Involvement of Anti-Inflammatory Mechanism in the Antidepressant Activity of Methanol Stem Bark Extract of Adansonia digitata L. (Malvaceae)

Aishatu Shehu*, Sagir Mustapha,Isah A.Mansir, Mohammed G. Magaji
Department of Pharmacology and Therapeutics, Ahmadu Bello University, Nigeria
Corresponding Author: [email protected]; Tel: +234-803-6028298
Recieved Date: February 12, 2019; Accepted Date: February 25, 2019; Published Date: 01 March 2019
Citation: Shehu A, Mustapha S, Mansir IA, Magaji MG. Involvement of Anti-Inflammatory Mechanism in the Antidepressant Activity of Methanol Stem Bark Extract of  Adansonia digitata L. (Malvaceae).  Trop J Nat Prod Res. 2019; 3(2):54-57. https://doi.org//10.26538/tjnpr/v3i2.6
Copyright: © 2019 Shehu et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
ABSTRACT

The plant Adansonia digitata has been reported to possess antidepressant activity mediated via monoaminergic, neuroendocrine and neurotrophic pathways. This study investigated the involvement of anti-inflammatory mechanism in the antidepressant activity of methanol stem bark extract of A. digitata. Acute oral median lethal dose (LD50) was estimated using Organization for Economic Co-operation and Development (OECD 425) method. Depression was induced using Bacillus Calmette-Guerin (BCG, 0.2 mg/kg, i.p.) in mice and readings taken at 0, 4, 24 and 48 hours post BCG administration. Subsequently the antidepressant activity of the extract (250-1000 mg/kg) was assessed using tail suspension test (TST) and open field test (OFT). The extract significantly (p?0.05) decreased the rectal temperature of mice following BCG-induced sickness 4 and 48 hours post induction. The extract also significantly (p?0.05) decreased the duration of immobility in the TST at 4 and 48 hours post BCG administration. The extract significantly (p?0.05) increased the total number of line crossedby mice at 4, 24 and 48 hours post BCG administration. The ability of the extract to ameliorate BCG-induced depression suggests the possible involvement of anti-inflammatory mechanismin its antidepressant activity.

Keywords: Depression, Adansonia digitata, Bacillus Calmette-Guerin, Inflammatory mechanism
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