The Valuable Medicinal Plants of Northeast India: Illicium griffithii Hook. f., Pothos scandens L. and Sarcostemma acidum (Roxb.) Voigt
doi.org/10.26538/tjnpr/v5i8.1
Keywords:
I. griffithii, P. scandens, S. acidum, Traditional uses, Chemical constituents, BioactivityAbstract
Illicium griffithii Hook. f., Pothos scandens L. and Sarcostemma acidum (Roxb.) Voigt are important medicinal plants available in sub-Himalayan region of Northeast India. The study was designed to investigate the plants for their traditional values responsible for the treatment of several diseases along with diverse chemical constituents and biological activities. A bibliographic survey was conducted by exploring recognized books and searching Scientifific databases (ScienceDirect, SciFinder, Google Scholar, and PubMed) for the available information on the three species. A total of 80 references were covered with 49 compounds reported from these three plants till date. This review demonstrates the potential of the plants I. griffithii, P. scandens and S. acidum as a source of therapeutic agents.
References
Machairiotis N, Vasilakaki S, Kouroutou P. Natural products: Potential lead compounds for the treatment of endometriosis. Eur J Obst Gynecol Reprod. 2019; 245(11):7-12.
Fave YT, Fatima MD, Hafsat AS, Musa AA, Abdulqadir BB. Evaluation of Antidiabetic, Phytochemical and Acute Toxicity of the Methanol Seed Extract of Senna occidentalis Linn. Trop J Nat Prod Res. 2021; 5(6):1101-1105.
El Ouahdani K, El Moussaoui A, Benbacer L, Bousta D.Ethnobotanical Study of Medicinal Plants Used in the
Treatment of Cancers in the City of Casablanca (WestCentral of Morocco). Trop J Nat Prod Res. 2021; 5(6):1044-1054
Yuan S, Gopal JV, Ren S, Chen L, Liu L, Gao Z. Anticancer Fungal Natural Products: Mechanisms of Action and Biosynthesis. Eur J Med Chem. 2020; 202(18):112502.
Elatif RA, Shabana M, Ibrahim LF, Mansour R, Awad HM, Sharaf M. Chemical Composition and Biological Activity
of Salicornia fruticosa L. Egypt J Chem. 2020; 63(5):1713-1721.
Suhitha S, Devi SK, Gunasekaran K, Pakyntein HC, Bhattacharjee A, Velmurugan D. Phytochemical Analyses
and Activity of Herbal Medicinal Plants of North- East India for Anti-Diabetic, Anti-Cancer and Anti-Tuberculosis
and their Docking Studies. Curr Top Med Chem. 2015; 15(1):21-36.
Chatterjee S, Saikia A, Dutta PK, Ghosh D, Pangging G, Goswami AK. Biodiversity Significance of North East India. Technical report, WWF, India. 2006; 71p.
Deori C, Roy DK, Talukdar SR, Pagag K, Sarma N. Diversity of the genus Clerodendrum Linnaeus (Lamiaceae)
in North East India with special reference to Barnadi wildlife sanctuary, Assam. Pleione. 2013; 7(2):473-488.
Barua CC, Patowary P, Bordoloi MJ, Dutta PP, Dutta DJ, Purkayastha A, Barua IC. Attenuating Effect of Elsholtzia
Communis (Collett & Hemsl.) Diels. on Dysregulated HPA Axis in Stressful Conditions. Int J Pharmacog Phytochem
Res. 2016; 8(4):651-658.
Bhattacharyya NK, Sarmah GK, Goswami BN, Borthakur N, Kataky JCS. New Protolimonoids and Limonoids: art
IV - Transformation of Naturally occurring 6a-Acetoxy azadirone to new limonoids. J Ind Chem Soc. 2004; 81(5):433-435.
Sarmah GK, Bhattacharyya NK, Goswami BN, Borua P, Kataky JCS. Derivatives of Paniculatin and their antifungal activities. J Ind Chem Soc. 2003; 80(11):1-6.
