Methanol Extract of Ficus platyphylla Stem Bark Inhibits Cholinesterase Enzyme on Catfish doi.org/10.26538/tjnpr/v4i10.27

Main Article Content

Ibrahim M. Hassan
Abdullahi I. Ja’afaru

Abstract

Traditional medicinal plants have been used for many years by different cultures around the
world for the management of different diseases. Current treatments of neurodegenerative
diseases are not effective and result in several side effects. Thus, the search for alternative
medicines is in high demand. Therefore, this study aim to evaluate the cholinesterase inhibitory
effect of Ficus platyphylla 80% methanol (stem bark) extracts. The stem bark was extracted with
80% methanol. A toxicity study was carried out on adult Catfish. Cholinesterase inhibitory
activities were also evaluated on the same fishes using Ellman’s method. Result revealed high
cholinesterase inhibitory activity of the crude extract with high significant differences at P <
0.001 between the group that was treated with crude extract only, group treated with crude
extract, and exposed to arsenic and group that were exposed to arsenic only as well as the group
that were maintained in complete media. It can be concluded that the low toxicity and high
cholinesterase inhibitory effect of the crude extract could be responsible for its therapeutic
effects. Toxicity screening of this crude extract on a mammal such as mice and rat to reaffirm
their toxicity and antioxidant screening as well as isolation of bioactive compounds present in
this plant part is strongly recommended.
Keyword: Arsenic, Cholinesterase, Extracts, Catfish, Toxicity Study

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How to Cite
Hassan, I. M., & Ja’afaru, A. I. (2020). Methanol Extract of Ficus platyphylla Stem Bark Inhibits Cholinesterase Enzyme on Catfish: doi.org/10.26538/tjnpr/v4i10.27. Tropical Journal of Natural Product Research (TJNPR), 4(10), 824-830. https://www.tjnpr.org/index.php/home/article/view/1090
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How to Cite

Hassan, I. M., & Ja’afaru, A. I. (2020). Methanol Extract of Ficus platyphylla Stem Bark Inhibits Cholinesterase Enzyme on Catfish: doi.org/10.26538/tjnpr/v4i10.27. Tropical Journal of Natural Product Research (TJNPR), 4(10), 824-830. https://www.tjnpr.org/index.php/home/article/view/1090

References

Salleh A, Naomi R, Utami ND, Mohammad AW, Mahmoudi E, Mustafa N, Fauzi MB. The Potential of Silver Nanoparticles for Antiviral and Antibacterial Applications: A Mechanism of Action. Nanomater. 2020; 10(8):1566.

Dizaji BF, Khoshbakht S, Farboudi A, Azarbaijan MH, Irani M. Far-reaching advances in the role of carbon nanotubes in cancer therapy. Life Sci. 2020; 257:118059.

Rosito M, Testi C, Parisi G, Cortese B, Baiocco P, Di Angelantonio S. Exploring the Use of Dimethyl Fumarate as Microglia Modulator for Neurodegenerative Diseases Treatment. Antioxid. 2020; 9(8):700.

Baker TL, Sun M, Semple BD, Tyebji S, Tonkin CJ, Mychasiuk R, Shultz SR. Catastrophic consequences: can the feline parasite Toxoplasma gondii prompt the purrfect neuroinflammatory storm following traumatic brain injury?. J Neuroinflamm. 2020; 17(1):1-9.

Malami I, Jagaba NM, Abubakar IB, Muhammad A, Alhassan AM, Waziri PM, Yahaya IZ, Mshelia HE, Mathias SN. Integration of medicinal plants into the traditional system of medicine for the treatment of cancer in Sokoto State, Nigeria. Heliyon 2020; 6(9):e04830.

Epoh NJ, Dongmo OL, Tchouanguep FM, Telefo PB. Ethnobotanical Study of Medicinal Plants used as AntiObesity Remedies in Foumban and Dschang Cities (WestCameroon). Eur J Med Plants 2020; 20:54-70.

Sharifi-Rad M, Lankatillake C, Dias DA, Docea AO, Mahomoodally MF, Lobine D, Chazot PL, Kurt B, Boyunegmez Tumer T, Catarina Moreira A, Sharopov F. Impact of Natural Compounds on Neurodegenerative Disorders: From Preclinical to Pharmacotherapeutics. J Clin Med. 2020; 9(4):1061.

Leyva-Jiménez FJ, Ruiz-Malagón AJ, Molina-Tijeras JA, Diez-Echave P, Vezza T, Hidalgo-García L, LozanoSánchez J, Arráez-Román D, Cenis JL, Lozano-Pérez AA, Rodríguez-Nogales A. Comparative Study of the Antioxidant and Anti-Inflammatory Effects of Leaf Extracts from Four Different Morus alba Genotypes in High Fat Diet-Induced Obesity in Mice. Antioxid. 2020; 9(8):733.

