Physicochemical Assessment and Drug Potential of Some Phenylpropanoid and Flavonoid Compounds of Ethyl Acetate Eluate from Umudike Propolis


  • Sylvester N. Ugariogu Chemistry Department Federal University of Technology Owerri, Nigeria
  • Ijeoma A. Duru Chemistry Department Federal University of Technology Owerri, Nigeria
  • Fidelis C. Onwumere Chemistry Department Federal University of Technology Owerri, Nigeria
  • John O. Igoli Chemistry Department Federal University of Agriculture Makurdi, Nigeria


Mnova, LC-MS, Phytochemicals, Drug-like properties, Physicochemical, Propolis


Propolis is a natural product produced from bees which have been acclaimed a medicinal product. In this study, greenish propolis samples collected from a private apiary in Umudike of Abia State, Nigeria were subjected to column chromatography using ethyl cetate as solvent. The eluates that were soluble in ethyl acetate only was subjected to liquid chromatography–mass spectrometry (LC-MS) and the result was analyzed using MestReNova (Mnova) software to identify and match the chemical compositions present in the eluate from some already isolated compounds from Propolis in Africa. The following compounds; 2-methyl-2-butenyl (E)- caffeate, Prenyl caffeate or 3-methyl-2-butenyl caffeate, 3-methyl-3-butenyl-(E)-caffeate, isosativan, calycosin, liquiritigenin, naringenin, eupatolitin, acacetin, quercetin, galangin and medicarpin were identified to be present in the sample and they were matched with their
structure, matching score, percentage purity and retention time. Drug-like properties of the matched compounds were determined using the computed physicochemical properties from the Mnova software. The result showed the presence of some known compounds which have been used in medicinal chemistry and drug synthesis. 

Author Biography

Sylvester N. Ugariogu, Chemistry Department Federal University of Technology Owerri, Nigeria

Africa center of Excellence in future energies and electrochemical system (ACE-FUELS) Federal university of Technology, Owerri, Nigeria


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How to Cite

Ugariogu, S. N., Duru, I. A., Onwumere, F. C., & Igoli, J. O. (2020). Physicochemical Assessment and Drug Potential of Some Phenylpropanoid and Flavonoid Compounds of Ethyl Acetate Eluate from Umudike Propolis: Tropical Journal of Natural Product Research (TJNPR), 4(12), 1208–1214. Retrieved from

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