Bhattacharyya NK and Kataky JCS. A Facile Microwaveinduced Synthesis of Heterocyclic Compounds and a
Dialdehyde from a Naturally Occurring Limonoids. J Ind Chem Soc. 2009; 86(9):959-962.
Kirtikar KR, Basu BD. Indian Medicinal Plants. (2nd ed.). Delhi: Jayyed Press; 1975; 60p.
Saha D and Sundriyal RC. Stand structure, phenology and fruit yield of Illicium griffithii in western Arunachal
Pradesh, North east India. Ind J Forest. 2010; 33(4):475-488.
Liu YN, Su XH, Huo CH, Zhang XP, Shi QW, Gu YC. Chemical Constituents of Plants from the Genus Illicium. Chem Biod. 2009; 6(7):963-989.
Vijayakumar A, Jeyaraj B, Raj MK, Nimal IVS, Das C, Balachandran C, Agastian P, Ignacimuthu S. In vitro
cytotoxicity, a-glucosidaseinhibition, antioxidant, and free radical scavenging activities of Illicium griffithii fruits. Med Chem Res. 2013; 23(6):2769-2779.
Vijayakumar A, Kumar PP, Jeyraj B. Antioxidant activity of Illicium griffithi Hook. F. & Thoms Seeds - in vitro.
Asian J Pharm Clin Res. 2013; 6(2):269-273
Vijayakumar A, Duraipandiyan V, Jeyaraj B, Agastian P, Raj MK, Ignacimuthu S. Phytochemical analysis and in
vitro antimicrobial activity of Illicium griffithii Hook. f. & Thoms extracts. Asian Pac J Trop Dis. 2012; 2(3):190-199.
Saraswathy A, Shakila R, Lavanya SM, Arunmozhidevi A. Essential oil constituents of Illicium griffithii and its
antimicrobial activity. Pharmacogn Mag. 2010; 6(23):208-211.
Bordoloi M, Borah J, Roy K, Dutta C, Baruah C, Rao PG. Method for the Extraction of Shikimic Acid. Council of
Scientific and Industrial Research, New Delhi, (IN). 2013. United States patent US 2013/0137895 A1.
Sojeetra NH and Acharya R. A review on ethnomedicinal claims and spread of Pothos scandens L. Eur J Med Plants. 2020; 31(5):22-28.
Kanjilal UN, Kanjilal PC, Das A, Purkayastha C. Pothos scandens L. Fl Assam. 1936; 1(2):60-61.
Boyce PC. A review of Pothos L. (Araceae: Pothoideae: Pothoeae) for Thailand. Thai Forest Bull (Bot). 2009;
(1):15-26.
Zade NS. The Occurrence of Specialized Vessels in the Stem of Pothos scandens L, (Araceae). Int J Sci Res. 2015;
(1):1060-1061.
Kim J, Jeong SH, Lee W, Min H. In vitro anti-inflammatory activity of Pothos scandens extract in RAW 264.7 cells.
Food Sci Biotechnol. 2017; 26(3):791-799.
Bhandary MJ, Chandrashekar KR, Kaveriappa KM. Medical ethnobotany of the Siddis of Uttara Kannada
district, Karnataka, India. J Ethnopharmacol. 1995; 47(3):149-158.
Sangwoo L, Chunjie X, Shengji P. Ethnobotanical survey of medicinal plants at periodic markets of honghe prefecture in Yunnan Province, SW China. J Ethnopharmacol. 2008; 117(2):362-377.
Deepa MR, Dharmapal S, Udayan PS. Medicinal plants in the selected sacred groves of Kodungallur, Thrissur district, Kerala. J Med Plants Stud. 2016; 4(3):149-155.
Ayyanar M and Ignacimuthu S. Traditional knowledge of Kani tribals in Kouthalai of Tirunelveli hills, Tamil Nadu, India. J Ethnopharmacol. 2005; 102(2):246-255.
