Synthesis, Characterization and Antimicrobial Evaluation of Co(II), Ni(II) and Cu(II) Schiff base complexes of (Z)-4-(1-pyridin-4-ylimino)propyl)phenol

Samuel A. Agbese*, Gideon A. Shallangwa, Sulaiman O. Idris
Department of Chemistry, Ahmadu Bello University Zaria, Nigeria
Corresponding Author: [email protected]; Tel: +234 8065285820
Recieved Date: August 15, 2018; Accepted Date: August 30, 2018; Published Date: 21 September 2018
Citation: Agbese SA, Shallangwa GA, Idris SO. Synthesis, Characterization and Antimicrobial Evaluation of Co (II), Ni (II) and Cu (II) Schiff base complexes of (Z)-4-(1-pyridin-4-ylimino)propyl)phenol. Trop J Nat Prod Res. 2018; 2(9):429-432.
Copyright: © 2018 Agbese et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

The demand for discovery and development of new antimicrobial agents has continued to increase due to the emergence and increasing prevalence of drug resistant pathogens. The study evaluated the synthesis, characterization and antimicrobial activity of Co(II), Ni(II) and Cu(II) Schiff base complexes derived from condensation of (Z)-4-(1-pyridin-4-ylimino) propyl) phenol with their respective metal chlorides. The synthesized Co(II), Ni(II) and Cu(II) Schiff base complexes were characterized by UV-Visible analysis, FTIR, Molar conductivity measurement and Magnetic susceptibility test. The results of the FTIR suggest that the metal complexes possess coordinated water molecules and the absorption band with wavenumber 1651.12 and 1658.84 cm-1 shows that the nitrogen of the imine bond participated in the coordination to the metal center. The magnetic susceptibility measurements show magnetic moments of 4.68 BM, 3.10 BM and 1.95 BM corresponding to Co (II), Ni (II) and Cu (II) complexes, respectively, thus, indicating the metal complexes possess octahedral geometry. The molar conductivity tests show values of 82.90 ?-1mol-1cm2, 62.60 ?-1mol-1cm2 and 50.80 ?-1mol-1cm2 which corresponds to Co(II), Ni(II) and Cu(II) complexes respectively. The molar conductivity values for the complexes show that they do not readily dissociate in solution and are non-electrolytic in nature. The metal to ligand ratio for each of the metal complexes is 1:2. The metal complexes were evaluated for their antimicrobial activity against two gram positive bacteria, two gram negative bacteria and two fungi organisms. The synthesized metal complexes show significant activities against most of the test organisms.

Keywords: Schiff base, FTIR, UV-Visible, metal complexes, antimicrobial.
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