Nephroprotective Potential of Persea americana (Avocado) Ethanol-Water Seed Extract and Glucovance in Streptozotocin-Induced Wistar Rats: doi.org/10.26538/tjnpr/v6i2.12

Igbang J. Okputu; Ogar Ironya; Magdalene Obi-Abang; Godwin E. Egbung

Authors

Igbang J. Okputu Department of Biochemistry university of Calabar, Calabar Nigeria
Ogar Ironya Department of Biochemistry university of Calabar, Calabar Nigeria
Magdalene Obi-Abang Department of Biochemistry Cross River University of Technology, Calabar, Nigeria
Godwin E. Egbung Department of Biochemistry university of Calabar, Calabar Nigeria

Keywords:

Nephroprotective, Diabetes, Electrolytes, Metabolites, Haematology, Body-weight

Abstract

Diabetes mellitus is a disorder characterized by hyperglycemia. It is caused by a combination of lifestyle and genetic factors with negative effects to the kidney. The study investigated the nephroprotective potential of P. americana (avocado) ethanol-water seed extract on electrolytes in serum and kidney homogenates, haematological profile and body weight changes of streptozotocin-induced diabetic Wistar rats. A total of thirty-five rats weighing 170-180 g were used. The rats were divided into five groups. Group1 was the normal control, group 2 was the diabetic control, while groups 3-5 were treated with 500 mg/kg glucovance, 500 mg/kg extract and 250 mg/kg each of glucovance and the extract, respectively. The treatment lasted for 28days. The results showed significant decrease in blood glucose, kidney Cl- , serum and kidney Na+ and K+ concentrations, while serum and kidney total bilirubin and serum urea concentrations at 500 mg/kg seed extract, significantly increase (P < 0.05). At 500 mg/kg seed extract, the body weights of the rats significantly increase relative to the diabetic control at (P < 0.05). Haematological results showed significant increase in white blood cells, platelets, red blood cells, haemoglobin, and atypical immature cell counts at 500 and at 250 mg/kg each of glucovance and P. americana seed extract at (P < 0.05). Conclusively, at 250 mg/kg each of the seed extract and glucovance potentiate erythropoiesis and improved glomerular filtration rate. While, at 500 mg/kg of the seed extract, reduced haemorrhagic complications from streptozotocin toxicity.

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