Khare CP. Indian medicinal plant. Springer Science, Berlin; 2007; 515p.
Liu H, Bi JL, Wang YH, Gu W, Su Y, Liu F, Yang S, Hu G, Luo J, Yin G, Long C. Methyl Pothoscandensate, a new
ent-18(4-3)-Abeokaurane from Pothos scandens. Helvetica Chimica Acta. 2012; 95(7):1231-1237.
Dogra KS, Chauhan S, Jalal JS. Assessment of Indian Medicinal plants for the treatment of Asthma. J Med Plants
Res. 2015; 9(32):851-862.
Das AK, Dutta BK, Sharma GD. Medicinal plants used by different tribes of Cachar district, Assam. Ind J Trad
Knowledge. 2008; 7(3):446-454.
Muhit MA, Izumikawa M, Umehara K, Noguchi H. Phenolic constituents of the Bangladeshi medicinal plant
Pothos scandens and their anti-estrogenic, hyaluronidase inhibition, and histamine release inhibitory activities.
Phytochem. 2015; 121(1):30-37.
Muhit MA, Umehara K, Sharmin N, Noguchi H. Cycloartane and stigmastane type triterpenoids from Pothos scandens inhibit estradiol (E2) induced proliferations in breast cancer cells. Dhaka Univ J Pharm Sci. 2019; 18(1):93-102.
Karunathilaka BSB, Priyadarshana YA, Rajapakse S, Jayasinghe L, Wickramasinghe A. Antimicrobial activity
and Brine Shrimp Lethality of Some Selected Medicinal Plants. RSU Int Res Conference, Rangsit University, Thailand. 2016.
Sajeesh T, Aruachalam K, Parimelazhagan T. Antioxidant and antipyretic studies on Pothos scandens L. Asian Pac J Trop Med. 2011; 4(11):889-899.
Vinayaka KS, Kekuda TRP, Rajkumar N, Chandrashekar MB, Banakar S, Hegde SV. Studies on Antibacterial,
Anthelmintic and Larvicidal Efficacy of Pothos scandens L. Res J Pharm Technol. 2009a; 2(4):850-853.
Vinayaka KS, Hegde SV, Banakar S, Kekuda TRP. Antifungal potency of Gnidia glauca (Fresen) Gilg and
Pothos scandens L. J Nat Prod. 2009b; 5(1):146-148.
Yusuf ATM, Rashid MMU, Hassan MM, Sayeed MA, Jainul MA. In-Vitro Cytotoxic and Thrombolytic Potential
of Pothos Scandens L. J Pharm Phytochem. 2013; 2(1):193-198.
Rani L, Mohan VR, Maruthupandian A. Pharmacognostical and phytochemical studies on Pothos scandens L. Int J Phytomed. 2010a; 2(1):277-283.
Lalitharani S, Mohan VR, Regini GS. Ethnomedicinal plants used by Kanikkars in Karaiyar of Agasthiamalai
biosphere, Tamil Nadu. J Econ Taxon Bot. 2010b; 34(2):472-477.
Mohammed HKP, Hanan S, Saraswathi R, Prasad MG, Chandini N. Formulation and evaluation of herbal gel of
Pothos scandens Linn. Asian Pac J Trop Med. 2010; 3(12):988-992.
Mohammad FH, Islam A, Mohammad LB, Moghal MR, Hossain MS. In vitro thrombolytic potential of root extracts of four Medicinal plants available in Bangladesh. Ancient Sci Life. 2014; 33(3):162-164.
Jethinlalkhosh JP, Arun A, Victor AD. Phytochemicals, antioxidant and free radical scavenging of hydroethanolic
extract of aerial parts of Pothos scandens L. Asian J Phar Clin Res. 2016a; 9(3):236-239.