Oliaee D, Niazkar HR, Abbasnezhad A, Ghorbani M, Alavi Shahri PS, Saghaee Shahri S, Ghanaiyan K. The Effects of Medicinal Plants on Pancreatic Beta Cells in Diabetes: A Systematic Review of Iranians’ Contributions. Rev Clin Med. 2020; 7(1):30-36.

Olanrewaju AN, Kareen OK, Oforishe PO. Proximate and micronutrient composition of Bayad (Bagrus bajad) and upside-down catfish (Synodontis resupinatus) from Lake Alau, Nigeria. Anim Res Int. 2020; 17(2):3706-3712.

Kolbadinezhad SM, Coimbra J, Wilson JM. Is the dendritic organ of the striped eel catfish Plotosus lineatus an ammonia excretory organ?. Comparative Biochemistry and Physiology Part A: Mol Integr Physiol. 2020; 241:110640.

Patoka J, Takdir M, Aryadi H, Jerikho R, Nilawati J, Tantu FY, Bohatá L, Aulia A, Kamal MM, Wardiatno Y, Petrtýl M. Two species of illegal South American sailfin catfish of the genus Pterygoplichthys well-established in Indonesia. Knowl Manag Aqua Ecosys. 2020; 421(421):28.

Menéndez-Pedriza A and Jaumot J. Interaction of Environmental Pollutants with Microplastics: A Critical Review of Sorption Factors, Bioaccumulation and Ecotoxicological Effects. Toxics. 2020; 8(2):40.

Zheng X, Yan Z, Liu P, Fan J, Wang S, Wang P, Zhang T. Research Progress on Toxic Effects and Water Quality Criteria of Triclosan. Bull Environ Cont Toxicol. 2019; 102(6):731-740.

Fürst P, Milana MR, Pfaff K, Tlustos C, Vleminckx C, Arcella D, Torres RR. Risk evaluation of chemical contaminants in food in the context of RASFF notifications: Rapid Assessment of Contaminant Exposure tool (RACE). EFSA, 2019; 16 (5):1625E.

Venil CK, Khasim AR, Aruldass CA, Ahmad WA. Safety evaluation of flexirubin from Chryseobacterium artocarpi CECT 8497: Acute, sub-acute toxicity and mutagenicity studies. Proc Saf Environ Prot. 2017; 112:362-370.

Suganthy N, Ramkumar VS, Pugazhendhi A, Benelli G, Archunan G. Biogenic synthesis of gold nanoparticles from Terminalia arjuna bark extract: assessment of safety aspects and neuroprotective potential via antioxidant, anticholinesterase, and antiamyloidogenic effects. Environ

Sci Pollut Res. 2018; 25(11):10418-10433.

Lancia JP, Fernandez GA, Bas C, Spivak E. Adaptive differences in digestive enzyme activity in the crab Neohelice granulata in relation to sex and habitat. J Crust Biol. 2012; 32(6):940-948.

Hassan I, Wan IWN, Yusuf FM, Ahmad SA, Ahmad S. Biochemical Constituent of Ginkgo biloba (Seed) 80% Methanol Extract Inhibits Cholinesterase Enzymes in Javanese Medaka (Oryzias javanicus) Model. J Toxicol, 2020; 2020:1-11.

Guyot AC, Leuxe C, Disdier C, Oumata N, Costa N, Le Roux G. Pavoni S. A small compound targeting prohibitin with potential interest for cognitive deficit rescue in aging mice and tau pathology treatment. Sci Rep. 2020; 10(1):1- 16.

Mehta A, Dalle VE, Isert L, Merkel OM. Targeting KRAS mutant lung cancer cells with siRNA-loaded bovine serum albumin nanoparticles. Pharm Res. 2019; 36(9):133.

Ekin HN, Orhan DD, Orhan İE, Orhan N, Aslan M. Evaluation of enzyme inhibitory and antioxidant activity of some Lamiaceae plants. J Res Pharm. 2019; 23(4):749-758.

Ullah R, Khan M, Shah SA, Saeed K, Kim MO. Natural antioxidant anthocyanins—A hidden therapeutic candidate in metabolic disorders with major focus in neurodegeneration. Nutr. 2019; 11(6):1195.

Jafar TH, Ramakrishnan C, John O, Tewari A, Cobb B, Legido-Quigley H, Sungwon Y, Jha V. Access to CKD Care in Rural Communities of India: a qualitative study exploring the barriers and potential facilitators. BMC Nephrol. 2020; 21(1):26.

Jafari H, Lista A, Siekapen MM, Ghaffari-Bohlouli P, Nie L, Alimoradi H, Shavandi A. Fish Collagen: Extraction, Characterization, and Applications for Biomaterials Engineering. Polym. 2020; 12(10):2230.

