Isolation of Phytochemical Constituents from Hunteria umbellata K. Schum
doi.org/10.26538/tjnpr/v3i3.6
Keywords:
Hunteria umbellata, Ursolic acid,, Oleanolic acid,, SqualeneAbstract
Hunteria umbellata K. Schum has been reported for the treatment of diabetes in Nigeria. In the present study, the ethanolic extract of dried leaves of Hunteria umbellata K. Schum was investigated for the chemical principles. The isolated pure compounds were characterized by NMR, IR and Mass spectral studies. Ursolic acid (1), oleanolic acid (2) and squalene (3) were the main constituents isolated from the extract.
References
Zhang A, Sun H, Wang X. Mass spectrometry-driven drug discovery for development of herbal medicine. Mass Spectrom Rev. 2018; 37(3):307-320.
Telapolu S, Kalachavedu M, Punnoose AM, Bilikere D. MD-1, a poly herbal formulation indicated in diabetes mellitus ameliorates glucose uptake and inhibits adipogenesis - an in vitro study. BMC Compl Altern Med. 2018; 18(1):113.
Khalili N, Fereydoonzadeh R, Mohtashami R, Mehrzadi S, Heydari M, Huseini HF. Silymarin, Olibanum, and Nettle, A Mixed Herbal Formulation in the Treatment of Type II Diabetes: A Randomized, Double-Blind, Placebo- Controlled, Clinical Trial. J Evid Based Compl Altern Med. 2017; 22(4):603-608.
Lau LH, Lew J, Borschmann K, Thijs V, Ekinci EI. The prevalence of Diabetes and its effects on Stroke Outcomes; a meta-analysis and literature review. J Diabet Investig. 2018. [Epub ahead of print]
Mehmood K and Junaid N. Prevalence of undiagnosed type 2 diabetes mellitus in Pakistan: Results of screen-diabetes disease registry. J Pak Med Assoc, 2018; 68(8):1171-1178.
Chang YL, Sheu WH, Lin SY, Liou WS. Good glycaemic control is associated with a better prognosis in breast cancer patients with type 2 diabetes mellitus. Clin Exp Med. 2018; 18(3):383-390.
Maskarinec G, Fontaine A, Torfadottir JE, Lipscombe LL, Lega IC, Figueroa J, Wild S. The Relation of Type 2 Diabetes and Breast Cancer Incidence in Asian, Hispanic and African American Populations-A Review. Can J Diabet. 2018; 42(1):100-105.
Ajiboye TO, Hussaini AA, Nafiu BY, Ibitoye OB. Aqueous seed extract of Hunteria umbellata (K. Schum.) Hallier f. (Apocynaceae) palliates hyperglycemia, insulin resistance, dyslipidemia, inflammation and oxidative stress in high- fructose diet-induced metabolic syndrome in rats. J Ethnopharmacol. 2017; 198:184-193.
Oboh G, Adebayo AA, Ademosun AO, Abegunde OA Aphrodisiac effect of Hunteria umbellata seed extract: Modulation of nitric oxide level and arginase activity in vivo. Pathophysiol. 2019; 26(1):39-47.
Oboh G, Adebayo AA, Ademosun AO, Boligon AA. In vitro inhibition of phosphodiesterase-5 and arginase activities from rat penile tissue by two Nigerian herbs (Hunteria umbellata and Anogeissus leiocarpus). J Basic Clin Physiol Pharmacol. 2017; 28(4):393-401.
Adeyemi OO, Adeneye AA, Alabi TE. Analgesic activity of the aqueous seed extract of Hunteria umbellata (K. Schum.) Hallier f. in rodents. Indian J. Exp. Biol., 2011; 49(9):698- 703.
Igbe I, Ching FP, Eromon A. Anti-inflammatory activity of aqueous fruit pulp extract of Hunteria umbellata K. Schum in acute and chronic inflammation. Acta Pol Pharm. 2010; 67(1):81-5.
Adeneye AA, Adenekan SO, Adeyemi OO, Agbaje EO. Glucose utilization and anti-oxidative mechanisms of the aqueous Hunteria umbellata seed extract in alloxan-induced diabetic rats. Nig J Physiol Sci. 2014; 29(1):71-9.
Falodun A, Nworgu ZA, Ikponmwonsa MO. Phytochemical components of Hunteria umbellata (K. Schum) and its effect on isolated non-pregnant rat uterus in oestrus. Pak J Pharm Sci. 2006; 19(3):256-8.
Seebacher W, Simic N, Weis R, Saf R, Kunert O. Spectral Assignments and Reference Data: Complete assignments of 1H and 13C-NMR resonances of oleanolic acid, 18a- oleanolic acid, ursolic acid and their 11-oxo derivatives. Magn Reson Chem. 2003; 41:636-638.