Jethinlalkhosh JP, NAIR SS, Praveena P, Victor ADD. Cytotoxicity and Apoptotic inducibility of hydroethanolic
extract of aerial parts of Pothosscandens L. Int J Pharm Pharm Sci. 2016b; 8(7):274-276.
Jethinlalkhosh JP, Praveena P, Victor ADD. Therapeutic Effect of Hydro-Ethanolic Extract of Pothos scandens L on key Carbohydrate Metabolizing Enzymes and Xenobiotic Marker Enzymes in DMBA Induced Experimental
Mammary Carcinoma. Ind J Pharm Edu Res. 2017a; 51(3):418-426.
Jethinlalkhosh JP, Praveena P, Victor ADD. Preliminary Screening of Hydro-ethanolic Extract of Pothosscandens L for its Potential Anticancer Activity. J Appl Sci Eng Method. 2017b; 3(3):522-528.
Sainuddin T. Formulation & Pharmacological Evaluation of Herbal Gel of Pothos Scandens Linn. Webmed Central Wound Healing. 2010; 1(12):WMC001344.
Hossain MK, Seal B, Siddiki MAK, Mazumder K. Antidiabetic and Bronchodilator Activities of Pothos scandens
Linn Leaves. Int J Pharmacogn Phytochem Res. 2015; 7 (6):1202-1207.
Junaid S, Dileep N, Rakesh KN, Pavithra GM, Vinayaka KS, Kekuda TRP. Anticariogenic activity of Gnidia glauca
(Fresen.) Gilg, Pothos scandens L. and Elaegnus kologa Schlecht. J Appl Pharm Sci. 2013; 3(3):20-23.
Boomibalagan P, Eswaran S, Rathinavel S. Traditional uses of medicinal plants of Asclepiadaceae by Rural people in Madurai district, Tamil Nadu, India. Int J Bot. 2013; 9(3):133-139.
Dave BK, Dhirawat R, Kumawat M. Pharmacognostical study of a medicinal plant of India–Sarcostemma acidum. Int J Pharmacogn Phytochem Res. 2014; 6(4):690-697.
Reddy KN, Trimurthulu G, Reddy CS. Plants used by the ethnic people of Krishna district, Andhra Pradesh. Ind J
Trad Knowledge. 2010; 9(2):313-317.
Karuppusamy S. Medicinal plants used by Paliyan tribes of Sirumalai hills of southern India. Nat Prod Rad. 2007; 6(2):436-442.
Soni PK, Luhadia G, Sharma DK, Mali PD. Antifertility activates of traditional medicinal plants in male with emphasis on their mod active: A review. J Global Biosci. 2015; 4(1):1165-1179.
Sharma J, Gairola S, Gaur RD, Painuli RM, Siddiqi TO. Ethnomedicinal plants used for treating epilepsy by
indigenous communities of sub-Himalayan region of Uttarakhand, India. J Ethnopharmacol. 2013; 150(1):353-
Upadhyay B, Singh KP, Kumar A. Ethno-veterinary uses and informants consensus factor of medicinal plants of,
Sariska region, Rajasthan, India. J Ethnopharmacol. 2011; 133(1):14-25.
Mariappan SM and Sivashankaran P. Ethnomedicinal practices among a minority groups of Malayali tribes
residing in Vathal hills of Eastern Ghats. World J Pharmacocogn Pharm Sci. 2017; 6(6):1334-1350.
Gan L, Zhao X, Zhou C. Sarcidumitol, a new naturally occurring 2,6-dideoxy-disacchariditol from Sarcostemma
acidum. Chem Nat Comp. 2010; 46(1):5-6.
Savithramma N, Yugandhar P, Devi PS, Ankanna S, Damai S, Koya SP. Documentation of ethnomedicinal information and antimicrobial validation of Thespesia populnea used by Yanadi tribe of Ganugapenta village, Chittoor district, Andhra Pradesh, India. J Int Ethnopharmacol. 2017; 6(2):158-169.
