The Synergistic Role of Zingiber officinale, Curcuma longa, Garcinia kola Tract on Immunological and Hematological Indices of Albino Rats Previously  Immunosuppressed with Cyclophosphamide: doi.org/10.26538/tjnpr/v6i2.14

Godfrey  I Iyare; Nosa T. Omorodion; Peter U. Achukwu

Authors

Godfrey I Iyare Department of Medical Laboratory Science, Faculty of Health Sciences, College of Medical Sciences, University of Nigeria, Enugu Campus, Nigeria
Nosa T. Omorodion Department of Medical Laboratory Sciences, School of Basic Medical Sciences, College of Medicine University of Benin, Benin city, Nigeria
Peter U. Achukwu Department of Medical Laboratory Science, Faculty of Health Sciences, College of Medical Sciences, University of Nigeria, Enugu Campus, Nigeria

Keywords:

Cyclophosphamide, Combine extract, Haematological effect, Immunological effect

Abstract

Herbal medicine has been in use for a long time and it is still being used by people all over the world. The purpose of this study was to assess the immunological effect of Zingiber officinale, Curcuma longa, Garcinia kola extract in Albino rats. A total of 46 albino rats were used in this study. The study was divided into two phases, phase one was divided into two groups A (six rats) and B (40 rats, sub-divided into 5 cages of eight rats each). Group A, received pelleted rat feed and water, whereas group B received cyclophosphamide for five weeks after which 12 of the 40 rats were sacrificed and the blood sample taken for examination. In the second phase, the remaining 28 rats were divided into seven groups (A to G), with A serving as control and received water and rat pellets while B, C, D, E, F and G received 600 mg/kg of Zingiber officinale, 600 mg/kg of Curcuma longa 600 mg/kg of Garcinia kola 600 mg/kg of Combine extract, 1200 mg/kg of combine extract, and 2400 mg/kg of combined extract, respectively. After six weeks duration, all Animals were weighed, anaesthetized with chloroform and blood samples were collected for immunological and Hematological analysis. In stage 1, there was significant reduction in the immunological and hematological indices, while in stage 2 there were significant increased (P< 0.005) in body weight, immunological, hematocrit and hematological indices. In this study, the combined herbal medicine showed reversal effect on immunosuppressed rats.

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