Gastro-Floating Drug Delivery Systems - A Review

Ovenseri C. Airemwen* and Michael U. Uhumwangho
Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, University of Benin, Nigeria.
Corresponding Author: [email protected]; Tel: +234-8133737933
Recieved Date: July 05, 2017; Accepted Date: September 03, 2017; Published Date: 09 September 2017
Citation: Airemwen CO, Uhumwangho MU. Gastro-Floating Drug Delivery Systems - A Review. Tropical Journal of Natural Product Research 2017; 1(3):105-109. https://doi.org/10.26538/tjnpr/v1i3.4
Copyright: © 2017 Airemwen and Uhumwangho. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
ABSTRACT

Sustained release and site targeted drug delivery system have been an interesting research topic in pharmaceutical sector to maximize therapeutic benefits and patient adherence to therapy. Gastro-Floating Drug Delivery System (GFDDS) is one of the numerous mechanisms to prolong gastric residence time, thereby achieving site-targeted drug release in the stomach for local or systemic effects. This method is useful for medications with narrow absorption window in the upper part of gastro intestinal tract (GIT). Several approaches to GFFDS, including effervescent and non-effervescent methods including the sublimation and sintering techniques used in the formulation of GFDDS with no floating lag time have been discussed in this review. This update also gives an overview of advantages, disadvantages and commercial products of GFDDS.

Keywords: Floating lag time, Gastric retention, Sintering, Effervescent, Non-Effervescent
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