Bhaskar V and Kushalappa CG. Siddarabetta in Tumakuru district, Karnataka - A rich biodiversity heritage site and the hill that heals. J Forest Allied Sci. 2015; 51(1):15-36.
Meerabai G. Plants used as antivenin by traditional healers of Rayalaseema region, Andhra Pradesh. Ind J Drugs. 2014; 2(2):44-48.
Venkata RK, Reddy GT, Raju RR. Herbal remedies for eye infections used by the tribals of Nallamala forests, Andhra Pradesh. Ind J Trad Knowledge. 2010; 9(4):765-767.
Warrier PK, Nambiar VPK, Ramankutty C. Indian Medicinal Plants A Compendium of 500 Species. Orient
Longman Private Limited, Chennai; 1993; 394p.
Hu RS. Sarcostemma acidum (Roxb.) voigt. Hort Suburb Calcutt. Fl China; 1845; 542p.
Shah NC. The discovery and mystery of soma plant and its identification. Scitech J. 2014; 1(11):26-36.
Sinha BK and Dixit RD. Ethnobotanical studies on Sarcostemma acidum (Asclepipiadaceae) from Khargaon
district, Madhya Pradesh. Ethnobot. 2001; 13:116-117
Warrier PK, Nambiar VP, Ramankutty C. Indian Medicinal Plant: A Compendium of 500 Species. Hyderabad: V Orient Black Swan/Universities Press; 1996; 73-75p.
Khare DP, Tiwari SS, Khare A, Khare MP. Structure of brevobiose. Carbohydr Res. 1980; 79 (2):279-286.
Gan LS, Yang SP, Fan CQ, Yue JM. Lignans and their degraded derivatives from Sarcostemma acidum. J Nat
Prod. 2005; 68(2):221-225.
Kannan S, Vijayakumar B, Sureshkumar C, Mohankumar R, Narasimhan S. Insect antifeedant and growth regulating activities of β-amyrin from Sarcostemma acidum. Asian J Chem. 2013; 25(2):1167-1168.
Verma PK, Sharma A, Mathur A, Sharma P, Gupta RS, Joshi SC. Sarcostemma acidum stem extract on
spermatogenesis in male albino rats. Asian J Androl. 2002; 4(1):43-47.
Rathore MS and Shekhawat NS. In vitro regeneration in Sarcostemma acidum (Roxb.) -an important medicinal plant of semi-arid ecosystem of Rajasthan, India. Physiol Mol Biol Plants. 2013; 19(1):269-275.
Gulshan M, Chandrasekhar GNSS, Kumar BV, Ramarao N. Anti-Ulcer activity of Ethanolic Sarcostemma acidum stem extracts. Int Res J Pharm. 2017; 8(6):91-94.
Gupta S, Kohli S, Dwivedi S. In-vitro anti-inflammatory activity of Sarcostemma acidum Wight. & Arn. Indian herb by Human red blood cell membrane stabilization method. Int J Pharm Teaching Prac. 2011; 2 (4):184-188.
Mallam A, Angothu S, Gurajala S, Khuddus GA. Antimicrobial activity of Sarcostemma acidum Voigt. (Apocynaceae) stem. Int J BioPharm Res. 2012; 3(6):752-757.
Ittiyavirah SP and Rahees T. Evaluation of psychopharmacological activity of ethyl acetate extract of
Sarcostemma acidum (Roxb.) Voiget. J Psychopharmacol. 2013; 2(5):1-7.
Lalitha KG and Sethuraman MG. Phytochemical and pharmacological evaluation of theflowers of Sarcostemma
brevistigma Wight. Oriental Pharm Exp Med. 2009; 9(3):252-258.
Pandey S. Ethnomedicinal Potential of Sarcostemma acidum in different regions in India. Asian J Pharm Clin
Res. 2018; 11(5):395-400.
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