Evaluation of antiulcer activity of the aerial parts of Caralluma dalzielii N. E. Brown in Wistar rats

Chinenye J. Ugwah-Oguejiofor1*, Firdausi S. Inuwa1, Kabiru Abubakar1, Oguejiofor M. Ugwah2, Emmanuel H. Mshelia3, Mohammed Umar4
1Department of Pharmacology & Toxicology, Faculty of Pharmaceutical sciences, Usmanu Danfodiyo University, Sokoto, Nigeria.
2Department of Pharmacy, Usmanu Danfodiyo University Teaching Hospital, Sokoto, Nigeria.
3Department of Pharmacognosy and Ethnopharmacy, Faculty of Pharmaceutical sciences, Usmanu Danfodiyo University, Sokoto, Nigeria.
4Department of Pathology, Usmanu Danfodiyo University Teaching hospital, Sokoto, Nigeria.
Corresponding Author: [email protected]; Tel: +234 80 36098241
Recieved Date: August 24, 2017; Accepted Date: September 27, 2017; Published Date: 05 October 2017
Citation: Ugwah-Oguejiofor CJ, Inuwa FS, Abubakar K, Ugwah OM, Mshelia EH, Umar M. Evaluation of antiulcer activity of the aerial parts of Caralluma dalzielii N. E. Brown in Wistar rats. Tropical Journal of Natural Product Research 2017; 1(4):168-172. doi.org/10.26538/tjnpr/v1i4.6 https://doi.org//10.26538/tjnpr/v1i4.6
Copyright: © 2017 Ugwah-Oguejiofor et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
ABSTRACT

The aerial part of Caralluma dalzielii has been used by traditional healers in the North-west Nigeria for the treatment of stomach related problems including pain in the epigastrium. The study evaluated the antiulcer activity of aqueous extract of the aerial parts of Caralluma dalzielii (AECD) in Wistar rats. Phytochemical analysis of AECD was determined. The antiulcer activity of AECD (100, 200 and 400 mg/kg) was evaluated in absolute ethanol and indomethacin-induced ulcer models in Wistar rats following established methods. In the two models, ulcer indices and percentage gastroprotection were determined. Histopathological examination of the excised rats’ stomachs was carried out. The result of the phytochemical analysis of AECD showed the presence of flavonoids, tannins, saponins, sterols, and glycosides. AECD caused a significant (p <0.05-0.001) decrease in mean ulcer indices in absolute ethanol (83.4-100%) and indomethacin-induced (31.6-81.6%) ulcer models compared with the control. The decrease in the ulceration in the two models were dose-dependent. Histological assessment of the stomachs showed an increase in repair of the mucosal membrane as the dose of AECD increased. There was a complete repair of the mucosal membrane at 400 mg/kg in the absolute ethanol-induced model. In conclusion, the results suggest that AECD has antiulcer effect in the absolute ethanol and indomethacin-induced ulcer models and this may be due to the presence of some bioactive compounds.

Keywords: Caralluma dalzielii, Ethanol-induced, Indomethacin-induced, Antiulcer, Gastroprotection
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