A Mini Review on Some Known Medicinal Uses of Tridax procumbens: http://www.doi.org/10.26538/tjnpr/v7i8.1

Sarah A. Evbuomwan; Omolola. E Omotosho; Olusegun. O. Akinola

Authors

Sarah A. Evbuomwan Department of Biochemistry, Covenant University, Km 10, Idiroko Road, Sango Ota, Ogun State, Nigeria
Omolola. E Omotosho Department of Biochemistry, Covenant University, Km 10, Idiroko Road, Sango Ota, Ogun State, Nigeria
Olusegun. O. Akinola Department of Biochemistry, Covenant University, Km 10, Idiroko Road, Sango Ota, Ogun State, Nigeria

Keywords:

Cardioprotective, Hepatoprotective, Antioxidant, Antimicrobial, Wound healing, Anti-diabetic, Anti-hypertensive, Tridax procumbens

Abstract

Plants are a valuable source of medication and have a significant impact on global health. Medicinal herbs and plants have long been recognized as valuable sources of medicines and curative remedies. Medicinal plants are considered rich sources of ingredients that can be used for drug development. This has propelled scientists and researchers to investigate the use of medicinal plants for the treatment of various ailments. One of the plants with a wide variety of medicinal purposes is the Tridax procumbens plant. It is a highly potent plant that has many health benefits. Tridax procumbens is readily available and with all the medicinal benefits, it is still underutilized due to lack of or insufficient awareness. This study is aimed at reviewing the anti-hypertensive, anti-diabetic, wound healing, antimicrobial, antioxidant, hepatoprotective, and cardioprotective potentials of the Tridax procumbens plant. Google Scholar, Elsevier, NCBI, and PubMed databases were searched from 2009 to 2023 using specific keywords. Searching was done only
using the English language. Thirty-six (36) articles were evaluated in this review. Most of the research articles included in this review supported the claims. It was concluded that this plant has medicinal properties due to the bioactive compounds it contains which help to ameliorate many health conditions.

References

Rana D, Bhatt A, Lal B, Parkash O, Kumar A, Uniyal SK. Use of medicinal plants for treating different ailments by the indigenous people of the Churah subdivision of district Chamba, Himachal Pradesh, India. Environ Dev Sustain. 2020;1-80.

Okwu DE. Phytochemical and Vitamin Content of Indigenous Species of South-Eastern Nigeria. J Sustain Agric Environ. 2004; 6:30-37.

Sandberg F, Corrigan D. Natural remedies: their origins and uses. 2003 CRC Press.

Oladeji O. The characteristics and roles of medicinal plants: Some important medicinal plants in Nigeria. Nat Prod Ind J. 2016;12(3):102.

Harborne JB, Baxter H, Webster FX. Phytochemical dictionary: a handbook of bioactive compounds from plants. J. Chem Ecol. 1994;20(3):815-8.

Le Bourgeois T, Grard P, Andrianaivo AP, Gaungoo A, Ibrahim Y, Randriamampianina JA, Dhandapani B, Marcotte P, Blandford V, Rajagopal P, Vattakaven T, Kazi TC. 2019. WIKTROP - Weed Identification and Knowledge in the Tropics and Mediterranean area - Web 2.0 participatory

portal. European Union programme ACP S&T II, Cirad, IFP, MCIA/MSIRI, FOFIFA, CNDRS eds.http://portal.wiktrop.org

Breslin A. The chemical composition of green plants. Sciencing. Leaf Group Ltd. 2017;76.

Molyneux RJ, Lee ST, Gardner DR, Panter KE, James LF. Phytochemicals: the good, the bad and the ugly?. Phytochemistry. 2007;68(22-24):2973-85.. doi:10.1016/j.phytochem.2007.09.004. PMID 17950388.

USDA, NRCS (n.d.). "Tridax procumbens". The PLANTSDatabase (plants.usda.gov). Greensboro, North Carolina: National Plant Data Team. Retrieved 15 December 2015.

Holm L, Doll J, Holm E, Pancho JV, Herberger JP. World weeds: natural histories and distribution. John Wiley & Sons; 1997;862.

Seena KK, Nishma M. Tridax procumbens (l); A Pharmacognostic Screening. Int J Curr Res. 2017; 9(11): 60239-60242.

