Formulation and In Vitro Evaluation of Ciprofloxacin Matrix Tablets: Effect of Drug-Polymer Ratio

Lateef G. Bakre* and Temitayo O. Sholuade
Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Olabisi Onabanjo University, Ondo State, Nigeria.
Corresponding Author: [email protected]; [email protected]; Tel: +234-8033700102
Recieved Date: April 25, 2018; Accepted Date: May 09, 2018; Published Date: 10 May 2018
Citation: Bakre LG and Sholuade TO. Formulation and In Vitro Evaluation of Ciprofloxacin Matrix Tablets: Effect of Drug-Polymer Ratio. Trop J Nat Prod Res. 2018; 2(5):250-253.  https://doi.org//10.26538/tjnpr/v2i5.9
Copyright: © 2018 Bakre and Sholuade . This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
ABSTRACT

An ideal tablet should combine good mechanical strength with adequate drug release profile. This work aims to study the effect of drug-polymer ratio on the mechanical properties and release profile of ciprofloxacin tablet. Ciprofloxacin formulations containing drug and the polymers (Chrysophyllum albidum gum (CAG), hydroxypropylmethylcellulose (HPMC) and xanthan gum) in ratios of 2:1, 1:1 and 1:2, respectively were prepared by direct compression. The crushing strength, friability and the time taken for 50% (T50) and 90% (T90) drug release were obtained. The mechanism of drug release was also determined. Tablets containing CAG had significantly (p<0.05) lower crushing strength than those containing other polymers. In tablets containing xanthan gum and HPMC, there was an increase in crushing strength as the amount of polymer was increased to equal amount with the drug, but a further increase in polymer concentration to twice the amount of the drug resulted in a decrease in strength. T50 and T90 increased with increase in polymer concentration for formulations containing CAG. Drug release in formulations containing CAG and xanthan gum was by first order kinetics while the zero order model was the most prominent in tablets with HPMC. The first order constant, k1 decreased with increase in polymer concentration for tablets with CAG while the reverse was the case for xanthan gum. However, irrespective of the drug-polymer ratio, all the formulations exhibited super case transport mechanism. This study suggests that the drug-polymer ratio has a significant influence on the mechanical strength and the release profile of ciprofloxacin tablets.

Keywords: Drug-polymer ratio, Chrysophyllum albidum gum, hydroxypropylmethylcellulose, xanthan gum, Ciprofloxacin matrix tablets.
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ISSN: 2616-0684 (Print)
ISSN: 2616-0692 (Online)
DOI: 10.26538/tjnpr

ISI Impact Factor: 0.562

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