Protective Effects of Curcumin against Nicotine-Induced Damage on Esophagus Tissue in the Wister Rat
http://www.doi.org/10.26538/tjnpr/v7i6.6
Keywords:
Histopathology, Antioxidants, Waterpipe smoking, CurcuminAbstract
Curcumin has been used in folk medicine for thousands of years as a food and traditional medicine. It is renowned for its antibacterial and antioxidant properties. This study assesses the potential impact of waterpipe smoking on the esophageal tissues of Wister rats (Rattus norvegicus). Furthermore, it aimed to investigate curcumin's efficacy in reducing cytotoxicity induced by tobacco smoking. A total of 27 Wister male adult rats were separated into three groups first acted as a control, the second group smoked, and the third group received daily intraperitoneal injections of 40 mg/kg of curcumin. Additionally, the rats were exposed to waterpipe smoking using a smoking machine for 30 days before dissecting the rat; serum samples were collected to measure enzyme activity. The esophagus was then isolated and prepared for light microscopy analysis. According to the findings of this study, it has been demonstrated that curcumin effectively decreased the activity of liver enzymes (AST, ALT, and LDH) which reduced the harmful effects
of waterpipe smoking in rats. Treatment of curcumin with exposure to WPS showed a reduction in the thickness of the keratin layer with less inflammation in comparison to the waterpipe only; the results indicate that curcumin has a protective impact.
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