Nephroprotective Potential of Alpha Lipoic Acid in 5-Fluorouracil-Induced Toxicity of Wistar Rats


  • Jamal-Deen I. Tiiba Department of Pharmacology, Faculty of Pharmaceutical Sciences, Ahmadu Bello University, Nigeria
  • Mohammed G. Magaji Department of Pharmacology, Faculty of Pharmaceutical Sciences, Ahmadu Bello University, Nigeria
  • Nuhu M. Danjuma Department of Pharmacology, Faculty of Pharmaceutical Sciences, Ahmadu Bello University, Nigeria
  • Abdulai B. Sallau Department of Biochemistry, Faculty of Life Sciences, Ahmadu Bello University, Nigeria


Wistar rats, Kidney, 5-Fluorouracil, Alpha Lipoic Acid


5-Fluorouracil is a widely used anticancer drug but its therapeutic potential is limited due to its nephrotoxic and hepatotoxic side effects. This study was therefore designed to study the protective effects of Alpha Lipoic Acid (ALA) in 5-Fluorouracil-induced nephrotic damage in Wistar rats. Intraperitoneal injection of 50 mgkg-1 of 5-FU was associated with significant (p ≤ 0.05) increases in the urea, uric acid, creatinine, and potassium levels. However, intraperitoneal injection of 50 mgkg-1 of 5-FU was associated with significant (p ≤ 0.05) decrease in the sodium and magnesium levels in the toxicity model control when compared with untreated control rats. Pretreatment and posttreatment with ALA attenuated these changes. This is indicative of the nephroprotective potential of ALA in 5-FUinduced kidney injury.


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How to Cite

Tiiba, J.-D. I., Magaji, M. G., Danjuma, N. M., & Sallau, A. B. (2020). Nephroprotective Potential of Alpha Lipoic Acid in 5-Fluorouracil-Induced Toxicity of Wistar Rats: Tropical Journal of Natural Product Research (TJNPR), 4(12), 1139–1142. Retrieved from

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