Based on Gas Formation Technique: In Vitro Evaluation. AAPS Pharm Sci Tech. 2008; 9:612-623.

Dave BS, Amin AF, Patel MM. Gastroretentive drug delivery system of Ranitidine Hydrochloride: Formulation and In Vitro Evaluation. AAPS Pharm Sci Tech. 2004; 5:1-14.

Aulton, M. Aulton’s Pharmaceutics: The design and manufacture of medicines, Churchill Livingstone, London. 2007. 397p.

Baumgartner S, Kristl J, Vrecer F, Vodopivec P, Zorko B. Optimization of floating matrix tablets and evaluation of their gastric residence time. Int J Pharm. 2000; 195:125-135.

Rosa M, Zia H, Rhodes T. Dosing and testing in vitro of a bioadhesive and floating drug delivery system for oral application. Int J Pharm. 1994; 105:65-70.

United States Pharmacopoeia/ National Formulary. US Pharmacopoeinal Convention Inc., Rockville, 2004. 2125-2126p