Woo KW, Han JY, Choi SU, Kim KH, Lee KR. Triterpenes from Perilla frutescens var. acuta and Their Cytotoxic Activity. Nat Prod Sci. 2014; 20(2):71-75.
Alam K, Harun-or-Rashid, Rahman AA, Baki A, Sadik MG. Chemical constituents of Hemigraphis hirta T. anders (Acanthaceae). Pak J Biol Sci. 2002; 5(11):1264-1266.
Morita Y, Hesse M, Schmid H. [Concerning the alkaloid eripine from Hunteria umbellata]. Helv Chim Acta. 1968; 51(6):1438-443.
Bevan CW, Patel MB, Rees AH. The seed alkaloids of Hunteria umbellata. Tetrahedron 1967; 23(9):3809-21.
Bevan CW, Patel MB, Rees AH. The seed alkaloids of Hunteria umbellata: the x-ray crystal structure of corymine hydrobromide monohydrate. Chem Ind. 1965; 14:603-604.
Park SN, Lim YK, Choi MH, Cho E, Bang IS, Kim JM, Ahn SJ, Kook JK. Antimicrobial Mechanism of Oleanolic and Ursolic Acids on Streptococcus mutans UA159. Curr Microbiol. 2018; 75(1):11-19.
Zhou T, Li Z, Kang OH, Mun SH, Seo YS, Kong R, Shin DW, Liu XQ, Kwon DY. Antimicrobial activity and synergism of ursolic acid 3-O-alpha-L-arabinopyranoside with oxacillin against methicillin-resistant Staphylococcus aureus. Int J Mol Med. 2017; 40(4):1285-1293.
Ebeh Messanga R, Dominique Serge NB, Abouem AZA, Norbert MNI, Esther Del Florence MN, Patrick Herve BD, Maximilienne Ascension N, Alex De Theodore A, Dieudonne Emmanuel P, Christian GB, Koert U. Rauvolfianine, a new antimycobacterial glyceroglycolipid and other constituents from Rauvolfia caffra. Sond (Apocynaceae). Nat Prod Res. 2018; 32(16):1971-1976.
Song YL, Gao L, Tang ZY, Li HL, Sun B, Chu P, Qaed E, Ma XD, Peng JY, Wang SS, Hu M, Tang ZY. Anticancer effect of SZC015 on pancreatic cancer via mitochondria- dependent apoptosis and the constitutive suppression of activated nuclear factor B and STAT3 in vitro and in vivo. Journal of Cellular Physiology, 2019; 234(1):777-788.
Tagousop CN, Tamokou JD, Kengne IC, Ngnokam D, Voutquenne-Nazabadioko L. Antimicrobial activities of saponins from Melanthera elliptica and their synergistic effects with antibiotics against pathogenic phenotypes. Chem Cent J. 2018; 12(97):1-9.
Wang L, Wang J, Cao YY, Li WJ, Wang Y, Xu JL, Xu GL. Molecular evidence for better efficacy of hypocrellin A and oleanolic acid combination in suppression of HCC growth. Eur J Pharmacol. 2019; 842:281-290.
Chu P, Li H, Luo R, Ahsan A, Qaed E, Shopit A, Ma X, Lin Y, Peng J, Zhang J, Wang S, Tang Z. Oleanolic acid derivative SZC014 inhibit cell proliferation and induce apoptosis of human breast cancer cells in a ROS-dependent way. Neoplasma, 2017; 64(5):681-692.
Wang X, Li YL, Wu H, Liu JZ, Hu JX, Liao N, Peng J, Cao PP, Liang X, Hai CX. Antidiabetic effect of oleanolic acid: a promising use of a traditional pharmacological agent. Phytother Res. 2011; 25(7):1031-1040.
Castellano JM, Guinda A, Delgado T, Rada M, Cayuela JA. Biochemical basis of the antidiabetic activity of oleanolic acid and related pentacyclic triterpenes. Diabet. 2013; 62(6):1791-1799.
Gutierrez-Rebolledo GA, Siordia-Reyes AG, Meckes- Fischer M, Jimenez-Arellanes A. Hepatoprotective properties of oleanolic and ursolic acids in antitubercular drug-induced liver damage. Asian Pac J Trop Med, 2016; 9(7):644-51.
Wang W, Chen K, Xia Y, Mo W, Wang F, Dai W, Niu P. The Hepatoprotection by Oleanolic Acid Preconditioning: Focusing on PPARalpha Activation. PPAR Res. 2018; 2018:3180396.
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