Effect of Basil Leaf Extract on Diabetes: A Systematic Review and Meta-Analysis

Sry S. Widjaja; Rusdiana; Maya Savira; Vito F. Jayalie; Metta Dewi

doi:10.26538/tjnpr/v8i2.2

Authors

Sry S. Widjaja Biochemistry Department, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia
Rusdiana Biochemistry Department, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia
Maya Savira Physiology Department, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia
Vito F. Jayalie Universitas Imelda Medan,Indonesia
Metta Dewi Universitas Indonesia, Indonesia

DOI:

https://doi.org/10.26538/tjnpr/v8i2.2

Keywords:

Animal, Diabetes, Meta-Analysis, Basil, Ocimum basilicum

Abstract

The pharmacological properties of basil (Ocimum basilicum L.) have been widely researched for its antidiabetic activity. However, its potency in lowering serum glucose levels is still under investigation. Determination of the effect of basil leaf extract as an antidiabetic drug was the aim of this systematic review. Literature searches were conducted using online databases for peerreviewed articles on basil extract in diabetic rats. A random effect model was used to pool the effect size. Seven studies were included in this review, and there was a statistically significant difference in plasma glucose levels between the diabetic group and the group with the Basil extract intervention. The most significant difference was observed at a concentration of 100 mg/kg (MD: −265.59; 95% CI: 419.49 to 111.69; p< 0.00001). Thus, it could be concluded that basil leaf extract can lower blood glucose levels in diabetic animal models.

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