Effect of Ficus glumosa Delile Leaves on some Biochemical and Haematological Indices of Rats Fed with Kerosene Contaminated Feed
doi.org/10.26538/tjnpr/v4i12.20
Keywords:
Contaminated-feed, Toxicity, Kerosene, Traditional medicine, Ficus glumosaAbstract
Ficus glumosa is used extensively in traditional medicine to manage and remedy some health conditions. This study investigated the effect of powdered Ficus glumosa leaves on some biochemical and haematological parameters of wistar rats fed with kerosene-contaminated (4 mL/100g) feed. Twenty-five female rats were divided into five groups (n = 5) accordingly. Group A: uncontaminated feed only, B: contaminated feed only, C: contaminated feed + 5g of leaves, D: contaminated feed + 10g of leaves and E: contaminated feed + 30g of leaves. The rats consumed water and feed ad libitum for 28 days. They were anesthetized (after treatment period) using ketamine, blood samples and organs were harvested for some haematological and biochemical analyses. Results showed that the leaves facilitated the feed intake and hence the body weights of the rats almost at par with the positive control. Also, the administration of the leaves to rats fed with kerosene-contaminated feed caused a significant increase in RBC, HGB, ALP, Na+ , K+ , LDLc, VLDLc, triacylglycerol and liver weight when compared to the control groups. The levels of serum albumin, urea, total protein and total cholesterol were observed to decrease (P< 0.05) compared to the control groups. Also, concomitant administration of the leaves did not significantly alter kidney/heart relative weights, globulin, AST, ALT, HDLc, Cl- , creatinine, HCO3- , WBC and PLT level when compared with the controls. We therefore conclude that Ficus glumosa leaves may attenuate kerosene-induced haematotoxicity, hepatotoxicity as well as maintained the body weight in rats.
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