Pharmaceutical Stability of Brands of Paracetamol Tablets under Different Environmental Conditions
doi.org/10.26538/tjnpr/v3i5.1
Keywords:
paracetamol, drug content, degradation, environmental conditions, StabilityAbstract
Drugs are exposed to some conditions which are inevitable in the shelf-life of those drugs. Such conditions are met during drug distribution to the point of consumption. If stability of a drug product is not maintained throughout its shelf-life, quality, safety, potency and efficacy will be compromised. This study aimed to investigate the effect of these conditions on the pharmaceutical stability of paracetamol tablet formulations. Three brands of paracetamol tablets were stored in their original packages under different environmental conditions (living room, kitchen, out-door and trunk of a car) for 24 months. Samples were withdrawn at different time intervals and evaluated for variations in weight, diameter, hardness, friability, content uniformity and disnegration and dissolution. One-way ANOVA and student t-test were used to compare difference in data. Organoleptic properties of the tablets were maintained for the 24 months except the brands kept out-door which had an off white colouration. Drug degradation was minimal with the paracetamol packaged in PVC blisters. The pharmaceutical stability of the three products in the living room and in the kitchen at 24 months was not adversely affected while those kept out- door and in the trunk of a saloon car was adversely affected.
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