Sesquiterpenoids from Illicium difengpi and their Chemotaxonomic Significance

Chun-tong Li1,2, Cui Tong2, Xiang Li1, Zhi-jun Wu2, Wan-sheng Chen2*
1Department of Pharmacy and Pharmacology, First Affiliated Hospital of PLA General Hospital, Beijing, 100048, P.R. China
2Department of Pharmacy, Shanghai Changzheng Hospital, Second Military Medical University, Fengyang Road 415, Shanghai 200003, P.R. China
Corresponding Author: [email protected]; [email protected]; Tel: +86 021 81886181
Recieved Date: August 30, 2017; Accepted Date: September 15, 2017; Published Date: 05 October 2017
Citation: Li C, Tong C, Li X, Wu Z, Chen W. Sesquiterpenoids from Illicium difengpi and their Chemotaxonomic Significance. Tropical Journal of Natural Product Research 2017; 1(4):158-162. doi.org/10.26538/tjnpr/v1i4.4 https://doi.org/10.26538/tjnpr/v1i4.4
Copyright: © 2017 Li et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
ABSTRACT

Illicium difengpi (family Illiciaceae) is a known medicinal plant used in Ancient Chinese medicines for the treatment of diseases and infections. The purpose of the present study was to investigate the chemical constituents of the stem bark of Illicium difengpi and determine their chemotaxonomic significance. The stem barks of I. difengpi were purchased from Caitongde Pharmacy and authenticated by Professor Lian-na Sun. The 80 % ethanol extract was fractionated with silica gel column chromatography (C.C.) and compounds were isolated with ODS C.C., silica gel (SiO2) C.C. and preparative/semipreparative HPLC from the fractions. The chemical structures were elucidated by NMR spectroscopy and mass spectrometry, as well as the comparison of spectra data with that reported in the literature. The present phytochemical investigation on Illicium difengpi led to the isolation and characterization of 13 sesquiterpenoids, including five eudesmanes, three cadinanes, two bullatanes and three other types of sesquiterpenoids. All compounds except compound 2 were isolated from this species for the first time. In addition, compounds 1, 3, 4, 5, 7, 8, 11 and 13 have not been reported in any species of the genus Illicium and the family Illiciaceae. Sesquiterpenoid compounds from I. difengpi may have the potential to produce new insights into the historical debate concerning the systematic position and phylogenetic relationship of the genus Illicium.

Keywords: Illicium difengpi, Sesquiterpenoid, Chemotaxomic, Illiciaceae
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