Lakka A, Grigorakis S, Karageorgou I, Batra G, Kaltsa O, Bozinou E, Lalas S, Makris DP. Saffron processing wastes as a bioresource of high-value added compounds: Development of a green extraction process for polyphenol recovery using a natural deep eutectic solvent. Antioxid.

; 8(12):586.

Mogole L, Omwoyo W, Mtunzi F. Phytochemical screening, anti-oxidant activity and α-amylase inhibition study using different extracts of loquat (Eriobotrya japonica) leaves. Heliyon 2020; 6(8):e04736.

Nowrouzi I, Mohammadi AH, Manshad AK. Effects of methanol and acetone as mutual solvents on wettability alteration of carbonate reservoir rock and imbibition of carbonated seawater. J Pet Sci Engr. 2020; 195:107609.

Lolita T, Ruta G, Zanda K, Ingmars C. Characterization of dried horseradish leaves pomace: phenolic compounds profile and antioxidant capacity, content of organic acids, pigments and volatile compounds. Eur Food Res Technol. A. 2020; 246(8):1647-1660.

Awotedu OL, Okeke UE, Ogunbamowo PO, Ariwoola OS, Omolola TO. Extraction of Phytochemical Compounds of Leea guineensis (G. Don) Leaves Using Non-polar and Polar Solvents. Eur J Med Plants. 2020; 27:24-31.

Gómez-Mejía E, Rosales-Conrado N, León-González ME, Madrid Y. Citrus peels waste as a source of value-added compounds: Extraction and quantification of bioactive polyphenols. Food Chem. 2019; 295:289-299.

Brown JD and Winterstein AG. Potential adverse drug events and drug–drug interactions with medical and consumer cannabidiol (CBD) use. J Clin Med. 2019; 8(7):989.

Alamgir AN. Cultivation of herbal drugs, biotechnology, and In Vitro production of secondary metabolites, highvalue medicinal plants, herbal wealth, and herbal trade. In Therapeutic Use of Medicinal Plants and Their Extracts. Springer Cham. 2017; 1:379-452.

Bilal M and Iqbal HM. Biologically active macromolecules: Extraction strategies, therapeutic potential and biomedical perspective. Int J Biol Macromol. 2020; 151:1-8.

Dobolyi A, Oláh S, Keller D, Kumari R, Fazekas EA, Csikós V, Renner É, Cservenák M. Secretion and function of pituitary prolactin in evolutionary perspective. Front Neurosci. 2020; 14:621.

Furtado D, Björnmalm M, Ayton S, Bush AI, Kempe K, Caruso F. Overcoming the blood–brain barrier: the role of nanomaterials in treating neurological diseases. Adv Mat. 2018; 30(46):1801362.

Cheipesh TA, Kharchenko DV, Taranets YV, Rodik RV, Mchedlov-Petrossyan NO, Poberezhnyk MM, Kalchenko, VI. Reaction rates in aqueous solutions of cationic colloidal surfactants and calixarenes: Acceleration and resolution of two steps of fluorescein diesters hydrolysis. Colloids and Surfaces A: Adv Mat Res. 2020; 606:125479.

Ursino M, Véronneau-Veilleux F, Nekka F. A non-linear deterministic model of action selection in the basal ganglia to simulate motor fluctuations in Parkinson's disease. Chaos: An Inter J Nonlinear Sci. 2020; 30(8):083139.

Oyagbemi AA, Omobowaleb TO, Adejumobi OA, Owolabi AM, Ogunpolu BS, Falayi OO, Hassan FO, Ogunmiluyi IO, Senuga ER, Ola-Davies OE, Soetan KO. Antihypertensive power of Naringenin is mediated via attenuation of mineralocorticoid receptor (MCR)/angiotensin converting

enzyme (ACE)/kidney injury molecule (Kim-1) signaling pathway. Eur J Pharmacol. 2020; 16:173142.

Ashwini B. Pseudocholinesterase levels as a prognostic marker in organophosphorous compound poisoning. J Assoc Physicians India, 2020; 68(1):e104

Mascarenhas AM, de Almeida RB, de Araujo Neto MF, Mendes GO, da Cruz JN, Dos Santos CB, Botura MB, Leite FH. Pharmacophore-based virtual screening and molecular docking to identify promising dual inhibitors of human acetylcholinesterase and butyrylcholinesterase. J Biomol Struct Dyn. 2020; 23:1-10.

Prasad SB, Mysore S, Raj CA, Rangappa KS, Mahadevaiah K, Kumar CS. Synthesis of Novel 2, 3-Dihydro-5, 6- dimethoxy-2-((piperidin-4-yl) methyl) inden-1-one Derivatives as Acetyl Cholinesterase Inhibitors. Curr Bioact Comp. 2020; 16(3):348-357.