Hepatoprotective Effect of Ethanol Extract of Chinese Betel Herb (Peperomia pellucida (L.)) On CCl4-Induced Hepatotoxicity in Experimental Animals

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Published: 2025-07-31
DOI: https://doi.org/10.26538/tjnpr/v9i7.21
Keywords:
Protective effect, Peperomia pellucida, Hepatotoxicity

Main Article Content

Fitrya Fitrya
Department of Pharmacy, Faculty of Mathematics and Natural Science, Universitas Sriwijaya, South Sumatera, Indonesia. 

Abstract

Chinese betel herb (Peperomia pellucida) contains secondary metabolites, such as alkaloids, flavonoids, phenolics, tannins, saponins, and terpenoids with pharmacological potential. Therefore, this study aims to evaluate the hepatoprotective effect of ethanol extract of P. pelluica herb (EPP) on liver damage caused by CCl4 toxicity. The test was conducted for twenty-one days on 30 male Wistar rats divided into six groups, namely normal control (Na CMC 0.5%), negative control (CCl4 1 mL/kg BW), positive control (Silymarin 100 mg/kg BW), EPP test treatment group with doses of 100, 200, and 400 mg/kg BW. The protective effect of the extract was evaluated based on liver biochemical parameters, macroscopic analysis, and histopathology. The study showed that the EPP group experienced a significant decrease in SGPT, SGOT, ALP, and Total Bilirubin levels. Macroscopic observations and liver organ indices showed liver criteria that resembled normal. Meanwhile, histopathology analysis showed a linear improvement in liver tissue structure with increasing doses. EPP herb can potentially protect the liver from damage caused by CCl4 hepatotoxicity.

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Vol. 9 No. 7 (2025): Tropical Journal of Natural Product Research (TJNPR)

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Articles
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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

How to Cite

Hepatoprotective Effect of Ethanol Extract of Chinese Betel Herb (Peperomia pellucida (L.)) On CCl4-Induced Hepatotoxicity in Experimental Animals. (2025). Tropical Journal of Natural Product Research , 9(7), 3092 – 3096. https://doi.org/10.26538/tjnpr/v9i7.21

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