Recent Strategies for Enhancing the Solubility and Dissolution of Poorly Water-Soluble Curcumin for Therapeutic Purposes and Beyond

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Published: 2025-07-31
DOI: https://doi.org/10.26538/tjnpr/v9i7.70
Keywords:
Bioavailability, Stability, Dissolution, Solubility, Natural compound, Curcumin

Main Article Content

Phuoc-Quyen Le
Department of Pharmacy, Ajou University, Suwon 16499, Republic of Korea
Minh-Thy Nguyen
Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan 330, Taiwan
Quoc-Viet Le
Research Group in Pharmaceutical and Biomedical Sciences, Faculty of Pharmacy, Ton Duc Thang University, Ho Chi Minh City, Vietnam
Hien Van Nguyen
Faculty of Pharmacy, Van Lang University, Ho Chi Minh City 70000, Vietnam

Abstract

Curcumin, a natural compound with significant therapeutic potential, has been the subject of extensive research due to its anti-inflammatory, antioxidant, and anticancer properties. However, its clinical application has been hindered by poor aqueous solubility and low bioavailability, presenting significant challenges for effective drug delivery. This review provides a comprehensive overview of recent strategies aimed at improving the solubility and dissolution of poorly water-soluble curcumin. Key approaches discussed include conventional solubilization methods, such as particle size reduction, solid dispersions, co-crystals, complexation, and deep eutectic solvents, alongside more advanced delivery systems, including nanoparticles and bioconjugates. Each approach is critically evaluated in terms of its solubilizing mechanism, advantages, limitations, and applicability to large-scale production. The review also addresses challenges and future directions that offer promises for overcoming existing barriers, paving the way for the development of efficient, biocompatible, and sustainable curcumin-based therapeutics.

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Vol. 9 No. 7 (2025): Tropical Journal of Natural Product Research (TJNPR)

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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

How to Cite

Recent Strategies for Enhancing the Solubility and Dissolution of Poorly Water-Soluble Curcumin for Therapeutic Purposes and Beyond. (2025). Tropical Journal of Natural Product Research , 9(7), 3413 – 3429. https://doi.org/10.26538/tjnpr/v9i7.70

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