Bio-Modulation of Platelet Count Following the Administration of Tender Coconut Water in New Zealand Male Rabbits

Ese Onuyoh-Adaitire1*, Blessing Onuyoh2, Eloghosa E. Ogbonmwan1, Eshiagiamhe G. Tafamel1
1Department of Physiology, School of Basic Medical Sciences, University of Benin, Benin City, Nigeria.
2Department of Medical Laboratory Science, School of Basic Medical Sciences, University of Benin, Benin City, Nigeria.

Corresponding Author: [email protected]; Tel: +234 8033904535
Recieved Date: June 28, 2017; Accepted Date: July 22, 2018; Published Date: 10 August 2018
Citation: Onuyoh-Adaitire E, Onuyoh B, Ogbonmwan EE, Tafamel EG. Bio-Modulation of Platelet Count Following the Administration of Tender Coconut Water on New Zealand Male Rabbits.  Trop J Nat Prod Res. 2018; 2(8):409-412.
Copyright: © 2018 Onuyoh-Adaitire et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Coconut is a fruit of great health benefits. This study was aimed at investigating the bio-modulatory effect that oral ingestion of tender coconut water (TCW) exerts on the body during acute inflammatory processes in New Zealand male rabbits. A longitudinal study was adopted in this study using fifteen rabbits (n = 15) and having 4 treatments comprising them. Treatment 1 served as the basal stage without TCW administration. Treatment 2 includes 2 weeks post coconut water administration. Treatment 3 includes 4 weeks post TCW administration. Treatment 4 includes withdrawal of TCW administration. Oral doses of TCW, 5 mL/kg body weight were administered daily and maintained for six weeks. Blood samples were collected at weeks 2, 4 and 6 for the estimation of haematological parameters including white blood cell counts (WBC) and differentials, erythrocyte sedimentation rate (ESR), platelet counts and C-reactive protein concentration. Monocyte concentration (11.07 ±1.19%) in treatment 2 was significantly (p < 0.05) higher than those of treatment 1, 3 and 4%. Platelet concentration in group 1 was increased significantly (p < 0.05) compared to treatments 2 and 3 following the administration of TCW and increased again upon withdrawal of TCW [treatment 4 (280.27 ± 25.30 x 109/L)]. C-reactive protein was increased significantly in treatment 1 (2.93 ± 0.42) compared to treatments 2, 3 and 4. The data obtained from this study showed that the physiology of platelet during acute inflammatory conditions may be modulated by the administration of TCW.

Keywords: Tender Coconut water (TCW), Rabbits, Platelets, haematological parameters.
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ISSN: 2616-0684 (Print)
ISSN: 2616-0692 (Online)
DOI: 10.26538/tjnpr
ISI Impact Factor: 0.562
Index Copernicus Value (ICV) for 2017: 59.83

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