Analgesic and anti-inflammatory studies of methanol stem bark extract of Burkea africana Hook (Fabaceae)

Aisha O. Musa1*, Habatullah K. Usman1, Irisim Titus1, Amina B. Olorukooba2, Abubakar B. Aliyu3, Hadiza Bello1
1Department of Botany, Ahmadu Bello University, Zaria, Nigeria.
2Department of Pharmacology and Therapeutic, Ahmadu Bello University, Zaria, Nigeria.
3Department of Chemistry, Ahmadu Bello University, Zaria, Nigeria.

Corresponding Author: [email protected]; Tel: +2347038086164
Recieved Date: June 21, 2018; Accepted Date: July 31, 2018; Published Date: 10 August 2018
Citation: Musa AO, Usman HK, Titus I, Olorukooba AB, Aliyu AB, Bello H. Analgesic and anti-inflammatory studies of methanol stem bark extract of Burkea africana Hook (Fabaceae).Trop J Nat Prod Res. 2018; 2(8):375-379.  https://doi.org//10.26538/tjnpr/v2i8.1
Copyright: © 2018 Musa et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
ABSTRACT

Burkea africana Hook (Fabaceae) is a plant used in traditional medicine for the treatment of pain and inflammation in Africa. The methanol stem bark extract was evaluated for analgesic property using acetic acid induced writhing and hot plate test in mice while the anti-inflammatory property was evaluated using carrageenan- induced paw oedema. Acute toxicity studies and phytochemical screening using standard protocol was also conducted. Preliminary phytochemical screening of the extract revealed the presence of flavonoids, tannins, steroids and triterpenes, cardiac glycosides and saponins. The intraperitoneal median lethal dose (LD50) in mice was found to be 471.17 mg/kg body weight. The extract at all tested doses (20, 40 and 80 mg/kg) significantly (P? 0.001) decreased abdominal contractions induced by acetic acid and also significantly (P? 0.01) delayed the mean reaction time of the mice. The extract at all doses showed no significant anti-inflammatory activity. The results obtained from this study showed that the methanol stem bark extract of Burkea africana possesses both central and peripheral analgesic activities. This provides a rationale for its traditional use against pain.

Keywords: Burkea africana, analgesic, anti-inflammatory, carrageenan.
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ISSN: 2616-0684 (Print)
ISSN: 2616-0692 (Online)
DOI: 10.26538/tjnpr
ISI Impact Factor: 0.562
Index Copernicus Value (ICV) for 2017: 59.83

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