Methanol Extract of Ficus platyphylla Stem Bark Inhibits Cholinesterase Enzyme on Catfish
doi.org/10.26538/tjnpr/v4i10.27
Abstract
Traditional medicinal plants have been used for many years by different cultures around the
world for the management of different diseases. Current treatments of neurodegenerative
diseases are not effective and result in several side effects. Thus, the search for alternative
medicines is in high demand. Therefore, this study aim to evaluate the cholinesterase inhibitory
effect of Ficus platyphylla 80% methanol (stem bark) extracts. The stem bark was extracted with
80% methanol. A toxicity study was carried out on adult Catfish. Cholinesterase inhibitory
activities were also evaluated on the same fishes using Ellman’s method. Result revealed high
cholinesterase inhibitory activity of the crude extract with high significant differences at P <
0.001 between the group that was treated with crude extract only, group treated with crude
extract, and exposed to arsenic and group that were exposed to arsenic only as well as the group
that were maintained in complete media. It can be concluded that the low toxicity and high
cholinesterase inhibitory effect of the crude extract could be responsible for its therapeutic
effects. Toxicity screening of this crude extract on a mammal such as mice and rat to reaffirm
their toxicity and antioxidant screening as well as isolation of bioactive compounds present in
this plant part is strongly recommended.
Keyword: Arsenic, Cholinesterase, Extracts, Catfish, Toxicity Study
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