Characterization and Evaluation of the Suspending Potentials of Corchorus olitorius Mucilage in Pharmaceutical Suspensions

Chukwuemeka Paul Azubuike, Mohammed Aliyu Alfa, Bukola Aminat Oseni
Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, University of Lagos, College of Medicine Campus, PMB 12003, Surulere, Lagos, Nigeria
Corresponding Author's Email: [email protected]
ABSTRACT

The study was aimed at extraction, characterization and evaluation of suspending potentials of Corchorus olitorius mucilage (COM) in comparison with acacia BP (ACG) in pharmaceutical suspensions. Corchorus olitorius mucilage was extracted from its dried leaves decoction by differential precipitation with acetone, dried and micronized into powder. The powdered mucilage was screened and subjected to physico-chemical and flow properties analyses with acacia BP powder using standard methods. Functional groups elucidation and thermal analysis of the test mucilage was done using Fourier transform infrared spectroscopy (FTIR) and differential scanning calorimetry (DSC) respectively. Paracetamol suspensions were formulated using various concentrations of COM and ACG (1.0 - 3.0 %w/v) and assessed for their sedimentation volume, redispersibility, degree of flocculation, flow rate, particle size, pH, viscosity, drug content and in-vitro release profile. Drug-excipients compatibility was also assessed. The phytochemical tests revealed the presence of mucilage and carbohydrates and absence of starch and enzymes in the dried mucilage. COM powders had lower pH, percentage moisture content and bulk and tapped densities than ACG powders. The true density, porosity, angle of repose, Carr’s index, Hausner’s ratio and microbial load of COM powders were higher than those of ACG. Formulation containing 1.5 %w/v COM had a comparable suspending property to formulation containing 2.5 %w/v ACG. Results of accelerated stability studies showed no significant change in pH, viscosity, sedimentation volume and degree of flocculation of formulated suspensions. Corchorus olitorius mucilage at the low concentration of 1.5 %w/v could be employed as a suspending agent for formulation of pharmaceutical suspensions.

Keywords: Corchorus olitorius, suspending potentials, paracetamol, physicochemical properties, suspensions
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