Hepatoprotective Effect of Ethanol Leaf Extract of Ficus thonningii (Blume) against Carbon Tetrachloride (CCl4)-Induced Hepatotoxicity in Wistar Rats
doi.org/10.26538/tjnpr/v4i8.15
Keywords:
Hepatotoxicity, Wistar rats, Carbon tetrachloride (CCl4), Ficus thonningii (Blume)Abstract
Drug-induced liver injury is a potential complication of virtually all medications because the liver has a central role in the metabolism of drugs and toxic substances The study aimed to evaluate the hepatoprotective activity of the ethanol leaf extract of F. thonningii (Blume) against carbon tetrachloride (CCl4)-induced liver damage in Wistar rats. The hepatoprotective effect was assessed by evaluating the biochemical parameters and histopathological examination of the liver of treated and control animals. The hytochemical constituents of the extract was further studied using Gas Chromatography-Mass Spectrometry (GC-MS) analysis. The results showed
that the hepatoprotection of the extract was confirmed by the significant (P < 0.05) decrease in the serum levels of the Alanine aminotransferase (ALT), Aspartate aminotransferase (AST), Alkaline phosphatase (ALP), and Total bilirubin (TB) especially at higher doses. Histopathological examination revealed cytolysis in the liver of untreated animals, while treated animals showed typical standard liver architecture. The GC-MS analysis revealed the presence of palmitic acid, phytol, oleic acid, iconic acid, 9,12-Octadecadienoic acid, and 9-Octadecenal. Findings of this study substantiate the folkloric use of F. thonningii in the management of
hepatic ailments.
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