Antioxidant Potential of Phoenix dactylifera Linn Extract and its Effects on Calcium Channel Antagonist in the Treatment of Withdrawal Syndrome in Morphine Dependent Rats

Ibrahim H. Sani1*, Ibrahim Sulaiman2, Iliyasu Zubairu3, Umar S. Abdussalam4, Mohd K.R. Adzim5
1Department of Human Physiology, Faculty of Basic Medical Sciences, Yusuf Maitama Sule University, Kano, Nigeria.
2Department of Human Physiology, Faculty of Basic Medical Sciences, Bayero University, Kano, Nigeria.
3Department of Community Medicine, Bayero University, Kano, Nigeria.
4Department of Pharmacology and Therapeutics, Faculty of Pharmaceutical Sciences, Bayero University, Kano, Nigeria.
5Faculty of Health Sciences, Universiti Sultan Zainal Abidin, Malaysia.

Corresponding Author: [email protected]; Tel: +2348036858682
Recieved Date: February 22, 2018; Accepted Date: July 06, 2018; Published Date: 08 July 2018
Citation: Sani IH, Sulaiman I, Zubairu I, Abdussalam US, Adzim MKR. Antioxidant Potential of Phoenix dactylifera Linn Extract and its Effects on Calcium Channel Antagonist in the Treatment of Withdrawal Syndrome in Morphine Dependent Rats. Trop J Nat Prod Res. 2018; 2(7):309-313.
Copyright: © 2018 Sani et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Date fruit Phoenix dactylifera (Linn) is remarkably known for its nutritional and numerous health benefits that are linked to its wide variety of bioactive compounds. Calcium channels were reported to play an important role in the mechanism of morphine dependence and withdrawal syndrome. This study examined the antioxidant potential of date fruit extract on calcium channel antagonists in the treatment of withdrawal syndrome in morphine-dependent rats. A total of thirty six (N=36) Sprague-Dawley adult male rats (weight 200-220 g) were used in this study. Morphine dependence was induced by subcutaneous injection of an increasing dose of morphine (ascending from 10 to 60 mg/kg) twice daily over a period of 5 days. The withdrawal syndrome was precipitated by administration of naloxone (i.p) 2 hours after the last morphine injection. For chronic study, the extracts or nifedipine were administered 30 minutes prior to each morphine injection, whereas the extract or nifedipine was only administered one hour after last morphine injection in acute studies. The rats were observed for the presence of withdrawal signs (jumps, tremor, eye ptosis, teeth chattering, wet dog shaking, diarrhoea and urination). The treatments suppressed withdrawal syndrome in morphine dependent rats. A statistically significant difference was observed between chronic and acute administration of extracts and nifedipine (p<0.001). The suppression of naloxone precipitated morphine withdrawal by the extracts possibly occurred via calcium channel blockage and the reversal of neuronal adaptation by its phenolic compounds. Therefore, Phoenix dactylifera could serve as an appropriate treatment of opioid addiction.

Keywords: Antioxidant, Calcium channel antagonist, Morphine withdrawal syndrome, Phoenix dactylifera.
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ISSN: 2616-0684 (Print)
ISSN: 2616-0692 (Online)
DOI: 10.26538/tjnpr
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