Synthesis, Characterization and Antibacterial Activity of some Hg(II) Complexes with Mixed Benzyl 2-(2-oxoindolin-3-ylidene) Hydrazinecarbodithioate and Phosphines or Amines Ligands
doi.org/10.26538/tjnpr/v5i5.17
Keywords:
Biological activity, Diphosphines, Mercury complexes, Dithiocarbazide, IsatinAbstract
Isatin-derived schiff bases with S-dithiocarbazate ester and their complexes are increasingly important for antibacterial activity, so new Hg complexes were prepared with benzyl 2-(2-oxoindolin-3-ylidene) hydrazinecarbodithioate (BHT) and diphosphines (dppm, dppe, dppp and dppb) or amines (bipy, phen). The phosphine complexes have the given formulas [Hg2(BHT)2µ(dppm)2]Cl4 , [Hg(BHT)(diphosphine)Cl]Cl (diphosphine; dppm, dppe), while the amine complexes have the formulas; [Hg(BHT)(amines)]Cl2. The prepared complexes have been characterized by molar conductivity, elemental analysis, FTIR, 31P-NMR and 1H-NMR. Furthermore, this study concludes the evaluation of biological activity of prepared complexes against three bacterial species Staphylococcus Epidermidis and Staphylococcus aureus (gram positive) and Citrobacer Freundii (gram negative) by Agar well method where the antibiotic Amikacin used as a comparison material, prepared complex [Hg(BHT)(bipy)]Cl2 showed activity against Staphylococcus aureus more than amikacin, while the [Hg2(BHT)2µ(dppe)2]Cl4, [Hg(BHT)(bipy)]Cl2 and [Hg(BHT)(Phen)]Cl2 complexes showed activity against Staphylococcus Epidermidis more than amikacin, the [Hg2(BHT)2µ(dppe)2]Cl4, [Hg(BHT)(dppb)]Cl2, [Hg(BHT)(bipy)]Cl2 and [Hg(BHT)(Phen)]Cl2 complexes showed activity against Citrobacter freundii more than amikacin in the minimum concentration.
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