Inhibitors of Sporangia Formation of Phytophthora capsici from Polygonum capitatum

Umer Farooq1, LiHong Cheng1, Hui Zhang1, Qian Wang1, YuanChao Wang2, Hirokazu Kawagishi3, JianHua Qi1*
1College of Pharmaceutical Sciences, Zhejiang University, Yu Hang Tang Road 866, Hangzhou 310058, China.
2College of Plant Protection, Nanjing Agricultural University, Nanjing 210095, China.
3Research Institute of Green Science and Technology, Shizuoka University, 836 Ohya, Surugaku, Shizuoka 422-8529, Japan.

Corresponding Author: [email protected] ; Tel: +86-571-88208627
Recieved Date: June 21, 2018; Accepted Date: July 05, 2018; Published Date: 08 July 2018
Citation: Farooq U, Cheng L, Zhang H, Wang Q, Wang Y, Kawagishi H, Qi J. Inhibitors of Sporangia Formation of Phytophthora capsici from Polygonum capitatum. Trop J Nat Prod Res. 2018; 2(7):358-361.
Copyright: © 2018 Farooq et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

The genus Phytophthora comprises of nearly 120 pathogenic species which causes both economic and enviormental damage. This study aims to isolate active compounds from natural products for inhibition of sporangia formation of Phytophthora capsici. The ethyl acetate (EtOAc) layer of the methanol (MeOH) extract of Polygonum capitatum exhibited significant activity. The ethyl acetate (EtOAc) fraction was then subjected to bioassay-guided separation and purification to afford five active flavonoids which significantly inhibited sporangia formation on Phytophthora capsici. The structures were elucidated by spectroscopic analysis and comparison of spectroscopic data with those reported. The active compounds were identified as myricetin 7-O-?-L-rhamnopyranoside (1), quercetin 3-O-?-D-glucopyranoside (2), quercetin 4?-O-?-L-rhamnopyranoside (3), quercetin 3-O-(2??-galloyl)-?-L-rhamnopyranoside (4), and kaempferol 3-O-?-L-rhamnopyranoside (5). Compounds 1, 2, and 3 were isolated from P. capitatum for the first time. Moreover, the stereo structure of sugar moiety of 3 was corrected by chemical derivatization means. Compounds (1-5) isolated from P. capitatum significantly inhibited sporangia formation of Phytophthora capsici.

Keywords: Flavonoids, Inhibitors, Phytophthora capsici, Polygonum capitatum, Sporangia formation.
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ISSN: 2616-0684 (Print)
ISSN: 2616-0692 (Online)
DOI: 10.26538/tjnpr
Index Copernicus Value (ICV) for 2017: 59.83

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