Pharmaceutical Stability of Brands of Paracetamol Tablets under Different Environmental Conditions

Olutayo A. Adeleye1*, John O. Ayorinde2, Lateef G. Bakre1,  Oluwayemisi A. Bamiro1
1Department of Pharmaceutics and Pharmaceutical Technology, Olabisi Onabanjo University, Ago Iwoye, Ogun State, Nigeria.
2Department of Pharmaceutics and Industrial Pharmacy, University of Ibadan, Ibadan, Oyo State, Nigeria.
Corresponding Author: [email protected]; Tel: +2348033784449
Recieved Date: March 15, 2019; Accepted Date: May 27, 2019; Published Date: 09 June 2019
Citation: Adeleye OA, Ayorinde JO, Bakre LG, Bamiro OA. Pharmaceutical Stability of Brands of Paracetamol Tablets Under Different Environmental Conditions. Trop J Nat Prod Res. 2019; 3(5):149-154. https://doi.org/10.26538/tjnpr/v3i5.1
Copyright: © 2019 Adeleye et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
ABSTRACT

Drugs are exposed to some conditions which are inevitable in the shelf-life of those drugs. Such conditions are met during drug distribution to the point of consumption. If stability of a drug product is not maintained throughout its shelf-life, quality, safety, potency and efficacy will be compromised. This study aimed to investigate the effect of these conditions on the pharmaceutical stability of paracetamol tablet formulations. Three brands of paracetamol tablets were stored in their original packages under different environmental conditions (living room, kitchen, out-door and trunk of a car) for 24 months. Samples were withdrawn at different time intervals and evaluated for variations in weight, diameter, hardness, friability, content uniformity and disintegration and dissolution. One-way ANOVA and student t-test were used to compare difference in data. Organoleptic properties of the tablets were maintained for the 24 months except the brands kept out-door which had an off white colouration. Drug degradation was minimal with the paracetamol packaged in PVC blisters. The pharmaceutical stability of the three products in the living room and in the kitchen at 24 months was not adversely affected while those kept out-door and in the trunk of a saloon car was adversely affected.

Keywords: Stability, environmental conditions, degradation, drug content, paracetamol.
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