Freeze-Dried Multicomponent Inclusion Complexes of Curcumin for Enhancement of Solubility and Anti-Inflammatory Activity
doi.org/10.26538/tjnpr/v4i11.8
Keywords:
Multicomponent inclusion complexes, Polyvinylpyrrolidone, Cyclodextrin, CurcuminAbstract
Curcumin (CUR) is an anti-inflammatory agent which exhibits poor oral bioavailability due to its poor solubility. In the present study, freeze-dried multicomponent inclusion complexes (MICs) of CUR were prepared with cyclodextrins (CDs) such as β-cyclodextrin (βCD) and hydroxypropyl-β-cyclodextrin (HPβCD), using polyvinylpyrrolidone K30 (PVP) and poloxamer 188 (POLO) as the auxiliary substances in order to enhance the solubility and anti-inflammatory activity of CUR. Phase solubility study was performed in the absence and presence of auxiliary substances to evaluate their effect on the stability of complexes and complexation efficiency of
βCD and HPβCD. The binary complexes and MICs were prepared by lyophilization method. The prepared complexes were characterized by DSC, ATR-FTIR, XRD and SEM analysis, and evaluated for drug content, saturation solubility and anti-inflammatory activity. The incorporation of auxiliary substances in complex systems resulted in an increased stability constants and complexation efficiency of CDs. DSC and ATR-FTIR analysis confirmed the strong interaction between CUR and CDs in the presence of PVP and POLO. XRD and SEM analysis revealed greater amorphization in case of MIC containing POLO. The incorporation of POLO in MIC enhanced the drug content, solubility and anti-inflammatory activity of CUR to a greater extent. The overall study indicated that freeze-dried MIC of CUR in the presence of POLO could be a cheap and effective way to enhance the solubility and biological activity of CUR than the binary complexes prepared using βCD and HPβCD.
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