Kaushik D, Tanwar A, Davis J. Ethnopharmacological and Phytochemical Studies of Tridax procumbens Linn: A Popular Herb in Ayurveda Medicine. Int. J. Eng. Res. 2020; 9:758-68.

Beck S, Mathison H, Todorov T, Calder E, Kopp OR. A review of medicinal uses and pharmacological activities of Tridax procumbens (L.). J Plant Stud. 2018;7(1):19.

Mecina GF, Chia MA, Cordeiro-Araújo MK, do Carmo Bittencourt-Oliveira M, Varela RM, Torres A, Molinillo JM, Macías FA, da Silva RM. Effect of flavonoids isolated from Tridax procumbens on the growth and toxin production of Microcystis aeruginos. Aquat Toxicol. 2019; 211:81-91.

Chen WH, Ma XM, Wu QX, Shi YP. Chemical-constituent diversity of Tridax procumbens. Can J Chem. 2008; 86(9):892-8.

Xu R, Zhang J, Yuan K. Two new flavones from Tridax procumbens Linn. Mol. 2010; 15(9):6357-64.

Ma S, Zhou JM, Wei HS, Wu HB. Flavones from the flowers of Tridax procumbens and their antioxidant activity. Chem. Nat. Compd. 2020; 56:239-41.

Vickers NJ. Animal communication: when I’m calling you, will you answer too? Curr Biol. 2017; 27(14):R713-5.

Jude IC, Catherine IC, Frank OC. Effect of aqueous extract of Tridax procumbens Linn on plasma electrolytes of salt loaded rats. PJN. 2010; 9(2), 103-105.

Salahdeen HM, Idowu GO, Salami SA, Murtala BA, Alada AA. Mechanism of vasorelaxation induced by Tridax procumbens extract in rat thoracic aorta. J Intercult Ethnopharmacol. 2016; 5(2), 174–179.

Salahdeen HM, Idowu GO, Murtala BA. Endotheliumdependent and independent vasorelaxant effects of aqueous extract of Tridax procumbens Lin. leaf in rat aortic rings. Indian J Exp Biol. 2012; 50(12):883-8. PMID: 23986972.

Salahdeen HM, Salami SA, Paul CO, Murtala BA, Alada AA. Biochemical parameters as indicators of the antihypertensive efficacy of leaf aqueous extract of Tridax procumbens (Lin) in L-NAME induced hypertensive rats. J Mol Pathophysiol. 2017; 6(2), 30-37.

Salami SA, Salahdeen HM, Idowu GO, Murtala BA, Alada ARA. Tridax procumbens leaf extract elicits relaxation of rat mesenteric artery by activation of Na+ -K+ ATPase / Na+ -Ca2+ exchanger. Natl J Physiol Pharm Pharmacol. 2021;11 (Online First). DOI: 10.5455/

njppp.2021.11.12351202113042021.

Das B, Talekar YP, Paul T, Talekar D, Apte KG, Parab P. Evaluation of wound healing potential of aqueous and ethanolic extracts of Tridax procumbens Linn in Wistar rats. Asian J Pharm Clin Res. 2012; 5, 141-145.

Ravindran J, Arumugasamy V, Baskaran A. Wound healing effect of silver nanoparticles from Tridax procumbens leaf extracts on Pangasius hypophthalmus. Wound Med 2019; 27(1), 100170.

Shrivastav A, Mishra AK, Abid M, Ahmad A, Fabuzinadah M, Khan NA. Extracts of Tridax procumbens Linn leaves cause wound healing in diabetic and Non-diabetic laboratory animals. Wound Med. 2020; 29:100185.

Deshmukh R, Agrawal R, Chauragde S, Lilhare S, Mishra MU. Formulation and evaluation of ointment containing natural wound healing activity of Tridax procumbens. Res J Pharm Technol 2018; 11(10):4543-4546.

Ambulkar S, Ambulkar P, Deshmukh MP, Budhrani AB. Experimental evaluation of wound healing activity of various dosage forms of Tridax procumbens. Indian J. Forensic Med Toxicol. 2020; 14(4):6579-84.

Pai C, Kulkarni U, Borde M, Murali S, Mrudula P, Deshmukh Y. Antibacterial Activity of Tridax procumbenswith Special Reference to Nosocomial Pathogens. J Pharm Res Int. 2011; 1(4):164-173.

