UPLC-MS Profile and Anti-Proliferative Activity of the Berries of an Aggressive Wild-Growing Weed: Solanum elaeagnifolium Cav. (Solanaceae)
doi.org/10.26538/tjnpr/v4i12.16
Keywords:
Colorectal cancer, Jordan, Obesity, Solanum elaeagnifolium Cav, Solanaceae, UPLC-MSAbstract
Although, Solanum elaeagnifolium Cav. is described as a problematic weed difficult to eradicate, it is used in the traditional medicine of different countries for the treatment of different ailments, such as tooth ache and constipation. Its occurrence in Jordan is widespread. In the present study, the aim was to identify the phytochemical composition of the berries and to screen
for different biological activities. Phytochemically, the hydro-alcoholic extracts of the berries of S. elaeagnifolium were analyzed using Ultra Performance Liquid Chromatography-Mass Spectrometry (UPLC-MS). Pharmacologically, using Sulforhodamine B (SRB) assay, the antiproliferative effect of the extracts against four colorectal cancer cell lines (HT29, HCT116, SW620 and CACO2) was tested. The aqueous extracts of the ripe and unripe berries were further evaluated for their in vitro anti-lipidemic and anti-obesity activities. UPLC-MS analysis resulted in the identification of seven bioactive compounds in both extracts. Three of them,
namely; apigenin, hyperoside and luteolin were identified in these berries for the first time. Also,chlorogenic acid, kaempferol, solasodine and solamargine were identified. The extractshibited anti-proliferative activity but lacked anti-obesity activity in vitro. This is the first report on the phytochemical and pharmacological evaluation of the ripe and unripe berries of S. elaeagnifolium Cav., growing wild in Jordan.
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