GC-MS and Heavy Metal Analysis of Gasca D Herbal Formulation

Ibrahim S. Ismail1*, Ibrahim D. Gezawa2,3, Muhammed F. Yahya3, Bashir Chedi4, Kabir Nafisatu1, Imam A. Abdulkadir5
1Department of Biochemistry, Federal University Dutse, Jigqwq stqte, Nigeria.
2Department of Medicine, Aminu Kano Teaching hospital, Kano, Nigeria.
3Department of Medicine, Abdullahi Wase Specialist Hospital, Kano, Nigeria.
4Department of Pharmacology, Bayero University Kano, Nigeria.
5Department of Biochemistry, Bayero University Kano, Nigeria.

Corresponding Author: [email protected]; Tel: +2348036316108
Recieved Date: July 14, 2018; Accepted Date: August 10, 2018; Published Date: 10 August 2018
Citation: Ismail IS, Gezawa ID, Yahya MF, Chedi B, Nafisatu K, Abdulkadir IA. GC-MS and Heavy Metal Analysis of Gasca D Herbal Formulation. Trop J Nat Prod Res. 2018; 2(8):396-400.  https://doi.org//10.26538/tjnpr/v2i8.5
Copyright: © 2018 Ismail et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Gasca D herbal formulation is an antidiabetic medicine produced exclusively from natural ingredients. The aim of this study was to evaluate the levels of essential and toxic heavy metals as well as to identify bioactive compounds present in Gasca D herbal formulation. The level of some essential elements (Copper, chromium, Cobalt, Iron, Manganese, Nickel and zinc) and toxic (Cadmium, Arsenic, Vanadium, Mercury, and Lead) heavy metals were determined using microwave plasma-atomic emission spectrometry (MP-AES). The result shows no traces of Lead, Mercury, Arsenic and Zinc. Iron was found to have highest concentration 67.16 + 7.5 µg/g and Cadmium lowest concentration 0.4 + 0.03µg/g. Vanadium, the derivatives of which have been reported to have insulin-mimetic and antidiabetic properties was found at a concentration of 2.6 µg/g. The Gas Chromatography-Mass Spectrometric (GC-MS) analysis of Gasca D herbal formulation revealed the presence of 16 compounds which include N-Formyl-beta-alanine, Paromomycin, 3,4-Altrosan, Benzamide, 1,3,4-Thiadiazol-2-amine, Carbamodithioic acid, Carbonic acid, alpha-D-Glucopyranoside, Ethyl isocyanide, 2-Propanesulfinic acid, Propanamide, 2-Butenenitrile, Dicyclopropyl carbinol, Isoxazolidine, 1,5-Hexadiene, 10-Azido-1-decanethiol. The result indicates that the mean levels of toxic metals in Gasca D herbal formulation were below WHO permissible levels. Gasca D herbal formulation contains various bioactive compounds which may serve various medicinal applications.

Keywords: GC-MS, Heavy Metals, Toxicity, antidiabetic.
Back to Articles