Bharathi V, Varalakshmi B, Gomathi S, Shanmugapriya A, Karpagam T. Antibacterial activity of Tridax procumbensLinn. Int J Pharma Sci Res. 2012; 3(4), 364-7.

Pandey M, Pandey A, Kumar R, Pathak A, Dikshit A. Comparative antimicrobial analysis of Tridax procumbens L. various extracts on waterborne bacterial pathogens. Int. Curr. Pharm. J. 2016; 5(3):22-6.

Tejaswini K, Vishwanath PB, Rudrama DK, Shylaja S, Jyothsna, K. Phytochemical screening and antimicrobial activities of plant extract of Tridax procumbens. Bioscan. 2011; 6(2):321-323.

Policegoudra RS, Chattopadhyay P, Aradhya SM, Shivaswamy R, Singh L, Veer V. Inhibitory effect of Tridax procumbens against human skin pathogens. J Herb Med. 2014; 4(2):83-88.

Syed A, Benit N, Alyousef AA, Alqasim A, Arshad M. Invitro antibacterial, antioxidant potentials and cytotoxic activity of the leaves of Tridax procumbens. Saudi J Biol Sci 2020; 27(2):757-761.

Andriana Y, Xuan TD, Quy TN, Minh TN, Van TM, Viet TD. Antihyperuricemia, antioxidant, and antibacterial activities of Tridax procumbens L. Foods. 2019; 8(1):21.

Bhagwat DA, Killedar SG, Adnaik RS. Anti-diabetic activity of leaf extract of Tridax procumbens. IJGP. 2008; 2(2):126-128.

Pareek H, Sharma S, Khajja BS, Jain K, Jain GC. Evaluation of the hypoglycemic and anti-hyperglycemic potential of Tridax procumbens (Linn.). BMC Complement Altern Med. 2009; 9(1):1-7.

Petchi RR, Parasuraman S, Vijaya C. Antidiabetic and antihyperlipidemic effects of an ethanolic extract of the whole plant of Tridax procumbens (Linn.) in streptozotocininduced diabetic rats. JBCP. 2013; 4(4):88.

Sonawane A, Srivastava RS, Sanghavi N, Malode Y, Chavan B. Anti-diabetic activity of Tridax procumbens. J Sci Innov Res. 2014; 3(2):221-226.

Desai GS, Desai SV, Gavaskar RS, Mulabagal V, Wu Y, Mathews ST. Blood Glucose-lowering Effect of T. procumbens L.: A Pilot Clinical Study in Individuals with Type 2 Diabetes. PTR. 2015; 29(9):1404–1411.

Amagbegnon JB, Koukoui O, Agbangnan PC, Seton S, Betira M, Medegan S, Loko L, Dougnon V, Djogbenou L, Sezan A. Evaluation of the Preventive and Therapeutic Activities of Tridax procumbens against Hyperglycemia and Hyperlipidemia Induced in Wistar Rats. Pharm Pharmacol. 2021; 12(7):127-40.

Kakkar M, Behl T, Cruz CV, Makeen HA, Albratty M, Alhazmi HA, Meraya AM, Albadrani GM, Abdel-Daim MM. Tridax procumbens ameliorates streptozotocin-induced diabetic neuropathy in rats via modulating angiogenic, inflammatory, and oxidative pathways. eCAM. 2022; 31.

Habila JD, Bello IA, Dzikwi AA, Musa H, Abubakar N. Total phenolics and antioxidant activity of Tridax procumbens Linn. Afr J Pharm Pharmacol. 2010; 4(3):123-126.

Agrawal SS, Talele GS, Surana SJ. Antioxidant activity of fractions from Tridax procumbens. J Pharm Res. 2009;2(1):71-73.

Singh P, Jain K, Khare S, Shrivastav P. Evaluation of phytochemical and antioxidant activity of Tridax procumbens extract. UKJPB. 2017; 5(6):41-47.

Suryawanshi HP, Jain A, Pawar SP. A descriptive study and in-vitro antioxidant activity of leaves extracts of Tridax procumbens Linn. J. Med Pharm Allied Sci. 2021; 1(1905):1-4.

