Investigation of Polyisoprenyl Benzophenone for Anti-ulcer Potentials in Ethanol-HCl-Induced Gastric Ulcerations in Albino Rats

Edwin A. Uwagie-Ero1, Chinaka O. Nwaehujor2, Julius O. Ode3
1Department of Surgery, Faculty of Veterinary Medicine, University of Benin, Benin City, Nigeria.
2Department of Biochemistry, Faculty of Basic Medical Sciences, University of Calabar, P.M.B. 1115, Calabar, Nigeria.
3Department of Veterinary Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Abuja, P.M.B. 117 Abuja, Nigeria.

Corresponding Author: [email protected]; Tel: +2348033977590
Recieved Date: May 16, 2020; Accepted Date: June 26, 2020; Published Date: 02 July 2020
Citation: Uwagie-Ero EA, Nwaehujor CO, Ode JO. Investigation of Polyisoprenyl Benzophenone for Antiulcer Potentials in Ethanol-HCl-Induced Gastric Ulcerations in Albino Rats.  Trop J Nat Prod Res. 2020; 4(6):228-232. https://doi.org/10.26538/tjnpr/v4i6.3
Copyright: © 2020 Uwagie-Ero et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
ABSTRACT

Acute upper gastrointestinal bleeding resulting from peptic ulcers are increasingly a common medical emergency worldwide. Endoscopic treatment and acid suppression with proton-pump inhibitors are major milestones in the management of the disease, even though these treatments options have shown promising results; therapeutic management of gastric ulcer remains a challenge. In a quest to further new drug discovery, this study was carried out to evaluate the effect of polyisoprenyl bezophenone (kolanone), an isolate from the seeds of Garcinia kola on ethanol-induced gastric ulcer the effect was compared against a known anti-ulcer drug omeprazole. 
Kolanone was isolated from dried seeds of Garcinia kola via a series of chromatographic separations techniques involving the use of analytical solvents in different ratio combinations. Animals were fasted for 18 h before treatment with different doses of Kolanone (25, 50 and 75 mg /kg) or omeprazole (20 mg/kg). Gastric ulcer was induced by oral administration of ethanol-acid (25 mL/kg of 0.3 M HCl in 60% ethanol). One hour later, animals were humanely euthanized and gastric mucus was analyzed for antioxidants.
Kolanone showed a significant gastro-protective effect against ethanol-induced stomach ulcers at 50 and 75 mg/kg compared to omeprazole (20 mg/kg) and distilled water-treated rats. It also prevented the activation of lipid peroxidation induced by ethanol presumably by enhancing antioxidant enzymes (catalase, superoxide dismutase, glutathione peroxidase) potential and lowering lipid peroxidation (TBARS production) of the gastric mucosa thereby lowering mucosal injury. This effect may find beneficial applications in the therapy for ulcer patients and in wound healing.

Keywords: Polyisoprenyl bezophenone (kolanone), Gastric ulcer, Omeprazole, Oxidative stress.
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