Artemisia judaica Attenuates Hyperglycaemia-Mediated Oxidative Stress and Cardiac Injury in Streptozotocin-Induced Diabetic Rats
doi.org/10.26538/tjnpr/v4i10.11
Keywords:
Cardiac injury, Antioxidants, Diabetes, Oxidative stress, Artemisia judaicaAbstract
Hyperglycemia-induced oxidative stress is a recognized risk factor for cardiovascular diseases and heart failure. The study investigated the cardioprotective effect of Artemisia judaica (A. judaica) on diabetes-induced oxidative injury in rats. A rat model of diabetes was achieved by intraperitoneal (i.p.) injection of streptozotocin (55 mg/kg). After confirmation of diabetes, rats were treated with A. judaica (300 mg kg−1 day−1, p.o.) daily for six weeks. Diabetic rats demonstrated a significant increase in fasting blood glucose and glycosylated hemoglobin (HbA1c) and decrease in insulin levels. Hyperglycaemia-induced cardiac injury was characterised by increased levels of creatine kinase-MB (CK-MB), lactate dehydrogenase (LDH) and aspartate aminotransferase (AST) activities in the plasma, along with several histological alterations in the myocardium. The hearts of diabetic rats showed increased levels of malondialdehyde (MDA), with a significant decrease in the content of glutathione (GSH) and the activities of superoxide dismutase (SOD) and catalase (CAT). The oral A. judaica treatment ameliorated hyperglycaemia, prevented hyperglycaemia-induced cardiac injury, boosted antioxidants and suppressed oxidative stress. These findings showed that A. judaica protected against diabetes-induced cardiac injury through attenuation of oxidative stress. However, the exact mechanism underlying the cardioprotective effects of A. judaica undoubtedly deserves further exploration in future studies.
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