Wagha SS, Shinde GB. Investigation of hepatoprotective and antioxidant activity of Tridax procumbens Linn (Asteraceae) extract against rifampicin-induced hepatotoxicity in male albino rats. Mater Today: Proc. 2018; 5(10):22605-22613.

Sagheer R, Singh R, Nasibullah M, Ansari JA, Srivastava SK, Mahdi AA. Exploration of hepatoprotective potential of methanolic extract of Tridax procumbens against isoniazidrifampicin induced toxicity in albino rats. J Pharmacogn Phytochem. 2018; 7(3):384-390.

Chandra AS, Shanmugapandiyan P. Hepatoprotective effect on methanolic extracts of Tagetes erecta leaves and Tridax procumbens against drug-induced hepatic injury. Int J. Res Pharm Sci. 2021; 12(2):1415-1421.

Ravikumar V, Shivashangari KS, Devaki T. Hepatoprotective activity of Tridax procumbens against d-galactosamine/lipopolysaccharide-induced hepatitis in rats. J Ethnopharmacol. 2005;101(1-3):55-60. doi: 10.1016/j.jep.2005.03.019. PMID: 15923095.

Wagh SS, Shinde GB. Antioxidant and hepatoprotective activity of Tridax procumbens Linn, against paracetamolinduced hepatotoxicity in male albino rats. Adv Stu Biol. 2010; 2:105-2.

Ramachandran V, Kumar GV, Sugumar S, Sundaram V, Ahamed HN. Cardioprotective effect of Tridax procumbensLinn in Isoproterenol Induced Myocardial Infarction in rats. Res J Pharm Technol. 2020; 13(4):1921-1925.

Shanmugapriya A, Maneemegalai S. Evaluation of synergistic potential of Tridax procumbens and Boerhavia diffusa in isoproterenol-induced myocardial injury. IABMS 2019; 39(4):555-560.

Ikewuchi JC, Ikewuchi CC, Ifeanacho MO, Jaja VS, Okezue EC, Jamabo CN, Adeku KA. Attenuation of doxorubicininduced cardiotoxicity in Wistar rats by aqueous leaf extracts of Chromolaena odorata and Tridax procumbens. J Ethnopharmacol. 2021; 274, 114004.

InformedHealth.org [Internet]. Cologne, Germany: Institute for Quality and Efficiency in Health Care (IQWiG); 2006-. What is blood pressure and how is it measured? 2010 Jun 24 [Updated 2019 May 23]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK279251/

Neeraj JP, Singh S, Singh J. Role of free radicals and antioxidants in human health and disease. IJCRR. 2013; 5 (19):14-22.

Omotosho, OE, Iheagwam FN, Noiki IA, Omini JJ. Comparative Study on Chemical Composition and Antioxidant Activity of Annona muricata Plant Parts Cultivated in Covenant University, Ota, Ogun State, Nigeria. Curr Res Nutr Food Sci. 2018; 6(3), 807-815.

Ogunlana OE, Ogunlana O, Farombi OE. Assessment of the scavenging activity of crude methanolic stem bark extract of Newbouldia laevis on selected free radicals. Adv Nat Appl Sci. 2008; 2(3):249-54.

Singh R. Medicinal plants: A review. J Plant Sci. 2015; 18 3(1-1):50-5.

Obode OC, Adebayo AH, Omonhinmin CA, Yakubu OF. A systematic review of medicinal plants used in Nigeria for hypertension management. Int J Pharm Res. 2020; 12(4):1-46.

Satish AB, Tushar SK. Phytochemical and pharmacological potential of Tridax procumbens Linn. Int J Adv Biotechnol Res. 2012; 2:392-5.

Himanshu CC, Kiran PP. A Review on Medicinal Importance of Tridax procumbens Linn. RROIJ. 2022; 11:2. e-ISSN:2320-1215

Ingole VV, Mhaske PC, Katade SR. Phytochemistry and pharmacological aspects of Tridax procumbens (L.): a systematic and comprehensive review. Phytomedicine Plus. 2022; 2(1):100199.

Neangthaisong T, Rattanakiat S, Phimarn W, Joeprakhon S, Saramunee K, Sungthong B. Local Wisdom and Medicinal Plant Utilization of Certified Folk Healers for Therapeutic Purposes in Buriram Province, Thailand: TJNPR. 2023;5(4):678-85. doi.org/10.26538/tjnpr/v5i4.15