Extract of the Leaves of Hydrolea glabra Schum. &Thonn. (Hydrophyllaceae), Exerts Anxiolytic Effect on Swiss Albino Mice

Chikaodinaka A. Anyanwu-Ndulewe1, Aderonke A. Adepoju-Bello1, Samuel Fageyinbo2, HerbertCoker1
1Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Lagos
2Department of Pharmacology, Toxicology and Therapeutics, Faculty of Basic Medical Sciences, University of Lagos.

Corresponding Author: [email protected]; Tel: +2348037152220
Recieved Date: June 04, 2018; Accepted Date: September 04, 2018; Published Date: 21 September 2018
Citation: Anyanwu-Ndulewe CA, Adepoju-Bello AA, Fageyinbo S, Coker H. Extract of the Leaves of Hydrolea glabra Schum. & Thonn. (Hydrophyllaceae), Exerts Anxiolytic Effect on Swiss Albino Mice. Trop J Nat Prod Res. 2018; 2(9):413-417.  https://doi.org//10.26538/tjnpr/v2i9.1
Copyright: © 2018 Anyanwu-Ndulewe et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

The plant,Hydrolea glabra, is used in neurodegenerative disorders associated with dementia, where personality changes present as symptoms such as anxiety, depression and sleep changes. This notwithstanding, no pharmacological studies have been carried out on the anxiolytic and sedative properties of the plant. This research evaluated the anxiolytic effects of the extract of the plant, Hydrolea glabra, in order to validate the folkloric claims of its usefulness in the management of dementia. Methanol extract of the leaves of Hydrolea glabra was analysed for the phytochemical composition and the anxiolytic effect was evaluated, using the Elevated plus maze, Hole board and Phenobarbitone-induced sleeping time models in mice. Phytochemical screening showed the presence of alkaloids, terpenoids, saponins, phenolics, condensed tannins, cardiac glycosides and reducing sugars. There was significant percentage increase (48%) in the time spent in the open arms, by the rats given the extracts, which was comparable to 42% of the standard Diazepam (1 mg/kg b.w) in the elevated plus maze model. The extract at 200mg/kg, also had a sedative effect by prolonging the phenobarbitone-induced sleeping time by 45% when compared to the standard, Diazepam. The anxiolytic effect observed may substantiate the medicinal relevance of the plant, by providing the pharmacological basis for the use of this plant in folkloric medicine practice.

Keywords: Anxiolytic activity, Hydrolea glabra, exploratory behaviour, sedative activity, dementia.
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