Hepatocurative Effects of Alpha Lipoic Acid in 5-Fluorouracil-Induced Toxicity Involves Activation of TNF Alpha and NF-κβ Signaling Pathway
doi.org/10.26538/tjnpr/v4i10.17
Abstract
Alpha Lipoic Acid is an antioxidant capable of inhibiting xenobiotic-induced liver toxicity
as reported in adriamycin-induced hepatotoxicity in rats. The present research was
designed to study the hepatocurative effects of Alpha Lipoic acid (ALA) in 5-fluorouracil
(5-FU)-induced hepatotoxicity of Wistar rats. Intraperitoneal injection of 50 mgkg-1 of 5-
FU was associated with significant (p ≤ 0.05) increase in the Phenobarbital-induced
sleeping time, NF-κB, TNF-α, AST, ALP, ALT, triglyceride, cholesterol and LDL levels in
the toxicity control when compared to the untreated control rats. However, intraperitoneal
injection of 50 mgkg-1 of 5-FU was associated with significant (p ≤ 0.05) decrease in
albumin, total protein and HDL levels in the toxicity control when compared to the negative
control rats. Daily oral post-treatment with 400 mgkg-1 ALA after 5-FU injection nonsignificantly (p ˃ 0.05) attenuated increase in the HDL level when compared to the
negative control group. Intraperitoneal injection of 50 mgkg-1 of 5-FU was associated
with remarkable necrosis when compared to the normal liver architecture. Daily oral posttreatment with 400 mgkg-1 ALA after 5-FU injection significantly (p ≤ 0.05) attenuated
these trends. ALA has hepatocurative potential in 5-FU-induced hepatotoxicity of Wistar
rats.
Keywords: Alpha Lipoic Acid, 5-Fluorouracil, Hepatocurative, Nuclear transcription factor kappa baeta, Tumour Necrosis factor alpha, Wistar Rats .
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