Bioassay-coupled Chromatographic Analysis of Medicinal Natural Products: A Review

Taiwo O. Elufioye
Department of Pharmacognosy, Faculty of Pharmacy, University of Ibadan, Nigeria
Corresponding Author: [email protected]; Tel: +234-8033850773
Recieved Date: July 11, 2017; Accepted Date: September 05, 2017; Published Date: 09 September 2017
Citation: Elufioye TO. Bioassay-coupled Chromatographic Analysis of Medicinal Natural Products: A Review. Tropical Journal of Natural Product Research 2017; 1(3):100-104. https://doi.org/10.26538/tjnpr/v1i3.3
Copyright: © 2017 Elufioye. This is an open-access article distributed under the terms of the Creative Commons Attribution License,, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
ABSTRACT

Medicinal plants have found immense use in drug discovery over the years as several chemically available drugs today are either directly from plant secondary metabolites or have their templates from such. Recent advances in the application of bioassay-coupled chromatographic analysis of plant extracts have led to reliable characterization of unknown samples with regards to their activity profile as well as the compounds responsible for observed activity. This paper reviews the progress made in the field of bioassay-chromatography hyphenated techniques for natural products analysis, notably medicinal plants. Different bioassays including microbial, biochemical, micro-chemical and cell based assays as well as several chromatographic and spectroscopic techniques such as Thin Layer Chromatography (TLC), High Performance Thin Layer Chromatography (HPTLC), Liquid Chromatography (LC), Over-Pressured Layer Chromatography (OPLC), Gas Chromatography (GC), Nuclear Magnetic Resonance (NMR), Fourier Transform Infra-red (FTIR) spectroscopy, Mass Spectrometry (MS), Surface Enhanced Raman Spectroscopy (SERS), Diffuse Reflectance Infrared Fourier Transform (DRIFT), etc. are discussed in this paper.

Keywords: Medicinal plants, Bioassay, Chromatographic analysis, Hyphenated techniques, Secondary metabolites.
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