Protective Effect of Ethanol Extract of Senna occidentalis Leaf Against CadmiumInduced Hepatotoxicity in Rats

Adedosu Olaniyi Temitope1, Jacob Adikwu Gowon2, Alabi Zaccheaus Oluwatayo1
1Department of Biochemistry, Ladoke Akintola University of Technology, Ogbomoso, Oyo State
2Department of Applied Chemistry, Federal University, Dutsinma, Katsina state
Corresponding Author's Email: [email protected]
ABSTRACT

Cadmium is a known environmental and industrial toxicant exposure to which leads to the generation of reactive oxygen species (ROS), with attendant oxidative damage to membrane lipids, cellular proteins and DNA. Recently, the use of medicinal plants as prophylactic or therapeutic agents against certain diseases has become popular. This study was aimed at assessing the hepatoprotective effect of ethanol extract of Senna occidentalis leaf in cadmium intoxicated rats. Thirty-five rats, each weighing on the average 150 ± 40 g were randomly selected into seven groups of five rats each. Each group received appropriate treatment. At the end of the treatment period, each rat was sacrificed and the antioxidant status determined using extant methods. The data collected were expressed as mean ± SD and statically analyzed using one-way analysis of variance (ANOVA). The results showed that cadmium intoxication significantly increased liver malondialdehyde (MDA) levels but caused decrease in superoxide dismutase (SOD) and catalase (CAT) activities as well as reduced glutathione levels compared to control. The level of fragmented DNA also increased significantly. However, co-treatment of rats with cadmium chloride and the extract significantly reduced the concentrations MDA and the severity of the DNA fragmentation. Along with these are concomitant increase in SOD and CAT activities and GSH concentration. Ethanol extract of Senna occidentalis leaf possesses bioactive agents capable of protecting liver against cadmium-induced lipid peroxidative membrane damage. The hepatoprotection potential of the leaf extract is likely due to the boost in the organs antioxidant capacity.

Keywords: Hepatoprotective, Cadmium, Antioxidant, Rats, Senna occidentalis
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