Gastro-protective Properties of Acalypha torta Leaf against HCl/Ethanol-Induced Ulceration
doi.org/10.26538/tjnpr/v4i7.8
Keywords:
Acalypha torta,, Lansoprazole,, , HCl-ethanol ulcer-induction,, Ulcer index,, Histology.Abstract
Acalypha torta is one of the plants used in the treatment of various diseases in traditional medicine. The plant is known to possess antidiarrhoeal, immunomodulatory and antimicrobial activities. Despite the ethnomedicinal uses of this plant, there is a paucity of studies on its gastroprotective activity. However, this study was designed to investigate the gastro-protective properties of Acalypha torta leaf extract. The gastro-protective effect of Acalypha torta leaf methanol extract was evaluated using HCl/ethanol ulcer-induction model. A total of twenty-four (24) animals were randomly grouped into six (6) treatment groups labelled groups 1-6. Groups 1 and 2 received 1% carboxymethyl cellulose (CMC). Group 3 received 30 mg/kg b.w lansoprazole while groups 4-6 received 200, 400 and 600 mg/kg b.w extract, respectively. The present findings revealed that methanol extract of Acalypha torta leaf exerted gastro-protective
activity, as shown by its consistent and significant dose-dependent increase in mean ulcer index (MUI) inhibition. Histological investigation of gastric lesions showed that the plant stimulates the scarring cicatrizing process. The gastro protection observed could be attributed to the phytoconstituents of the plant extract which exerted gastro-protective and anti-ulcerogenic effects, possibly by increasing antioxidant enzymes thereby reducing oxidative stress. The gastro-protective properties of the extract could also be due to the ability of the extract to modulate the activities of H+ /K+ATPase thereby normalizing the pH of the gastric juice. The extract possesses a dose dependent gastro protective activity
References
Proctor MJ and Deans C. Complications of peptic ulcer. Surg. 2014; 32(11):599-607.
Amandeep K, Robin S, Ramica S, Sunil K. Peptic ulcer: A review on aetiology and pathogenesis. Int Res J Pharm. 2012; 3(6):34-38.
Mayes PA and Botham KM. Metabolism of unsaturated fatty acids and eicosanoids. In: Murray RK, Granner DK, Mayes PA, Rodwell VW (Eds.). Harper’s illustrated Biochemistry. (26th ed.); New York: McGraw-Hill Companies Inc; 2003. 192 p.
Njoku UO, Umeh CG, Ogugofor MO. Anti-ulcerogenic activity of methanol fraction of Hibiscus asper leaves in albino rats. Afr J Biomed Res. 2020; 23:267-272.
Karaoglan ES, Albayrak A, Kutulu Z, Bayir Y. Gastroprotective and antioxidant effects of Eremurus spectabilis Bieb. methanol extract and its isolated component isoorientin on indomethacin-induced gastric ulcers in rats. Acta Cir Bras. 2018; 33(7):609-618.
Njoku UO, Uzoagulu CH, Ogugofor MO. Protective effect of Cnidoscolus aconitifoilus leaves against diclofenac- induced gastric mucosal damage. Pak J Pharm Sci. 2020; 33(2):651-657.
Serafino A, Vallebona PS, Andreola F, Zonfrillo M, Mercuri L, Federici M, Rasi G, Garaci E, Pierimarchi P. Stimulatory effect of Eucalyptus essential oil on innate cell mediated immune response. BMC Immunol. 2008; 9:17.
Ezekwesili CN and Nwodo OFC. Evaluation of the pharmacological activity of ethanol leaf extract of Acalypha torta (Muell). The Bioscientist. 2013; 1(1):67-72.
Irobi ON and Banso A. Effect of crude leaf extract of Acalypha torta against some anaerobic bacteria. J Ethnopharmacol. 1994; 43:63-65.
Ezekwesili CN, Ghasi S, Nwodo OFC. Evaluation of the blood pressure lowering activity of leaf extract of Acalypha torta Muell. Afr J Pharm Pharmacol. 2012; 6(37):3235- 3241.
Onocha PA, Oloyede GK, Owoye FF. Phytochemical, cytotoxicty and free radical scavenging activities of Acalypha torta leaf extracts (Euphorbiaceae). Arch Appl Sci Res. 2011; 3(6):413-422.
Harborne JB. Phytochemical methods: A Guide to modern techniques of plant analysis. London: Chapman and Hall Ltd; 1973. 279 p.
Trease GE and Evans WC. Pharmacognosy. (15th Ed.). London: Saunder Publishers; 2002. 42 - 44, 221 -229, 246 – 249, 404 -306, 331-332, 391-393 p.
Soni A and Sosa S. Phytochemical analysis and free radical scavenging potential of herbal and medicinal plant extracts. J Pharmacogn Phytochem. 2013; 2(4):22-24.
LiraMota KS, Pita JCLR, Estevam EC, Medeiros VM, Tavares JF, Agra MF, Diniz MFFM, da Silva MS, Batista LM. Evaluation of the toxicity and anti-ulcerogenic effect of the ethanol extract of Maytenus obtusifolia Mart. leaves. Rev Bras Farmacogn. 2008; 18(3):441-446.
Onwukwe OS, Achukwu PU, Azubike NC, Nwachukwu DC, Onyemelukwe AO, Uchendu IK, Eluke BC. Preliminary studies on the anti-ulcer potential of Vitex doniana crude extracts on experimental rat model of ethanol-induced gastric ulcer. Asian Pac J Trop Dis. 2016; 6(9):736-140.
Kiranmai M, Sri BU, Reddy DS, Kumar CBM, Ibrahim M. Evaluation of total phenolic contents and antiulcerogenic activity of root bark of Azadirachta indica. Glob J Med Res. 2012; 12 (6):23-29.
Drury R, Wallington A, Cameroun SR. In: Carleton’s histological techniques. New York: Oxford University Press; 1967. 1-420 p.
Sumbul S, Ahmad MA, Asif M, Akhtar M. Role of phenolic compounds in peptic ulcer: An overview. J Pharm Bioallied Sci. 2011; 3(3):361-367.
de Jesus NZT, de Souza Falcão H, Gomes IF, de Almeida Leite TJ, de Morais Lima GR, Barbosa-Filho JM, Tavares JF, da Silva MS, de Athayde-Filho PF, Batista LM. Tannins, peptic ulcers and related mechanisms. Int J Mol Sci. 2012; 13(3):3203–3228.
Scanlon VC and Sanders T. Essentials of anatomy and physiology. Philadelphia: F.A. Davis and Company; 2007. 376-377 p.
Ezealisiji KM, Ijeomah SC, Agbo MO. Anti-ulcer activity of African walnut Tetracarpidium conophorum nuts against gastric ulcers in rats. Asian Pac J Trop Dis. 2014; 4(2):998- 1001.
Mohammad KHH, Siddiqui RK, Dixit M, Salman KDIM, Azizur R. Amelioration of gastric ulcer using a hydro- alcholic extract of Triphala in indomethacin-induced Wistar rats. Eur J Integr Med. 2016; 8(4):546-551.
Zhu Y, Li X, Mo H, Zhang L, Zhang L, Zhou S, Ma X, Zheng B. Gastroprotective effects of ascaridole on gastric ulcer. Chin. Herb. Med. 2012; 4(1):58-62.
Amin D. Alimentary system and liver. In: Ritters JM, Lewis LD, Mant TGK, Ferro A (Eds). A Textbook of Clinical Pharmacology and Therapeutics. (5th ed.). London: Hodder Arnold; 2007. 251 p.
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