Bio-Modulation of Platelet Count Following the Administration of Tender Coconut  Water in New Zealand Male Rabbits:  doi.org/10.26538/tjnpr/v2i8.7

Ese  Onuyoh-Adaitire; Blessing Onuyoh; Eloghosa E. Ogbonmwan; Eshiagiamhe G. Tafamel

Authors

Ese Onuyoh-Adaitire Department of Physiology, School of Basic Medical Sciences, University of Benin, Benin City, Nigeria
Blessing Onuyoh Department of Medical Laboratory Science, School of Basic Medical Sciences, University of Benin, Benin City, Nigeria.
Eloghosa E. Ogbonmwan Department of Physiology, School of Basic Medical Sciences, University of Benin, Benin City, Nigeria.
Eshiagiamhe G. Tafamel Department of Physiology, School of Basic Medical Sciences, University of Benin, Benin City, Nigeria.

Keywords:

Tender Coconut water (TCW),, Rabbits,, Platelets,, haematological parameters.

Abstract

Coconut is a fruit of great health benefits. This study was aimed at investigating the biomodulatory effect that oral ingestion of tender coconut water (TCW) exerts on the body during acute inflammatory processes in New Zealand male rabbits. A longitudinal study was adopted in this study using fifteen rabbits (n = 15) and having 4 treatments comprising them. Treatment 1 served as the basal stage without TCW administration. Treatment 2 includes 2 weeks post coconut water administration. Treatment 3 includes 4 weeks post TCW administration. Treatment 4 includes withdrawal of TCW administration. Oral doses of TCW, 5 mL/kg body weight were administered daily and maintained for six weeks. Blood samples were collected at weeks 2, 4 and 6 for the estimation of haematological parameters including white blood cell counts (WBC) and differentials, erythrocyte sedimentation rate (ESR), platelet counts and C-reactive protein concentration. Monocyte concentration (11.07 ±1.19%) in treatment 2 was significantly (p < 0.05) higher than those of treatment 1, 3 and 4%. Platelet concentration in group 1 was increased significantly (p < 0.05) compared to treatments 2 and 3 following the administration of TCW and increased again upon withdrawal of TCW [treatment 4 (280.27 ± 25.30 x 109/L)]. C-reactive protein was increased significantly in treatment 1 (2.93 ± 0.42) compared to treatments 2, 3 and 4. The data obtained from this study showed that the physiology of platelet during acute inflammatory conditions may be modulated by the administration of TCW.

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