Modulating Effect of Vincamine on the Oxidative Stress Markers and Lipid Profile in High Fat Diet and Streptozotocin-Induced Type 2 Diabetic Rats.
doi.org/10.26538/tjnpr/v6i4.14
Keywords:
Hypoglycemic, High fat diet, Glibenclamide, Streptozotocin, VincamineAbstract
Diabetes mellitus, a silent killer and life threatening metabolic syndrome of human population, is not only characterized by hyperglycemia but also with altered status of oxidative stress markers and lipid profile. The study evaluated the modulating effect of vincamine on the oxidative stress markers and lipid profile in high-fat diet and streptozotocin-induced type 2 diabetic rats. Type 2 diabetes mellitus was induced by feeding the animals with a high-fat diet (40%) for 4 weeks followed by a single intraperitoneal dose of streptozotocin (35 mg/kg b.w). Diabetic rats were treated for 30 days with vincamine at a dose of 30 mg/kg b.w orally. Glibenclamide (600 μg/kg b.w) was used as a standard reference drug to compare the antidiabetic activity of vincamine. The status of glucose, insulin, oxidative stress markers, and lipid profile were analyzed to validate the antidiabetic effect of vincamine. Vincamine significantly (p< 0.05) reduced the concentrations of blood glucose, glycosylated haemoglobin, total cholesterol, triglyceride, low-density lipoprotein cholesterol, and very-low-density lipoprotein cholesterol and increased the levels of high-density lipoprotein cholesterol and serum insulin. Vincamine administration also decreased thiobarbituric acid reactive substances (TBARS) levels and enhanced the status of catalase, superoxide dismutase, reduced glutathione and glutathione peroxidase. Vincamine has been found to possess antidiabetic, antidyslipidemic, and antioxidant properties and the antidiabetic effect of vincamine was much comparable to that of Glibenclamide, a well knownhypoglycaemic drug. Vincamine thus possesses potential to be used as a natural antidiabetic remedy for the treatment of diabetes mellitus.
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