Antimicrobial, Antifungal and HRBC Membrane Hemolysis and Membrane Stabilization Properties of Various Extracts of Justicia gendarussa
doi.org/10.26538/tjnpr/v4i10.5
Keywords:
Justicia gendarussa, Phytochemicals, Inflammation, Fungi, BacteriaAbstract
Diseases of microbial origin are of important and utmost public health concern. This heightened concern is due to the increasing use of antimicrobial drugs and increasing resistance to antimicrobial agents. Presently, scientists have shown increased interest in the use of plant products against microbial diseases. Inflammation due to injury or age-related natural inflammation is due to denaturation of proteins. The plant Justicia gendarussa is used as antimicrobial and anti-inflammatory medicine. Consequently, this study evaluated Justicia gendarussa leave extracts as antibacterial, antifungal and anti-inflammatory agents. The study evaluated the growth inhibition of many bacterial and fungal strains as well as the membrane stabilizing effect by various extracts of this plant. The extracts inhibited the growth of Escherichia coli, Micrococcus luteus, Bacillus pumilus, B. cereus, B. lecheniformis, Salmonella typhi, Streptococcus mutans bacterial strains, with the ethanol extract showing the highest inhibition as compared to water extract, whereas the petroleum ether extract inhibited the growth of only Micrococcus luteus, Bacillus pumilus, B. lecheniformis. and J. gendarussa. Petroleum ether, ethanol and water extracts also inhibited the growth of many fungi species, viz, Aspergillus niger, Fusarium, Nigrospora oryza, and Aspergillus flavus. Among the extracts, the ethanol extracts showed the greatest inhibition against the growth of Aspergillus niger and Nigrospora oryza. All the extracts of Justicia gendarussa showed marked membrane stabilizing effect, among which the ethanol extract showed more membrane stabilization followed by water and petroleum ether extracts.
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