Potentials of Pisum sativum Extract and Cocos nucifera Water in Mitigating Lead Toxicity in Body Weight and Serum Lipid Profile of Rat Model: doi.org/10.26538/tjnpr/v6i2.8

Ben  J. Enagbonma; Ekaye Sese-Owei; Emmanuel E. Imade; Israel O. Okoduwa; Asemota A. Joanne

Authors

Ben J. Enagbonma Department of Environmental Management and Toxicology, Faculty of Life Sciences, University of Benin, P.M.B 1154, Benin City, Nigeria
Ekaye Sese-Owei Department of Animal and Environmental Biology, Faculty of Life Sciences, University of Benin, P.M.B 1154, Benin City, Nigeria
Emmanuel E. Imade Department of Microbiology, Faculty of Life Sciences, University of Benin, P.M.B 1154, Benin City, Nigeria
Israel O. Okoduwa Department of Microbiology, Faculty of Life Sciences, University of Benin, P.M.B 1154, Benin City, Nigeria
Asemota A. Joanne Department of Environmental Management and Toxicology, Faculty of Life Sciences, University of Benin, P.M.B 1154, Benin City, Nigeria

Keywords:

Atherosclerosis, Cardiovascular disorder, Lead nitrate, Medicinal plant

Abstract

Many studies have recommended using plants and their extracts for abating heavy metals from cells and tissues. Most of these recommendations are, however, based on the rich antioxidant properties in them. Thus, this study investigated Pisum sativum extract (PS) and Cocos nucifera water's (CN) ameliorative potentials on the alterations in body weight and serum lipid profile of rats induced by lead nitrate (Pb(NO3)2). Lipid profile analyses were done on the serum collected from blood samples of forty-eight healthy albino rats (distributed into eight groups of 6 rats each) of average weight 154 g. This experiment lasted for 18 weeks and at the end of 3 weeks,one rat from each group was sacrificed. Results showed that the average values of total cholesterol, triglyceride, LDL-ch, coronary risk index, and LDL/HDL-ch significantly increased in rats administered with only (Pb(NO3)2) compared with rats in the control groups. Also, a significant reduction in the mean value of HDL-ch and body weight was observed in the group of rats administered with only (Pb(NO3)2) compared to the group of rats in the control groups. Furthermore, a decrease in the total cholesterol, triglyceride, LDL-ch, coronary risk index, and LDL/HDL-ch was observed from this study. In contrast, the mean value of HDL-ch and body weight of the rats increased when co-treated with PS and CN, especially in the combined form. Thus, this study showed that PS and CN have the potentials to ameliorate the alterations in body weight and lipid profile of the rat model induced by (Pb(NO3)2).

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