The Effects of Flauzifop-p-butyl on Behavioural Changes, Acetylcholinesterase, Serum Biochemical Parameters, and Haematological Indices in Albino Rats

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Published: Nov 1, 2024
DOI: https://doi.org/10.26538/tjnpr/v8i10.25%20
Keywords:
Fluazifop-p-butyl, Behaviour, Acetylcholinesterase, Haematology, Biochemical, Albino rats

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Dennis A. Nwachukwu
Department of Zoology and Environmental Biology, University of Nigeria, Nsukka, Nigeria
Ikenna K. Uchendu
Department of Medical Laboratory Science, University of Nigeria Enugu Campus, Enugu State, Nigeria.
Gladys O. Nwafor
Department of Medical Laboratory Science, University of Nigeria Enugu Campus, Enugu State, Nigeria.
Celestine C. Ogbonna
Department of Physiology, University of Nigeria, Enugu campus, Nigeria.
Isaiah A. Kwaor
Joseph Sarwuan Tarka University, PMB 2373, Makurdi, Benue state, Nigeria.
John C. Onyishi
Faculty of Pharmacy, University of Nigeria, Nsukka, Nigeria
Onyemaechi H. Nwokwu
Department of Medical Laboratory Science, Ebonyi State University, Nigeria.
Gabriel C. Jideofor
Department of Medical Laboratory Science, Ebonyi State University, Nigeria.
Onyedikachi M. Okpara
Department of Medicine and Surgery, Niger Delta University Wilberforce Island Amasoma Bayelsa State, Nigeria
Ogadima R. Obinwa
Department of Biological sciences, University name: University of Agriculture Makurdi, Benue state, Nigeria.
Ezekiel O. Simon
Department of Human Anatomy, Federal University of Lafia, Nasarawa State, Nigeria.
Eleanor C. Ewurum
Department of Medical Laboratory Science, Nnamdi Azikiwe University, Awka, Nigeria.
Ifeoma B. Agbowu
Department of Biological sciences, University name: University of Agriculture Makurdi, Benue state, Nigeria.
Aisha O. Ishaq
Department of Biochemistry, University of Maiduguri , Bornu State, Nigeria.
Precious C. Kalu
Department of Human Anatomy, College of medicine, Enugu State University of Science and Technology, Enugu, Nigeria.
Victor C. Ajibo
F. Erismann Institute of Public Health, I.M Sechenov First Moscow State Medical University, Moscow, Russia.
Ifeanyichukwu, P. Ugochukwu
Faculty of Pharmacy, University of Nigeria, Nsukka, Nigeria
Sonia E. Okereke
Department of Medical Laboratory Science, Abia State University, Uturu, Abia State, Nigeria.
Umoizotu O. Ojo
Department: Medical Laboratory Science, Babcock University, Ogun State, Nigeria.

Abstract

Fluazifop-p-butyl (FPB) is an herbicide that inhibits the enzyme acetyl-CoA carboxylase (ACCase), which is active in lipid biosynthesis in plants. This study evaluates the effects of FPB on the behaviour, brain acetylcholinesterase, biochemical parameters, and hematological indices in orally exposed rats. Thirty-two (32) male albino rats (Rattus norvegicus) (80 – 188 g) were randomly grouped into A to D. Group-D served as control, while animals in groups A, B, and C received FPB at 75 mg/kg, 37.5 mg/kg, and 18.75 mg/kg, respectively, for 14 days. FPB caused significant changes in behaviour, acetylcholinesterase, some biochemical parameters, and some hematological indices at p < 0.05. When compared to the control group, the treatment group exhibited a generally torpid state, a lower reactivity to touch, and decreased food consumption. These responses abated during the 7 days of withdrawal. It was found that the white blood cell (WBC) total count decreased in treatment groups compared to control. This decrease was duration- and dose -dependent even after the 7 days of withdrawal. Neutrophil count followed the pattern of WBC total count, while lymphocyte count increased significantly. Urea, creatinine, alanine transaminase, aspartate transaminase, alkaline phosphatase, acid phosphatase, and acetylcholinesterase significantly increased (p < 0.05), while total protein and glucose significantly decreased following the administration of FPB. Hepatosomatic indices were not affected in the FPB-treated groups. Overall, the results suggest that FPB modulates the behaviour, acetylcholinesterase, and haematological and biochemical parameters in rat.

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How to Cite
Nwachukwu, D. A., Uchendu, I. K., Nwafor, G. O., Ogbonna, C. C., Kwaor, I. A., Onyishi, J. C., Nwokwu, O. H., Jideofor, G. C., Okpara, O. M., Obinwa, O. R., Simon, E. O., Ewurum, E. C., Agbowu, I. B., Ishaq, A. O., Kalu, P. C., Ajibo, V. C., Ugochukwu, I. P., Okereke, S. E., & Ojo, U. O. (2024). The Effects of Flauzifop-p-butyl on Behavioural Changes, Acetylcholinesterase, Serum Biochemical Parameters, and Haematological Indices in Albino Rats. Tropical Journal of Natural Product Research (TJNPR), 8(10), 8810-8818. https://doi.org/10.26538/tjnpr/v8i10.25
Issue
Vol. 8 No. 10 (2024): Tropical Journal of Natural Product Research (TJNPR)
Section
Articles
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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

How to Cite

Nwachukwu, D. A., Uchendu, I. K., Nwafor, G. O., Ogbonna, C. C., Kwaor, I. A., Onyishi, J. C., Nwokwu, O. H., Jideofor, G. C., Okpara, O. M., Obinwa, O. R., Simon, E. O., Ewurum, E. C., Agbowu, I. B., Ishaq, A. O., Kalu, P. C., Ajibo, V. C., Ugochukwu, I. P., Okereke, S. E., & Ojo, U. O. (2024). The Effects of Flauzifop-p-butyl on Behavioural Changes, Acetylcholinesterase, Serum Biochemical Parameters, and Haematological Indices in Albino Rats. Tropical Journal of Natural Product Research (TJNPR), 8(10), 8810-8818. https://doi.org/10.26538/tjnpr/v8i10.25

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