Alterations in Biochemical Parameters and Antioxidant Enzymes in Male Mice as Biomarkers of Exposure to Pollution with Cadmium
http://www.doi.org/10.26538/tjnpr/v6i11.8
Keywords:
Cadmium toxicity, Liver function, Renal dysfunction, Antioxidant enzymesAbstract
There is currently a significantly larger concentration of toxins in our environment than there was in the past. This is mostly ttributable to the expansion of modern industry. This investigation was conducted in order to investigate various haematological and biochemical
changes in order to determine the effects of Cd on the liver and kidney. Because of its long biological half-life, it is considered hazardous to human health. The effect of sub-lethal doses (40, 80 and 120 mg\Kg) of Cadmium (Cd) on male mice were evaluated for 4 weeks, and analysis was done to estimate their biochemical parameters and antioxidant enzymes. The results showed that Cd-treated mice had considerably lower packed cell volume, red blood cells, and haemoglobin. White blood cells, on the other hand, showed a considerable rise at the higher dosages. All of the treatment groups showed considerable improvements in kidney functions compared to the control group, especially with respect to creatinine and urea. All dosages significantly increased aspartate aminotransferase and alanine transaminase levels. Contrarily, only the second and third treatments showed a substantial rise in malondialdehyde levels and
antioxidant enzymes (catalase and superoxide dismutase). In conclusion, Cd-induced oxidative stress in an organism alters various biochemical parameters and antioxidant enzymes, which can be employed as biomarkers for Cd contamination.
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